Effects of phenylalanine, histidine, and leucine on basal and GHRH-stimulated GH secretion and on PRL, insulin, and glucose levels in short children, comparison with the effects of arginine

Journal of Pediatric Endocrinology and Metabolism

Volumn 9, Issue 5, 1996, Pages 523-531

  Bellone, J ^a   Valette, M R ^a   Aimaretti, G ^a   Segni, M ^b   Volta, C ^c   Cardinale, G ^d   Baffoni, C ^a   Pasquino, A M ^b   Bernasconi, S ^c   Bartolotta, E ^d   Mucci, M ^e   Ghigo, E ^a,f  

^a UNIVERSITY OF TURIN   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF PARMA   (Italy)

^d Hospital of Recanati   (Italy)

^e Pharmacia PH   (Italy)

^f MOLINETTE HOSPITAL   (Italy)

Author keywords

Arginine; GH; Glucose; Histidine; Insulin; Leucine; Phenylalanine; PRL

Indexed keywords

ARGININE; GLUCOSE; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; HISTIDINE; INSULIN; LEUCINE; PHENYLALANINE; PROLACTIN; SERMORELIN;

ADOLESCENT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; GROWTH HORMONE RELEASE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; PRESCHOOL CHILD; SCHOOL CHILD; SHORT STATURE;

EID: 10544251059     PISSN: 0334018X     EISSN: None     Source Type: Journal    
DOI: 10.1515/JPEM.1996.9.5.523     Document Type: Article

References (25)

1. Ghigo E. Neurotransmitter control of growth hormone secretion. In: de la Cruz LF, ed. Regulation of Growth Hormone and Somatic Growth. Amsterdam: Excerpta Medica, 1992; 103-136.
2. Muller EE, Nistico G. Neurotransmitter regulation of the anterior pituitary. In: Muller EE, Nistico G, eds. Brain Messengers and the Pituitary. San Diego, CA: Academic Press, 1989; 404-537.
3. Knopf RF, Conn JW, Fajans SS, Floyd JC, Guntsche EM, Rull JA. Plasma growth hormone response to intravenous administration of amino acids. J Clin Endocrinol Metab 1965; 25: 1140-1144.
4. Kuhara T, Ikeda S, Ohneda A, Sasaki Y. Effects of intravenous infusion of 17 amino acids on the secretion of GH, glucagon, and insulin in sheep. Am J Physiol 1991; 260: E21-E26.
5. Merrimee TJ, Rabinowitz D, Fineberg SE. Arginine-initiated release of human growth hormone. N Engl J Med 1969; 26: 1434-1439.
6. Bratusch-Marrain P, Waldhausl W. The influence of amino acids and somatostatin on prolactin and growth hormone release in man. Acta Endocrinol (Copenh) 1979; 90: 403-408.
7. Parker ML, Hammonds JM, Daughaday WH. The arginine provocative test: an aid in the diagnosis of hyposomatotropism. J Clin Endocrinol Metab 1967; 27: 1129-1136.
8. Frasier SD. A review of growth hormone stimulation tests in children. Pediatrics 1978; 53: 929-937.
9. Daughaday W. The anterior pituitary. In. Wilson JD, Forster DW, eds. Williams Testbook of Endocrinology. Philadelphia, PA: Saunders, 1985: 568-613.
10. Ghigo E, Bellone J, Mazza E, Imperiale E, Procopio M, Valente F, Lala R, De Sanctis C, Camann F. Arginine potentiates the GHRH- but not the pyridostigmine-induced GH secretion in normal short children. Further evidence for a somatostatin suppressing effect of arginine. Clin Endocrinol (Oxf) 1990; 32: 1186-1189.
11. Alba-Roth J, Albrecht Muller O, Schopohl J, Von Werder K. Arginine stimulates growth hormone secretion by suppressing endogenous somatostatin secretion. J Clin Endocrinol Metab 1988; 67: 1186-1189.
12. Ghigo E, Arvat E, Valente F, Nicolosi M, Boffano GM, Procopio M, Bellone J, Maccario M, Mazza E, Camanni F. Arginine reinstates the somatotrope responsiveness to intermittent growth hormone-releasing hormone administration in normal adults. Neuroendocrinology 1991; 54: 291-294.
13. Ghigo E, Miola C, Aimaretti G, Valente F, Procopio M, Arvat E, Yin-Zhang W, Camanni F. Arginine abolishes the inhibitory effect of glucose on the growth hormone response to growth hormone-releasing hormone in man. Metabolism 1992; 41: 1000-1003.
14. Ghigo E, Ceda GP, Valcavi R, Goffi S, Zini M, Mucci M, Valenti G, Cocchi D, Muller EE, Camanni F. Low doses of either intravenously or orally administered arginine are able to enhance growth hormone response to growth hormone releasing hormone in elderly subjects.
15. Ghigo E, Goffi S, Nicolosi M, Arvat E, Valente F, Mazza E, Ghigo MC, Camanni F. GH responsiveness to combined administration of arginine and GHRH does not vary with age in man. J Clin Endocrinol Metab 1990; 71: 1481-1485.
16. Maccario M, Procopio M, Loche S, Cappa M, Martina V, Camanni F, Ghigo E. Interaction of free fatty acids on arginine on growth hormone secretion in man. Metabolism 1994; 43: 223-226.
17. Friesen H, Webster BR, Hwang P, Guyda H, Munro RE, Read L. Prolactin synthesis and secretion in a patient with the Forbes Albright syndrome. J Clin Endocrinol Metab 1972; 34: 192-199.
18. Rakoff JS, Siler TM, Sinha YN, Yen SSC. Prolactin and growth hormone release in response to sequential stimulation by arginine and synthetic TRF. J Clin Endocrinol Metab 1973; 37: 641-644.
19. Palmer JP, Walter RM, Ensinck JW. Arginine-stimulated acute phase of insulin and glucagon secretion. I. In normal man. Diabetes 1975; 24: 735-740.
20. Fajans SS, Floyd JC, Knopf RF, Conn JW. Effect of amino acids and proteins on insulin secretion in man. Rec Prog Horm Res 1967; 23: 617-656.
21. Floyd JC, Fajans SS, Conn JW, Knopf RF, Rull J. Stimulation of insulin secretion by amino acids. J Clin Invest 1966; 45: 1487-1502.
22. Carlson HE. Prolactin stimulation by protein is mediated by amino acids in humans. J Clin Endocrinol Metab 1989; 69: 7-14.
23. Page MD, Diguez C, Valcavi R, Edwards C, Hall R, Scanlon MF. GH response to arginine and L-dopa alone and after GHRH pretreatment. Clin Endocrinol (Oxf) 1988; 28: 551-554.
24. Vance ML, Kaiser DL, Evans WS, Furlanetto R, Vale W, Rivier J, Thorner MO. Pulsatile growth hormone secretion in normal man during a continuous 24-hours infusion of human growth hormone releasing-factor (1-40). Evidence for intermittent somatostatin secretion. J Clin Invest 1985; 75: 1584-1590.
25. Blachier F, Mourtada A, Sener A, Malaisse JW Stimulus-secretion coupling arginine-induced release. Uptake of metabolized and nonmetabolized cationic amino acids by pancreatic islets. Endocrinology 1989; 124: 134-141.