H,K-ATPase

Current Opinion in Nephrology and Hypertension

Volumn 5, Issue 5, 1996, Pages 411-416

  DuBose Jr , Thomas D ^a   Codina, Juan ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE;

HUMAN; KIDNEY COLLECTING TUBULE; NONHUMAN; PRIORITY JOURNAL; REVIEW;

EID: 10544242535     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041552-199609000-00006     Document Type: Review

References (36)

1. +-ATPase: structure, function, and regulation. Miner Electrolyte Metab (in press). This is an excellent and comprehensive review which outlines recent advances in the molecular characterization of H,K-ATPases.
2. Grishin AV, Sverdlov VE, Kostina MB, Modyanov NN: Cloning and characterization of the entire cDNA encoded by ATP1AL1 a member of the human Na,K/H,K-ATPase gene family. FEBS Lett 1994, 349:144-150.
3. Wingo CS, Smolka AJ: Function and structure of H-K-ATPase in the kidney. Am J Physiol 1995, 269:F1-F16. This is a detailed review with the emphasis on functional aspects of H,K-ATPase in collecting duct segments. It presents an interesting hypothesis on the role of apical H,K-ATPase in the recycling of potassium under potassium-replete conditions.
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9. Lee JS, Rajendran VM, Mann AS, Kashgarian M, Binder HJ: Functional expression and segmental localization of rat colonic K-adenosine triphosphatase. J Clin Invest 1995, 96:2002-2008. This was the first study to express HKα2 without coexpression of an exogenous β-subunit into baculovirus-infected S/9 cells which bestowed K-ATPase activity resistant to 1 mmol/l ouabain, but inhibited modestly by high concentrations (100 μmol/l) Sch 28080.
10. •], which employed the baculovirus expression system.
11. +-ATPase in X. laevis oocytes [Abstract]. Proc Texas Soc Acad Nephrol 1996, 1:20.
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13. Horisberger JD, Juanini P, Reugen MA, Lasater LS, Chow DC, Forte JG, Sachs G, Rossier BC, Geering K: The H,K-ATPase β-subunit can act as a surrogate for the β-subunit of NaK-pumps. J Biol Chem 1991, 266:19131-19134.
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15. Náray-Fejes-Tóth A, Fejes-Tóth G: Opposite regulation of 31 KD H-ATPase and colonic H-K-ATPase expression by metabolic acidosis and alkalosis in the cortical collecting duct (CCD) [Abstract]. J Am Soc Nephrol 1994, 5:257.
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20. Ahn KY, Kim KK, Kone BC: Effects of chronic hypokalemia of renal expression of 'gastric' H/K-ATPase α subunit gene. Am J Physiol 1996, 270:F557-F566. The cellular distribution and relative abundance of mRNA encoding HKα1 were examined in control and potassium-deplete rat kidney, using in-situ hybridization and competitive polymerase chain reaction. The results suggest that chronic potassium restriction is associated with modestly enhanced expression of gastric isoform, but that this apparent adaptation is confined to cortical segments.
21. Jaisser F, Escoubet B, Coutry N, Eugene E, Bonvalet JP: Differential regulation of putative K-ATPase at low K diet and corticosteroids in rat distal colon and kidney. Am J Physiol (in press).
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24. Zhou X, Wingo CS: Mechanisms of rubidium permeation by rabbit cortical collecting duct during potassium restriction. Am J Physiol 1992, 263:F1134-F1141.
25. + depletion. Am J Physiol 1996, 270:F116-F122.
26. Silver RB, Mennitt PA, Satlin LM: Stimulation of apical H-K-ATPase in intercalated cells of cortical collecting duct with chronic metabolic acidosis. Am J Physiol 1996, 270:F539-F547.
27. +-ATPase in rabbit cortical collecting duct B-type intercalated cell. Am J Physiol 1996, 270:F518-F530. This article reports an intriguing new observation suggesting a role of H,K-ATPase in B-type intercalated cell function.
28. +-ATPase [Abstract]. J Am Soc Nephrol 1995, 6:316.
29. + deprivation. Am J Physiol 1991, 260:F800-F805.
30. Younes-Ibrahim M, Barlet-Bas C, Buffin-Meyer B, Cheval L, Rajerison R, Doucet A: Ouabain-sensitive and -insensitive K-ATPases in rat nephron: effect of K depletion. Am J Physiol 1995, 268:F1141-F1147.
31. Rauchman MI, Nigam SK, Delpire E, Gullans SR: An osmotically tolerant inner medullary collecting duct cell line from an SV40 transgenic mouse. Am J Physiol 1993, 265:F416-F424.
32. i regulation in inner medullary collecting duct cells in culture. Am J Physiol 1996, 270:F852-F861. This article reports that intracellular pH regulation in the inner medullary collecting duct is, partly, the result of an H,K-ATPase, confirming the report in [33]. The study localized HKα1 and HKα2 to inner medullary collecting duct cells by Northern blot analysis.
33. +-ATPase of rat inner medullary collecting duct in primary culture. Am J Physiol 1993, 265:F698-F704.
34. i cells [Abstract]. J Invest Med 1995, 43:353.
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36. Madsen KM, Tisher CC: Structural-functional relationship along the distal nephron. Am J Physiol 1986, 250:F1-F15.