Prevention with sucralfate gel of NSAID-induced gastroduodenal damage in arthritic patients

American Journal of Gastroenterology

Volumn 91, Issue 11, 1996, Pages 2367-2371

  Miglioli, M ^b   Bianchi Porro, G ^b   Vaira, D ^a   Menegatti, M ^b   Brunetti, G ^b   Petrillo, M ^b   Ardizzone, S ^b   Frizziero, L ^b   Montrone, F ^b   Grandinetti, G ^b  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

DICLOFENAC; GASTROGEL; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; SUCRALFATE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTHRITIS; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DUODENUM INJURY; EPIGASTRIC PAIN; FEMALE; HEARTBURN; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STOMACH EROSION; STOMACH PROTECTION;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTI-ULCER AGENTS; ARTHRITIS, RHEUMATOID; DICLOFENAC; DOUBLE-BLIND METHOD; DUODENAL ULCER; FEMALE; GELS; HUMANS; MALE; MIDDLE AGED; NAPROXEN; OSTEOARTHRITIS; STOMACH ULCER; SUCRALFATE;

EID: 10544233362     PISSN: 00029270     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Hollander D. Gastrointestinal complications of nonsteroidal anti-inflammatory drugs: Prophylactic and therapeutic strategies. Am J Med 1994;96:274-81.
2. Baum C, Kennedy GL, Forbes MB. Utilization of nonsteroidal anti-inflammatory drugs. Arthritis Rheum 1985;28:686-92.
3. Hawkey CJ. Nonsteroidal anti-inflammatory drugs and peptic ulcers. Facts and figures multiply, but do they add up? Br Med J 1990;300: 278-84.
4. Gabriel SE, Jaakminainen L, Bombardier C. Risk for serious gastrointestinal complications related to use of nonsteroidal anti-inflammatory drugs - a meta-analysis. Ann Intern Med 1991;115:787-96.
5. Lanza FL. A review of gastric ulcer and gastroduodenal injury in normal volunteers receiving aspirin and other nonsteroidal anti-inflammatory drugs. Scand J Gastroenterol 1989;24(Suppl 163):24-31.
6. Caruso I, Bianchi Porro G. Gastroscopic evaluation of anti-inflammatory agents. Br Med J 1980;280:75-8.
7. Sommerville K, Faulkner G, Langman M. Nonsteroidal anti-inflammatory drugs and bleeding peptic ulcer. Lancet 1986;1:462-4.
8. Fenn GC. Review article: Controversies in NSAID-induced gastroduodenal damage - do they matter? Aliment Pharmacol Ther 1994;8:15-26.
9. Rainsford KD. Mechanisms of gastrointestinal toxicity of nonsteroidal anti-inflammatory drugs. Scand J Gastroenterol 1989;24(Suppl 163): 9-16.
10. Bugat R. Gastric mucosal lesions produced by intravenous infusion of aspirin in cats. Gastroenterology 1976;71:754-9.
11. Lanza FL, Karlin DA, Yee JP. A double-blind placebo controlled endoscopic study comparing the mucosal injury seen with orally and parenterally administered nonsteroidal analgesic ketorolac tromethamine at therapeutic and supratherapeutic doses. Am J Gastroenterol 1987;82:939 (abstract).
12. Willett LR, Carson JL, Strom BL. Epidemiology of gastrointestinal damage associated with nonsteroidal anti-inflammatory drugs. Drug Safety 1994;10:170-81.
13. Garcia Rodriguez LA, Jick H. Risk of upper gastrointestinal bleeding and perforation associated with nonsteroidal anti-inflammatory drugs. Lancet 1994;343:769-72.
14. Bateman DN. NSAIDs: Time to re-evaluate gut toxicity. Lancet 1994; 343:1051-2.
15. Langman MJS, Weilm J, Wainwright P, et al. Risks of bleeding peptic ulcer associated with individual nonsteroidal anti-inflammatory drugs. Lancet 1994;343:1075-8.
16. Lanza FL, Royer GL. NSAID-Induced gastric ulceration is dose related by weight: An endoscopic study with Flubiprofen. Am J Gastroenterol 1993;88:683-6.
17. McCarthy DM. Nonsteroidal anti-inflammatory drugs: The clinical dilemma. Scand J Gastroenterol 1992;27(Suppl 192):9-16.
18. Hollander D, Tarnawski A. Mechanisms of protective and therapeutic action of sucralfate. In: Bianchi Porro G, Holllander D, eds. Treatment of Digestive Disease with Sucralfate. Verona, Italy: Cortina International, 1989:7-11.
19. McCarthy DM. Sucralfate. N Engl J Med 1991;325:1017-25.
20. Vaira D, Corbelli C, Brunetti G, et al. Gastric retention of sucralfate gel and suspension in upper gastrointestinal diseases. Aliment Pharmacol Ther 1993;7:531-5.
21. Rossi S, Banferroni MC, Caramella C, et al. Rheological study of sucralfate humid gel: A contribution to the comprehension of its stability properties. Eur J Pharm Biopharm 1992;38:78-81.
22. Guslandi M, Sorghi M, Foppa A, et al. Effect of a gel formulation of sucralfate on gastric microcirculation. J Int Med Res 1993;21:47-50.
23. Lanza FL, Kochman RL, Geis GS, et al. A double-blind, placebo-controlled, 6-day evaluation of two doses of misoprostol in gastroduodenal mucosal protection against damage from aspirin and effect on bowel habits. Am J Gastroenterol 1991;86:1743-8.
24. Stem AI, Ward F, Hartley G. Protective effect of sucralfate against aspirin-induced damage to the human gastric mucosa. Am J Med 1987;83(Suppl 3B):83-5.
25. Konturek SJ, Swiecien N, Obtulowicz W, et al. Gastroprotection by sucralfate against acetylsalicylic acid in humans. Role of endogenous prostaglandins. Scand J Gastroenterol 1987;22(Suppl 140):19-22.
26. Tesler MA, Lim ES. Protection of gastric mucosa by sucralfate from aspirin-induced erosions. J Clin Gastroenterol 1981;3(Suppl 2):175-9.
27. Lanza FL, Graham DY, Davis RE, et al: Endoscopic comparison of cimetidine and sucralfate for prevention of naproxen-induced acute gastroduodenal injury. Effect of scoring method. Dig Dis Sci 1990; 35:1494-9.
28. Malchow-Moller A, Ranlov PJ. Does sucralfate reduce acetylsalicylic-acid-induced gastric mucosal bleeding? Scand J Gastroenterol 1987; 22:550-2.
29. Wu WC, Castell DO. Does sucralfate protect against aspirin-induced mucosal lesions? Yes and no! Gastroenterology 1984;86:A1303 (abstract).
30. Stern AI, Ward F, Sievert W. Lack of gastric mucosal protection by sucralfate during long-term aspirin ingestion in humans. Am J Med 1989;86(Suppl 6A):66-9.
31. Hallas J, Lauritsen J, Dalsgard Villadsen H, et al. Nonsteroidal anti-inflammatory drugs and upper gastrointestinal bleeding, identifying high-risk groups by excess risk estimates. Scand J Gastroenterol 1995; 30:438-44.
32. Graham DY, Smith LJ, Spjut HJ, et al. Gastric adaptation. Studies in humans during continuous aspirin administration. Gastroenterology 1988;95:327-33.
33. Konturek SJ, Konturek JW. Gastric adaptation: Basic and clinical aspects. Digestion 1994;55:131-8.