Synthesis and assembly of chimeric human immunodeficiency virus gag pseudovirions

Intervirology

Volumn 39, Issue 1-2, 1996, Pages 40-48

  Tobin, Gregory J ^a   Nagashima, Kunio ^a   Gonda, Matthew A ^a  

^a SAIC FREDERICK INC   (United States)

Author keywords

Baculovirus; Human immunodeficiency virus; Immunoelectron microscopy; Particulate vaccines; Pseudovirion; Virus like particle

Indexed keywords

EPITOPE; GAG PROTEIN; VIRUS FUSION PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BACULOVIRUS; CONTROLLED STUDY; CYTOTOXIC LYMPHOCYTE; ELECTRON MICROSCOPY; ENVELOPE GENE; FRAMESHIFT MUTATION; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOBLOTTING; INSECT; MOUSE; NONHUMAN; PRIORITY JOURNAL; VIRION; VIRUS ASSEMBLY; VIRUS GENE; VIRUS IMMUNITY;

ANIMALS; FRAMESHIFT MUTATION; GENE EXPRESSION; GENE PRODUCTS, ENV; GENE PRODUCTS, GAG; HIV; HUMANS; PROTEIN PRECURSORS; RECOMBINANT FUSION PROTEINS; VIRUS ASSEMBLY;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; INSECTA; UNIDENTIFIED BACULOVIRUS;

EID: 10544230643     PISSN: 03005526     EISSN: 14230100     Source Type: Journal    
DOI: 10.1159/000150473     Document Type: Article

References (43)

1. Levy JA: Pathogenesis of human immunodeficiency virus infection, Microbiol Rev 1993;57: 183-289.
2. Hoth DF, Bolognesi DP, Corey L, Vcrmund SH: NIH conference, HIV vaccine development: A progress report, Ann Intern Med 1994; 121:603-611.
3. Dcsrosiers RC: Safety issues facing development of a live-attenuated, multiply deleted HIV-1 vaccine, AIDS Res Hum Retroviruses 1994:10:331-332.
4. Salk J: Prospects for the control of AIDS by immunizing seropositive individuals, Nature 1987:327:473-476.
5. Daar ES, Moudgil T, Meyer RD, Ho DD: Transient high levels of vircmia in patients with primary' human immunodeficiency virus type I infection, N Engl J Med 1991:324:961-964.
6. Graziosi C, Pantalco G, But ini L, Dentarest JF, Saag MS, Shaw GM, Fauci AS: Kinetics of human immunodeficiency virus type 1 (HIV-l) DNA and RNA synthesis during primary HI V-1 infection, Proc Natl Acad Sci USA 1993:90: 6405-6409.
7. Borrow P, Lewicki H, Hahn BH, Shaw GM, Oldstonc MB: Virus-specific CD8+ cytotoxic T-lymphocyle activity associated with control of viremia in primary human immunodeficiency virus type I infection, J Virol 1994:68: 6103-6110.
8. Pantalco G, Demarcst JF, Soudeyns H, Graziosi C, Denis F, Adelsberger JW, Borrow P, Saag MS, Shaw GM, Sekaly RP, Fauci AS: Major expansion ofCD8+ T cells with a predominant V beta usage during the primary immune response to HIV, Nature 1994:370:463-467.
9. Koup RA, Safrit JT, Cao Y, Andrews CA, McLeod G, Borkowsky W, Farthing C, Ho DD: Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome, J Virol 1994:68:4650-4655.
10. Cao Y, Qin L, Zhang L, Safrit J, Ho DD: Viro-logic and immunologic characterization of long-term survivors of human immunodeficiency virus type 1 infection, N Engl J Med 1995:332:201-208.
11. Klein MR, van Baalen CA, Holwcrda AM, Kerkhof Garde SR, Bende RJ, Keet IP, Ecf-tinck-Schattcnkcrk JK, Osterhaus AD, Schuite-ntaker H, Micdcma F: Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: A longitudinal analysis of rapid progressors and long-term asvmptomatics, J Exp Med 1995; 181:1365- 1372.
12. McFarland EJ, Curiel TJ, Schoen DJ, Rosan-dich ME, Schooley RT, Kuritzkcs DR: Cytotoxic T lymphocyte lines specific for human immunodeficiency virus type 1 Gag and reverse transcriptase derived from a vertically infected child, J Infect Dis 1993:167:719-723.
13. Madisen L, Travis J, Hu SL, Purchio AF: Expression of the human immunodeficiency virus gag gene in insect cells, Virology 1987; 158:248-250.
14. a8 viruslike particles from recombinant baculovirus-infccted insect cells, Cell 1989;59:103-112.
15. Karacostas V, Nagashinta K, Gonda MA, Moss B: Human immunodeficiency virus-like particles produced by a vaccinia virus expression vector, Proc Natl Acad Sci USA 1989:86: 8964-8967.
16. Delchambre M, Gheysen D, Thines D, Thiriart C, Jacobs E, Verdin E, Horth M, Burney A, Bex F: The Gag precursor of simian immunodeficiency virus assembles into virus-like particles, EMBOJ 1989;8:2653-2660.
17. Rasmussen L, Battles JK, Ennis WH, Nagashi-ma K, Gonda MA: Characterization of viruslike particles produced by a recombinant bacu-lovirus containing the gag gene of the bovine immunodeficiency-like virus, Virology 1990: 178:435-451.
18. Morikawa S, Booth TF, Bishop DHL: Analyses of the requirements for the synthesis of viruslike particles by feline immunodeficiency virus gag using baculovirus vectors, Virology 1991: 183:288-297.
19. Karacostas V, Wolffe EJ, Nagashinta K, Gonda MA, Moss B: Overexpression of the HIV-1 gag-pol polyprotein results in intracellular activation of HIV-1 protcase and inhibition of assembly and budding of virus-like particles, Virology 1993:193:661-671.
20. Wagner R, Fliessbach H, Wanner G, Motz M, Nicdrig M, Deby G, von Brunn A, Wolf H: Studies on processing, particle formation, and immunogcnicity of the HIV-1 gag gene product: A possible component of a HIV vaccine, Arch Virol 1992:127:117-137.
21. Tobin GJ, Battles JK, Rasmussen L, Gonda MA: Assembly of recombinant retroviral Gag precursors into pseudovirions in the baculovi-rus-insect cell expression system: in Adolph KW (ed): Methods in Molecular Genetics, Molecular Virology, Orlando, Academic Press, 1995, vol 7, pp 237-253.
22. Luo L, Li Y, Cannon PM, Kim S, Kang CY: Chimeric gag-V3 virus-like particles of human immunodeficiency virus induce virus-neutralizing antibodies, Proc Natl Acad Sci USA 1992;89:10527-10531.
23. Wagner R, Demi L, Flicssbach H, Wanner G, Wolf H: Assembly and extracellular release of chimeric HIV-1 Pr55gag retrovirus-like particles, Virology 1994:200:162-175.
24. Wang CT, Stegeman-Olsen J, Zhang Y, Barklis H: Assembly of HIV GAG-B-galactosidasc fusion proteins into virus particles, Virology 1994:200:524-534.
25. Olshevsky U, Helscth E, Furman C, Li J, Ha-seltine W, Sodroski J: Identification of individual human immunodeficiency virus type 1 gpl20 amino acids important forCD4 receptor binding, J Virol 1990:64:5701-5707.
26. Cordonnier A, Montagnicr L, Emcrman M: Single amino-acid changes in HIV envelope affect viral tropism and receptor binding, Nature 1989;340:571-574.
27. Potts BJ, Field KG, Wu Y, Posncr M, Cavacini L, White-Scharf M: Synergistic inhibition of HIV-1 by CD4 binding domain reagents and V3-directed monoclonal antibodies, Virology 1993:197:415-419.
28. Ratto S, Sitz KV, Scherer AM, Manca F, Loomis LD, Cox JIL Redfield RR, Birx DL: Establishment and characterization of human immunodeficiency virus type I (HIV-1) envelope-specific CD4+ lymphocyte lines from HIV-l-scropositivc patients, J Infect Dis 1995: 171:1420-1430.
29. Sodroski J, Kowalski M, Haseltine W: Structure and function of the HIV envelope: Implications for vaccine development; in Putney SD, Bolognesi DP (eds): AIDS Vaccine Research and Clinical Trials, New York, Dekkcr, 1990, pp 93-106.
30. Tobin GJ, Nagashima K, Gonda MA: Immunologic and ultrastructural characterization of HIV pseudovirions containing Gag and Env precursor proteins engineered in insect cells, Methods 1996:10:208-218.
31. Summers MD, Smith GE: A Manual of Methods for Baculovirus Vectors and Insect Cell Culture Procedures, Texas Agricultural Experiment Station Bulletin No, 1555, College Station, Texas Agricultural Experiment Station, 1987.
32. Gonda MA, Wong-Staal F, Gallo RC, Clements JE, Narayan O, Gilden RV: Sequence homology and morphologic similarity of HTLV-II1 and visna virus, a pathogenic lcnti-virus, Science 1985;227:173-177.
33. Hu SL, Kosowski SG, Schaaf KF: Expression of envelope glycoproteins of human immunodeficiency virus by an insect virus vector, J Virol 1987;61:3617-3620.
34. Wells DE, Compans RW: Expression and characterization of a functional human immunodeficiency virus envelope glycoprotein in insect cells, Virology 1990:176:575-586.
35. Gonda MA: Immunoclectron microscopy; in van Oss CJ, Van Regenmortel MHV (eds): Immunochemistry, New York, Dekkcr, 1994, pp 867-902.
36. Jacks T, Madhani HD, Masiarz FR, Varmus HE: Signals for ribosomal frameshifting in Rous sarcoma virus gag-pol region, Cell 1988; 55:447-458.
37. Vamius H: Retroviruses, Science 1988:240: 1427-1435.
38. Battles JK, Hu MY, Rasmussen L, Tobin GJ, Gonda MA: Immunological characterization of the gag gene products of bovine immunodeficiency virus, J Virol 1992:66:6868-6877.
39. Gonda MA, Oberste MS: AIDS - The human immunodeficiency virus: Molecular and structural aspects of its biology; In Kurstak E (ed): Control of Virus Diseases, New York, Dekkcr, 1992, pp 3-31.
40. Griffiths JC, Harris SJ, Layton GT, Bcrric EL, French TJ, Bunts NR, Adams SE, Kingsntan AJ: Hybrid human immunodeficiency virus Gag particles as an antigen carrier system: Induction of cytotoxic T-cell and humoral responses by a Gag:V3 fusion, J Virol 1993:67: 3191-3198.
41. von Poblotzki A, Wagner R, Nicdrig M, Wanner G, Wolf H, Modrow S: Identification of a region in the Pr55gag-polyprotein essential for HIV-1 particle formation, Virology 1993:193: 981-985.
42. Hong SS, Boulanger P: Assembly-defective point mutants of the human immunodeficiency virus type 1 Gag precursor phenotvpically expressed in recombinant baculovirus-infccted cells, J Virol 1993;67:2787-2798.
43. Parkin NT, Chamorro M, Varmus HE: Human immunodeficiency virus type 1 gag-pol frame-shifting is dependent on downstream mRNA secondary structure: Demonstration by expression in vivo, J Virol 1992;66:5147-5151.