Control of L-phenylalanine production by dual feeding of glucose and L- tyrosine

Biotechnology and Bioengineering

Volumn 52, Issue 6, 1996, Pages 653-660

  Takagi, Mutsumi ^a   Nishio, Yoshinori ^a   Oh, Gyuseop ^a   Yoshida, Toshiomi ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

dual feeding; feeding control; glucose feeding; glucose uptake rate; L phenylalanine production; L tyrosine feeding

Indexed keywords

ACETIC ACID; AMINES; AMINO ACIDS; BACTERIA; BATCH CELL CULTURE; BIOSENSORS; BIOSYNTHESIS; ENZYMES; GLUCOSE; LASER APPLICATIONS;

CHORISMATE MUTASE PREPHENATE DEHYDRATASE; DEOXYARABINOHEPUTULOSONATE PHOSPHATE SYNTHASE; ESCHERICHIA COLI; LASER SENSOR; MAXIMUM GLUCOSE UPTAKE RATE; PHENYLALANINE; TYROSINE;

BIOTECHNOLOGY;

CHORISMATE MUTASE; GLUCOSE; PHENYLALANINE; TYROSINE;

AEROBIC METABOLISM; AMINO ACID METABOLISM; ARTICLE; CELL GROWTH; ENERGY BALANCE; ENZYME ACTIVITY; FEEDING; FERMENTATION; GLUCOSE INTAKE; GLUCOSE TRANSPORT; NONHUMAN; PROMOTER REGION;

ESCHERICHIA COLI;

EID: 10544228519     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(19961220)52:6<653::AID-BIT3>3.3.CO;2-3     Document Type: Article

References (17)

1. Akashi, K., Shibai, H., Hirose, Y. 1979. Effect of oxygen supply on L-phenylalanine, L-proline, L-glutamine and L-arginine fermentations. J. Ferment. Technol. 57: 321-327.
2. Choi, Y. J., Tribe, D.E. 1982. Continuous production of phenylalanine using an Escherichia coli regulatory mutant Biotechnol. Lett. 4: 223-228.
3. Cotton, R. G., Gibson, F. 1970. Tyrosine and L-phenylalanine biosynthesis: The T and P proteins (Aerobacter aergenes); chorismate mutase (Pisum sativum). Methods Enzymol. 17A: 564-574.
4. de Boer, L., Dijkhuizen, L. 1990. Microbial and enzymatic processes for L-phenylalanine production. Adv. Biochem. Eng. Biotechnol. 41: 1-27.
5. Field, R. 1971. The measurement of amino groups in proteins and peptides. Biochem. J. 124: 581-590.
6. Forberg, C., Eliaeson, T., Haggstrom. L. 1988. Correlation of theoretical and experimental yields of phenylalanine from non-growing cells of rec Escherichia coli strain. J. Biotechnol. 7: 319-332.
7. Forberg, C., Haggstrom, L. 1988. Phenylalanine production from rec Escherichia coli-strain in fed-batch culture. J. Biotechnol. 8: 291-300.
8. Gollub, E., Zalkin, H., Sprinson, D. B. 1970. Assay for 3-deoxy-D-arabinoheptulosonic acid 7-phosphate synthase. Methods Enzymol. 17A: 349-350.
9. Hwang, S. O., Gil, G. H., Cho, Y. J., Kang, K. R., Lee, J. H., Bae, J. C. 1985. The fermentation process for L-phenylalanine production using an auxotrophic regulatory mutant of Escherichia coli. Appl. Microbiol. Biotechnol. 22: 108-113.
10. Konstantinov, K. B., Kishimoto. M., Seki, T., Yoshida, T. 1990a. A balanced DO-stat and its application to the control of acetic acid expression by recombinant Escherichia coli. Biotechnol. Bioeng. 36: 750-758.
11. Konstantinov, K. B., Nishio, N., Yoshida, T. 1990b. Glucose feeding strategy accounting for the decreasing oxidative capacity of recombinant Escherichia coli in fed-batch cultivation for phenylalanine production. J. Ferment. Bioeng. 70: 253-260.
12. Konstantinov, K. B., Yoshida, T. 1990. On-line monitoring of representative structural variables in fed-batch cultivation of recombinant Escherichia coli for phenylalanine production. J. Ferment. Bioeng. 70: 421-427.
13. Lowry, H. O., Rosebrough, N. J., Farr, A. L., Randall, R. J. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265-275.
14. Sano, K., Shiio, I. 1967. Microbial production of L-lysine. I. Production by auxotrophs of Brevibacterium flavum. J. Gen. Appl. Microbiol. 13: 349-358.
15. Sugimoto, S., Kato, N., Kitaoka, Y., Seki, T., Yoshida, T., Taguchi, H. 1990. Phenylalanine production by periodic induction of gene expression using a temperature-distributed dual fermentor system. J. Ferment. Bioeng. 70: 376-380.
16. Sugimoto, S., Seki, T., Yoshida, T., Taguchi, H. 1986. Intentional control of gene expression by temperature using the repressor-promoter system of bacteriophage lambda. Chem. Eng. Commun. 45: 241-253.
17. Sugimoto, S., Yabuta, M., Kato, N., Seki, T., Yoshida, T., Taguchi, H. 1987. Hyperproduction of phenylalanine by Escherichia coli: Application of temperature-controllable expression vector carrying the repressor-promoter system of bacteriophage lambda. J. Biotechnol. 5: 237-253.