Harziphilone and fleephilone, Two new HIV REV/RRE binding inhibitors produced by Trichoderma harzianum

Journal of Antibiotics

Volumn 49, Issue 10, 1996, Pages 990-997

  Qian Cutrone, Jingfang ^a   Huang, Stella ^a   Chang, Li Ping ^a   Pirnik, Dolores M ^a   Klohr, Steven E ^a   Dalterio, Richard A ^a   Hugill, Robert ^a   Lowe, Susan ^a   Alam, Masud ^a   Kadow, Kathleen F ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; FLEEPHILONE; HARZIPHILONE; REV PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBIOTIC BIOSYNTHESIS; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG POTENCY; DRUG STRUCTURE; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPHOMYCETES; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN BINDING; PROTON NUCLEAR MAGNETIC RESONANCE; RNA BINDING; TAXONOMY; TUMOR CELL LINE;

EID: 10544223742     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.49.990     Document Type: Article

References (14)

1. ZAPP, M. L.; T. J. HOPE, T. G. PARSLOW & M. R. GREEN: Oligomerization and RNA binding domains of the type 1 human immunodeficiency virus Rev protein: A dual function for an arginine-rich binding motif. Proc. Natl. Acad. Sci. U.S.A. 88: 7734-7738, 1991
2. BARTEL, D. P; M. L. ZAPP, M. R. GREEN & J. W. SZOSTAK: HIV-1 Rev regulation involves recognition of non-Watson-Crick base pairs in viral RNA. Cell 67: 529-536, 1991
3. DALY, T. J.; K. S. COOK, G. S. GRAY, T. E. MALONE & J. R. RUSCHE: Specific binding of HIV-1 recombinant Rev protein to the Revresponsive element in vitro. Nature 342: 816-819, 1989
4. BARNETT, H. L. & B. B. HUNTER: Illustrated Genera of Imperfect Fungi, 4th edition. McMillan Publishing Co., New York, 1972
5. RIFAI, M. A.: A revision of the genus Trichoderma. Mycological Papers 116: 1-56, 1969
6. ZAPP, M. L. & M. R. GREEN: Sequence-specific RNA binding by the HIV-1 Rev protein. Nature 342: 714-716, 1989
7. ZAPP, M. L.; S. STERN & M. R. GREEN: Small molecules that selectively block RNA binding of HIV-1 Rev protein inhibit Rev function and viral production. Cell 74: 969-978, 1993
8. HEAPHY, S.; C. DINGWALL, I. ERNBERG, M. J. GAIT, S. M. GREEN, J. KARN, A. D. LOWE, M. SINGH & M. A. SKINNER: HIV-1 Regulator of virion expression (Rev) protein binds to an RNA stem-loop structure located within the Rev response element region. Cell 60: 685-693, 1990
9. SCHROEDER, H. C.; H. USHIJIMA, A. BEK, H. MERZ, K. PFEIFER & W. E. G. MULLER: Inhibition of formation of Rev-RRE complex by pyronin Y. Antiviral Chemistry and Chemotherapy 4(2): 103-111, 1993
10. WEISLOW, O. S.; R. KISER, D. L. FINE, J. BADER, R. J. SHOWMAKER & M. R. BOYD: New soluble-formazan assay for HIV-1 cytopathic effects: Application to high-flux screening of synthetic and natural products for AIDS-antiviral activity. J. Natl. Can. Inst. 81: 577-586, 1989
11. MARKS, T. A.; R. J. WOODMAN, R. I. GERAN, L. H. BILLUPS & R. M. MADISON: Characterization and responsiveness of the Madison 109 lung carcinoma to various anti-tumor agents. Cancer Threat. 61: 1459-1470, 1977
12. MCBRIEN, K. D.; R. BERRY, S. E. LOWE, K. NEDDERMANN, I. BURSUKER, S. HUANG, S. E. KLOHR & J. E. LEET: Rakicidins, new cytotoxic lipopeptides from Micromonospora sp.: Fermentation, isolation and characterization. J. Antibiotics 48: 1446-1452, 1995
13. HOOK, D. J.; C. F. MORE, J. J. YACOBUCCI, G. DUBAY & S. O'CONNOR: Intergrated biological-physicochemical system for the identification of antitumor compounds in fermentation broths. J. Chromatography 385: 99-108, 1987
14. 1H NMR spectroscopy: A general comment. Collection Czechoslov. Chem. Commun. 44: 558-588, 1979