On a dual role for clonidine stimulation of the ventromedial nucleus of the hypothalamus in sodium and potassium renal excretions of rats

Pharmacology

Volumn 53, Issue 5, 1996, Pages 281-288

  Saad, Wilson Abrão ^a   de Arruda Camargo, Gabriela Pavan ^a   de Arruda Camargo, Luiz Antonio ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Clonidine; Potassium excretion; Prazosin; Sodium excretion; Ventromedical nucleus, hypothalamus; Yohimbine

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 2A ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; CLONIDINE; POTASSIUM ION; PRAZOSIN; SODIUM ION; YOHIMBINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; INTRACEREBRAL DRUG ADMINISTRATION; KALIURESIS; MALE; NATRIURESIS; NONHUMAN; POTASSIUM URINE LEVEL; PRIORITY JOURNAL; RAT; SODIUM URINE LEVEL; STIMULATION; THALAMUS VENTRAL NUCLEUS;

EID: 10544222836     PISSN: 00317012     EISSN: 14230313     Source Type: Journal    
DOI: 10.1159/000139440     Document Type: Article

References (30)

1. Saito M, Minokoshi Y, Shimazu T: Accelerated norepinephrine turnover in peripheral tissues alter ventromedial hypothalamic stimulation in rats. Brain Res 1989:481:298-303.
2. Shimazu T: Neuronal control of intermediate metabolism: in Light-man SL. Everitt BJ (eds): Oxford. Blackwell, 1986. pp 304-330.
3. Lcibowitz SF, Jhanwar-Uniyal M. Makman MH: Distribution of u-adrencrgic, 3-adrenergie and dopaminergic receptors in discrete hypothalamic areas of rat. Brain Res 1982:233:97-114.
4. Row L-M. Pfaff DW: Responses of ventromedial hypothalamic neurons in vitro to norepinephrine: Dependence on dose and receptor type. Brain Res 1987:413:220-228.
5. Fregly MJ. Kelleher DL: Antidip-sogenic effect of clonidine on isoproterenol induced water. Appetite 1980:1:279-289.
6. Fregly MJ, Kelleher DL. Greenleaf JF.: Antidipsogcnic effect of clonidine on antagonism II. hypertonic saline, pilocarpine and dehydration-induced water intake. Brain Res Bull 1986:7:661-664.
7. Fregly MJ. Rowland NE. Greenleaf JE: Clonidine antagonism of angiotensin-related drinking: A central site of action. Brain Res 1984,298: 321-327.
8. Saad WA. Camargo LAA. Saad WA: Effects of the application of di-and co-adrenoceptor agonist and antagonists into the ventromedial hypothalamus on the sodium and potassium renal excretion. Pharmacology 1984:28:228-234.
9. Paxinos G. Watson C: The Rat Brain in Stereotaxic Coordinates. San Diego, Academic Press, 1986.
10. Bylund DB, Ray-Prenger C, Murphy TJ: Alpha-2A and alpha-2B adrenergic receptor subtypes: Antagonist binding in tissues and cell lines containing only one subtype. J Pharmacol ExpThcr 1988:245:600-607.
11. Michel AD. LouryDN. Whiting RL: Differences between the co-ad reno-ceptor in rat submaxillary gland and the ajA-and a;n-adrenoceptor sub-types. Br J Pharmacol 1989:98:890-897.
12. Beckett PJ, Finch L: The ai-adreno-ccplor involvement in the central cardiovascular action of clonidine in the conscious renal hypertensive cat. EurJ Pharmacol 1982:82:155-160.
13. Ferrari AC. Camargo L.AA. Saad WA. Rcnzi A. De Luca LA Jr. Menani JV: Clonidine and phenylephrine injected into the lateral hypothalamus inhibit water intake in rats. Brain Res 1990;552:125-130.
14. Timmermans PBMWM. Lam E. Van Zwietcn PA: The interaction between prazosin and clonidine at u-adrcnoceptors in rats and cats. Eur J Pharmacol 1979:55:57-66.
15. Bylund DB: Subtypes of ai-and ai-adrenergic receptors. FASEB J 1992;6:832-839.
16. Bylund DB: Heterogeneity of alpha-2-adrcnergic receptors. Pharmacol Biochcm Bchav 1985;22:835-843.
17. Bylund DB: Subtypes of co-adrenoceptors: Pharmacological and molecular biological evidences converge. Trends Pharmacol Sci 1988; 9:356-361.
18. Nahorski SR. Barnett DB. Cheung YD: a-Adrenoceptor-cffector coupling: Affinity states or heterogeneity of the ci2-adrenoceptor? Clin Sci 1985;68(suppl 10):39-42.
19. Mouille P, Dabire B, Fournier B. Schmitt H: A further attempt to characterize the co-adrenoceptor blocking properties of (imidazolvl-2)-2-bcnzodioxanc 1-4(170 150) in pithed rats. Eur J Pharmacol 1981: 73:365-370.
20. Pettingcr WA: Pharmacology of clonidine. J C'ardiovasc Pharmacol 1980;2:521-528.
21. Reid JL. Tangri KK. Wing LMN: The central hypotensive action of clonidine and propranolol in animal and man. Prog Brain Res 1977:47: 369-383.
22. Ccdarbaum JM. Aghajanian CK: Catecholamine receptors on locus cocruleus: Pharmacological characterization. Eur J Pharmacol 1977: 44:375-385.
23. McCall RB. Schuette MR. Humphrey SJ. Lahti RA. Barsuhn C: Evidence for a central sympathoexcita-tory action of a-adrencrgic antagonists. J Pharmacol Exp Ther 1983; 224:501-507.
24. Leite DF. Camargo LAA. Saad WA. Renzi A, Fòglia S. De Luca LA Jr. Mcnani JV: Role of cholinergic and adrenergic pathways of the medial septal area in the control of water intake and renal excretion in rats. Pharmacol Biochem Behav 1992: 42:1-8.
25. Koepkc JP. Dibona GF: Central adrenergic control of renal function in conscious hypertensive rats. Hypertension 1986:8:133-141.
26. Patel KP: Central alpha-2-adrcner-gic mechanisms in the renal nerve mediated natriurcsis and diuresis produced by acute volume expansion. J Auton Ncrv Syst 1991:36: 47-54.
27. Emsberger P. Giuliano R, Villctte RN. Reis DJ: Role of imidazole receptors in the vasodepressor response to clonidinc analogs in the rostral ventral medulla. J Pharmacol Exp Ther 1990:253:408-418.
28. Emsberger P. Haxhiu MA. Graff LM. Collins LA, Dreshay I. Grove DL. Graves ME. Shafer SG, Christen MD: A novel mechanism of action of hypertension control: Mon-oxinidine as a selective Ii-imidazo-line agonist. Cardiovasc Drugs Ther 1994;8:27-41.
29. Emsberger P. Feiland G. Meclcy MP, Reis DJ: Characterization and visualization of clonidine-sensitive imidazole sites in rat kidney which recognize clonidinc-displacing substance. Am J Hypcrtcns 1990;30: 90-97.
30. Smyth DD. Li P, Blandford DE, Penner SB: Opposite rank order of potency for alpha-2 adrenoceptor agonists in water and solute excretion in the rat: Two sites for receptors. J Pharmacol Exp Ther 1992: 261:1080-1086.