Study of association between α-synuclein gene polymorphism and methamphetamine psychosis/dependence

Annals of the New York Academy of Sciences

Volumn 1025, Issue , 2004, Pages 325-334

  Kobayashi, Hideaki ^a,j   Ide, Soichiro ^a,b   Hasegawa, Junko ^a   Ujike, Hiroshi ^c,k   Sekine, Yoshimoto ^d,k   Ozaki, Norio ^e,k   Inada, Toshiya ^e,k   Harano, Mutsuo ^f,k   Komiyama, Tokutaro ^g,k   Yamada, Mitsuhiko ^h,k   Iyo, Masaomi ^i,k   Shen, Hao Wei ^a   Ikeda, Kazutaka ^a   Sora, Ichiro ^a,j,k  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c OKAYAMA UNIVERSITY   (Japan)

^d HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^f KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^g NATIONAL INSTITUTE OF MENTAL HEALTH   (Japan)

^h SHOWA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

ⁱ CHIBA UNIVERSITY   (Japan)

^j TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^k Japan Genet Initiative Drug Abuse   (Japan)

more..

Author keywords

Dopamine transporter; Mesolimbic dopaminergic pathway; Methamphetamine; synuclein

Indexed keywords

ALPHA SYNUCLEIN; DOPAMINE; DOPAMINE TRANSPORTER; METHAMPHETAMINE;

ADULT; COCAINE DEPENDENCE; COMPLEX FORMATION; CONFERENCE PAPER; CONTROLLED STUDY; DNA POLYMORPHISM; DOPAMINE UPTAKE; DRUG DEPENDENCE; DRUG MECHANISM; FEMALE; GENE FREQUENCY; GENE OVEREXPRESSION; GENETIC VARIABILITY; HUMAN; INTRON; MALE; MESENCEPHALON; POPULATION RESEARCH; PSYCHOSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 10444225476     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1316.040     Document Type: Conference Paper

References (19)

1. SPILLANTINNI, M.G., M.L. SCHMIDT, V.M.Y. LEE, et al. 1997. α-Synuclein in Lewy bodies. Nature 388: 839-840.
2. SPILLANTINI, M.G., R.A. CROWTHER, R. JAKES, et al. 1998. α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95: 6469-6473.
3. CLAYTON, D.F. & J.M. GEORGE. 1999. Synucleins in synaptic plasticity and neurodegenerative disorders. J. Neurosci. Res. 58: 120-129.
4. LEE, F.J., F. LIU, Z.B. PRISTUPA, et al. 2001. Direct binding and functional coupling of α-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis. FASEB J. 15: 916-926.
5. ZHOU, W., M.S. HURLBERT, J. SCHAACK, et al. 2000. Overexpression of human α-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells. Brain Res. 866: 33-43.
6. ZHOU, W., J. SCHAACK, W.M. ZAWADA, et al. 2002. Overexpression of human α-synuclein causes dopamine neuron death in primary human mesencephalic culture. Brain Res. 926: 42-50.
7. XU, J., S.Y. KAO, F.J. LEE, et al. 2002. Dopamine-dependent neurotoxicity of α-synuclein: a mechanism for selective neurodegeneration in Parkinson disease. Nat. Med. 8: 600-606.
8. LOTHARIUS, J. & P. BRUNDIN. 2002. Pathogenesis of Parkinson's disease: dopamine, vesicles and α-synuclein. Nat. Rev. Neurosci. 3: 932-942.
9. LITTLE, K.Y., D.P. MCLAUGHLIN, L. ZHANG, et al. 1998. Brain dopamine transporter messenger RNA and binding sites in cocaine users: a postmortem study. Arch. Gen. Psychiatry 55: 793-799.
10. MASH, D.C., Q. OUYANG, J. PABLO, et al. 2003. Cocaine abusers have an overexpression of α-synuclein in dopamine neurons. J. Neurosci. 23: 2564-2571.
11. UJIKE, H. 2002. Stimulant-induced psychosis and schizophrenia: the role of sensitization. Curr. Psychiatry Rep. 4: 177-184.
12. UJIKE, H., M. HARANO, T. INADA, et al. 2003. Nine- or fewer repeat alleles in VNTR polymorphism of the dopamine transporter gene is a strong risk factor for prolonged methamphetamine psychosis. Pharmacogenomics J. 3: 242-247.
13. AUTERE, J.M., M.J. HILTUNEN, A.J. MANNERMAA, et al. 2002. Molecular genetic analysis of the α-synuclein and the parkin gene in Parkinson's disease in Finland. Eur. J. Neurol. 9: 479-483.
14. SCHNEIDER, S., D. ROESSLI & L. EXCOFFIER. 2000. Arlequin: a software for population genetics data analysis. Ver 2.000. Genetics and Biometry Lab, Department of Anthropology. University of Geneva. Switzerland.
15. SHAM, P.C. & D. CURTIS. 1995. Monte Carlo tests for associations between disease and alleles at highly polymorphic loci. Ann. Hum. Genet. 59: 97-105.
16. LYNCH, W.J., M.E. ROTH & M.E. CARROLL. 2002. Biological basis of sex differences in drug abuse: preclinical and clinical studies. Psychopharmacology (Berl.) 164: 121-137.
17. RICHFIELD, E.K., M.J. THIRUCHELVAM, D.A. CORY-SLECHTA, et al. 2002. Behavioral and neurochemical effects of wild-type and mutated human α-synuclein in transgenic mice. Exp. Neurol. 175: 35-48.
18. VOLKOW, N.D., L. CHANG, G.J. WANG, et al. 2001. Association of dopamine transporter reduction with psychomotor impairment in methamphetamine abusers. Am. J. Psychiatry 158: 377-382.
19. SEKINE, Y., M. IYO, Y. OUCHI, et al. 2001. Methamphetamine-related psychiatric symptoms and reduced brain dopamine transporters studied with PET. Am. J. Psychiatry 158: 1206-1214.