Quorum-sensing control in Staphylococci - A target for antimicrobial drug therapy?

FEMS Microbiology Letters

Volumn 241, Issue 2, 2004, Pages 135-141

  Otto, Michael ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Antibacterial; Biofilm; Infection; Quorum sensing; Staphylococcus

Indexed keywords

BACTERIAL PROTEIN; BACTERIAL RNA; CYTOPLASM PROTEIN; CYTOPLASM PROTEIN TRAP; PEPTIDE; PHEROMONE; RAP PROTEIN; TYROSYLSERYLPROLYLTRYPTOPHYLTHREONYLASPARAGINYLPHENYLALANINE; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; BACTERIAL CELL; BACTERIAL VIRULENCE; BIOFILM; CELL DENSITY; DEVICE INFECTION; DOWN REGULATION; DRUG TARGETING; GENE CONTROL; GENE FUNCTION; GRAM NEGATIVE BACTERIUM; HOSPITAL INFECTION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; PSEUDOMONAS AERUGINOSA; SHORT SURVEY; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BIOFILMS; DRUG DESIGN; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; SIGNAL TRANSDUCTION; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS; VIRULENCE;

BACTERIA (MICROORGANISMS); NEGIBACTERIA; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS;

EID: 10444224621     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.femsle.2004.11.016     Document Type: Short Survey

References (50)

1. L.E. Alksne, and S.J. Projan Bacterial virulence as a target for antimicrobial chemotherapy Curr. Opin. Biotechnol. 11 2000 625 636
2. C. Vuong, and M. Otto Staphylococcus epidermidis infections Microbes. Infect. 4 2002 481 489
3. C. von Eiff, K. Becker, K. Machka, H. Stammer, and G. Peters Nasal carriage as a source of Staphylococcus aureus bacteremia. Study Group N. Engl. J. Med. 344 2001 11 16
4. Anon. (1998). National Nosocomial Surveillance System Report. Center for Disease Control and Prevention, US Department for Health and Human Services, Atlanta, GA
5. F.D. Lowy Staphylococcus aureus infections N. Engl. J. Med. 339 1998 520 532
6. M. Otto Virulence factors of the coagulase-negative staphylococci Front. Biosci. 9 2004 841 863
7. C. Mehlin, C.M. Headley, and S.J. Klebanoff An inflammatory polypeptide complex from Staphylococcus epidermidis: isolation and characterization J. Exp. Med. 189 1999 907 918
8. C. Fuqua, S.C. Winans, and E.P. Greenberg Census and consensus in bacterial ecosystems: the LuxR-LuxI family of quorum-sensing transcriptional regulators Ann. Rev. Microbiol. 50 1996 727 751
9. S. Kjelleberg, and S. Molin Is there a role for quorum sensing signals in bacterial biofilms? Curr. Opin. Microbiol. 5 2002 254 258
10. K.K. Jefferson What drives bacteria to produce a biofilm? FEMS Microbiol. Lett. 236 2004 163 173
11. M. Hentzer, K. Riedel, T.B. Rasmussen, A. Heydorn, J.B. Andersen, M.R. Parsek, S.A. Rice, L. Eberl, S. Molin, N. Hoiby, S. Kjelleberg, and M. Givskov Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound Microbiology 148 2002 87 102
12. M. Hentzer, H. Wu, J.B. Andersen, K. Riedel, T.B. Rasmussen, N. Bagge, N. Kumar, M.A. Schembri, Z. Song, P. Kristoffersen, M. Manefield, J.W. Costerton, S. Molin, L. Eberl, P. Steinberg, S. Kjelleberg, N. Hoiby, and M. Givskov Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors Embo J. 22 2003 3803 3815
13. M. Givskov, R. de Nys, M. Manefield, L. Gram, R. Maximilien, L. Eberl, S. Molin, P.D. Steinberg, and S. Kjelleberg Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling J. Bacteriol. 178 1996 6618 6622
14. M. Manefield, R. de Nys, N. Kumar, R. Read, M. Givskov, P. Steinberg, and S. Kjelleberg Evidence that halogenated furanones from Delisea pulchra inhibit acylated homoserine lactone (AHL)-mediated gene expression by displacing the AHL signal from its receptor protein Microbiology 145 Pt 2 1999 283 291
15. S. Schauder, K. Shokat, M.G. Surette, and B.L. Bassler The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule Mol. Microbiol. 41 2001 463 476
16. M. Kleerebezem, L.E. Quadri, O.P. Kuipers, and W.M. de Vos Quorum sensing by peptide pheromones and two-component signal-transduction systems in gram-positive bacteria Mol. Microbiol. 24 1997 895 904
17. D.G. Cvitkovitch, Y.H. Li, and R.P. Ellen Quorum sensing and biofilm formation in Streptococcal infections J. Clin. Invest. 112 2003 1626 1632
18. R.P. Novick Autoinduction and signal transduction in the regulation of staphylococcal virulence Mol. Microbiol. 48 2003 1429 1449
19. P. Mayville, G. Ji, R. Beavis, H. Yang, M. Goger, R.P. Novick, and T.W. Muir Structure-activity analysis of synthetic autoinducing thiolactone peptides from Staphylococcus aureus responsible for virulence Proc. Natl. Acad. Sci. USA 96 1999 1218 1223
20. M. Otto, R. Süssmuth, G. Jung, and F. Götz Structure of the pheromone peptide of the Staphylococcus epidermidis agr system FEBS Lett. 424 1998 89 94
21. S. Jarraud, G.J. Lyon, A.M. Figueiredo, L. Gerard, F. Vandenesch, J. Etienne, T.W. Muir, and R.P. Novick Exfoliatin-producing strains define a fourth agr specificity group in Staphylococcus aureus J. Bacteriol. 182 2000 6517 6522
22. A.B. Carmody, and M. Otto Specificity grouping of the accessory gene regulator quorum-sensing system of Staphylococcus epidermidis is linked to infection Arch. Microbiol. 181 2004 250 253
23. M. Otto, H. Echner, W. Voelter, and F. Götz Pheromone cross-inhibition between Staphylococcus aureus and Staphylococcus epidermidis Infect. Immun. 69 2001 1957 1960
24. G. Ji, R. Beavis, and R.P. Novick Bacterial interference caused by autoinducing peptide variants Science 276 1997 2027 2030
25. R.P. Novick, S.J. Projan, J. Kornblum, H.F. Ross, G. Ji, B. Kreiswirth, F. Vandenesch, and S. Moghazeh The agr P2 operon: an autocatalytic sensory transduction system in Staphylococcus aureus Mol. Gen. Genet. 248 1995 446 458
26. C. Bunce, L. Wheeler, G. Reed, J. Musser, and N. Barg Murine model of cutaneous infection with gram-positive cocci Infect. Immun. 60 1992 2636 2640
27. A.L. Cheung, K.J. Eberhardt, E. Chung, M.R. Yeaman, P.M. Sullam, M. Ramos, and A.S. Bayer Diminished virulence of a sar-/agr-mutant of Staphylococcus aureus in the rabbit model of endocarditis J. Clin. Invest. 94 1994 1815 1822
28. C. Vuong, F. Götz, and M. Otto Construction and characterization of an agr deletion mutant of Staphylococcus epidermidis Infect. Immun. 68 2000 1048 1053
29. A.M. Hajjar, D.S. O'Mahony, A. Ozinsky, D.M. Underhill, A. Aderem, S.J. Klebanoff, and C.B. Wilson Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin J. Immunol. 166 2001 15 19
30. W.C. Liles, A.R. Thomsen, D.S. O'Mahony, and S.J. Klebanoff Stimulation of human neutrophils and monocytes by staphylococcal phenol-soluble modulin J. Leukoc. Biol. 70 2001 96 102
31. C. Vuong, M. Dürr, A.B. Carmody, A. Peschel, S.J. Klebanoff, and M. Otto Regulated expression of pathogen-associated molecular pattern molecules in Staphylococcus epidermidis: quorum-sensing determines pro-inflammatory capacity and production of phenol-soluble modulins Cell. Microbiol. 6 2004 753 759
32. J.M. Yarwood, and P.M. Schlievert Quorum sensing in Staphylococcus infections J. Clin. Invest. 112 2003 1620 1625
33. C. Vuong, H.L. Saenz, F. Götz, and M. Otto Impact of the agr quorum-sensing system on adherence to polystyrene in Staphylococcus aureus J. Infect. Dis. 182 2000 1688 1693
34. V.G. Fowler Jr., G. Sakoulas, L.M. McIntyre, V.G. Meka, R.D. Arbeit, C.H. Cabell, M.E. Stryjewski, G.M. Eliopoulos, L.B. Reller, G.R. Corey, T. Jones, N. Lucindo, M.R. Yeaman, and A.S. Bayer Persistent bacteremia due to methicillin-resistant Staphylococcus aureus infection is associated with agr dysfunction and low-level in vitro resistance to thrombin-induced platelet microbicidal protein J. Infect. Dis. 190 2004 1140 1149
35. J.M. Yarwood, J.K. McCormick, M.L. Paustian, V. Kapur, and P.M. Schlievert Repression of the Staphylococcus aureus accessory gene regulator in serum and in vivo J. Bacteriol. 184 2002 1095 1101
36. C. Goerke, U. Fluckiger, A. Steinhuber, W. Zimmerli, and C. Wolz Impact of the regulatory loci agr, sarA and sae of Staphylococcus aureus on the induction of alpha-toxin during device-related infection resolved by direct quantitative transcript analysis Mol. Microbiol. 40 2001 1439 1447
37. C. Goerke, S. Campana, M.G. Bayer, G. Doring, K. Botzenhart, and C. Wolz Direct quantitative transcript analysis of the agr regulon of Staphylococcus aureus during human infection in comparison to the expression profile in vitro Infect. Immun. 68 2000 1304 1311
38. C. Vuong, S. Kocianova, Y. Yao, A.B. Carmody, and M. Otto Increased colonization of indwelling medical devices by quorum-sensing mutants of Staphylococcus epidermidis in vivo J. Infect. Dis. 190 2004 1498 1505
39. C. Vuong, C. Gerke, G.A. Somerville, E.R. Fischer, and M. Otto Quorum-sensing control of biofilm factors in Staphylococcus epidermidis J. Infect. Dis. 188 2003 706 718
40. G.J. Lyon, and R.P. Novick Peptide signaling in Staphylococcus aureus and other gram-positive bacteria Peptides 25 2004 1389 1403
41. N. Balaban, and R.P. Novick Autocrine regulation of toxin synthesis by Staphylococcus aureus Proc. Natl. Acad. Sci. USA 92 1995 1619 1623
42. R.P. Novick, H.F. Ross, A.M. Figueiredo, G. Abramochkin, and T.W. Muir Activation and inhibition of the staphylococcal agr system Science 287 2000 391a
43. M. Korem, A.S. Sheoran, Y. Gov, S. Tzipori, I. Borovok, and N. Balaban Characterization of RAP, a quorum sensing activator of Staphylococcus aureus FEMS Microbiol. Lett. 223 2003 167 175
44. N. Balaban, T. Goldkorn, Y. Gov, M. Hirshberg, N. Koyfman, H.R. Matthews, R.T. Nhan, B. Singh, and O. Uziel Regulation of Staphylococcus aureus pathogenesis via target of RNAIII-activating protein (TRAP) J. Biol. Chem. 276 2001 2658 2667
45. N. Balaban, T. Goldkorn, R.T. Nhan, L.B. Dang, S. Scott, R.M. Ridgley, A. Rasooly, S.C. Wright, J.W. Larrick, R. Rasooly, and J.R. Carlson Autoinducer of virulence as a target for vaccine and therapy against Staphylococcus aureus Science 280 1998 438 440
46. Y. Gov, A. Bitler, G. Dell'Acqua, J.V. Torres, and N. Balaban RNAIII inhibiting peptide (RIP), a global inhibitor of Staphylococcus aureus pathogenesis: structure and function analysis Peptides 22 2001 1609 1620
47. N. Balaban, A. Giacometti, O. Cirioni, Y. Gov, R. Ghiselli, F. Mocchegiani, C. Viticchi, M.S. Del Prete, V. Saba, G. Scalise, and G. Dell'Acqua Use of the quorum-sensing inhibitor RNAIII-inhibiting peptide to prevent biofilm formation in vivo by drug-resistant Staphylococcus epidermidis J. Infect. Dis. 187 2003 625 630
48. A. Giacometti, O. Cirioni, Y. Gov, R. Ghiselli, M.S. Del Prete, F. Mocchegiani, V. Saba, F. Orlando, G. Scalise, N. Balaban, and G. Dell'Acqua RNA III inhibiting peptide inhibits in vivo biofilm formation by drug-resistant Staphylococcus aureus Antimicrob. Agents Chemother. 47 2003 1979 1983
49. G. Dell'Acqua, A. Giacometti, O. Cirioni, R. Ghiselli, V. Saba, G. Scalise, Y. Gov, and N. Balaban Suppression of drug-resistant Staphylococcal Infections by the quorum-sensing inhibitor RNAIII-inhibiting peptide J. Infect. Dis. 190 2004 318 320
50. K. Vacheethasanee, and R.E. Marchant Surfactant polymers designed to suppress bacterial (Staphylococcus epidermidis) adhesion on biomaterials J. Biomed. Mater. Res. 50 2000 302 312