Mutation and amplification of RIT1 gene in hepatocellular carcinoma

Chinese Journal of Medical Genetics

Volumn 21, Issue 1, 2004, Pages 43-46

  Li, Jin Tian ^a   Liu, Wei ^a   Kuang, Zhi He ^a   Zhang, Ru Hua ^a   Chen, Han Kui ^a   Feng, Qi Sheng ^a  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

Author keywords

Gene amplification; Gene mutation; Hepatocellular carcinoma; RIT1 gene

Indexed keywords

GLUTAMIC ACID; GLUTAMINE; GUANOSINE TRIPHOSPHATE; NUCLEOTIDE;

5' UNTRANSLATED REGION; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CLINICAL ARTICLE; CONTROLLED STUDY; EXON; FEMALE; FLUORESCENCE; GENE; GENE ACTIVATION; GENE AMPLIFICATION; GENE FREQUENCY; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN TISSUE; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MALE; NUCLEIC ACID BASE SUBSTITUTION; POINT MUTATION; POLYMERASE CHAIN REACTION; QUANTITATIVE ANALYSIS; RIT1 GENE; START CODON;

ADULT; AGED; BASE SEQUENCE; CARCINOMA, HEPATOCELLULAR; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; FEMALE; GENE AMPLIFICATION; HUMANS; LIVER NEOPLASMS; MIDDLE AGED; MUTATION; POINT MUTATION; RAS PROTEINS;

EID: 1042276891     PISSN: 10039406     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Li LD, Lu FZ, Zhang SW, et al. Analyses of tendency in the past 20 years and forecast in the near future on the mortality of the patients with malignant tumors in China. Chin J Oncol, 1997, 19: 3-9.
2. Kusano N, Shiraishi K, Kubo K, et al. Genetic aberrations detected by comparative genomic hybridization in hepatocellular carcinomas: their relationship to clinicopathological features. Hepatology, 1999,29:1858-1862.
3. Marchio A, Pineau P, Meddeb M, et al. Distinct chromosomal abnormality pattern in primary liver cancer of non-B, non-C patients. Oncogene, 2000,19:3733-3738.
4. Wong N, Lai P, Lee SW, et al. Assessment of genetic changes in hepatocellular carcinoma by comparative genomic hybridization analysis: relationship to disease stage, tumor size, and cirrhosis. Am J Pathol, 1999,154:37-43.
5. Guan XY, Fang Y, Sham JS, et al. Recurrent chromosome alterations in hepatocellular carcinoma detected by comparative genomic hybridization. Genes Chromosomes Cancer, 2000, 29: 110-116.
6. Shao H, Kadono-Okuda K, Finlin BS, et al. Biochemical characterization of the Ras-related GTPases Rit and Rin. Arch Biochem Biophys, 1999,371:207-219.
7. LU YY. Oncogenes. In, Zeng YX. eds. Oncology. 2nd ed. Beijing:People Health Publication, 2003.79.
8. Sakabe K, Teramoto H, Zohar M, et al. Potent transforming activity of the small GTP-binding protein Rit in NIH 3T3 cells: evidence for a role of a p38 gamma-dependent signaling pathway. FEBS Lett, 2002,511:15-20.
9. Rusyn EV, Reynolds ER, Shao H, et al. Rit, a non-lipid-modified Ras-related protein, transforms NIH3T3 cells without activating the ERK, JNK, p38 MAPK or PI3K/Akt pathways. Oncogene, 2000, 19:4685-4694.