Characterization of mexiletine as an antagonist of β-adrenoceptor in Chinese hamster ovary cells expressing cloned human β-adrenoceptors

Biochemical Pharmacology

Volumn 67, Issue 5, 2004, Pages 815-822

  Sakamoto, Kenji ^a   Karikomi, Yuiko ^a   Kubota, Yuko ^a   Nakahara, Tsutomu ^a   Ishii, Kunio ^a  

^a KITASATO UNIVERSITY   (Japan)

Author keywords

Adenosine 3 ,5 cyclic monophosphate; Class Ib antiarrhythmic drug; G protein coupled receptor; Lidocaine; Mexiletine; Adrenoceptor

Indexed keywords

ANTIARRHYTHMIC AGENT; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CYANOPINDOLOL I 125; CYCLIC AMP; FORSKOLIN; ISOPRENALINE; LIDOCAINE; MEXILETINE; RADIOLIGAND;

ANIMAL CELL; ARTICLE; CHO CELL; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; HUMAN; LIGAND BINDING; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING;

EID: 1042275541     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2003.09.044     Document Type: Article

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