Protective effect of Emblica officinalis ethanolic extract against 7,12-dimethylbenz(a)anthracene (DMBA) induced genotoxicity in Swiss albino mice

Human and Experimental Toxicology

Volumn 23, Issue 11, 2004, Pages 527-531

  Banu, S Mumtaz ^a   Selvendiran, K ^a   Singh, J Prince Vijeya ^a   Sakthisekaran, D ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

7,12 dimethylbenz(a)anthracene; Emblica officinalis; Genotoxicity; Micronucleus assay; Protective effect

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; ANTIOXIDANT; CARCINOGEN; CYTOCHROME B5; CYTOCHROME P450; EMBLICA OFFICINALIS EXTRACT; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; LIVER ENZYME;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BONE MARROW; CHEMICAL ANALYSIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; EMBLICA OFFICINALIS; ENZYME ACTIVATION; FRUIT; GENOTOXICITY; MALE; MICRONUCLEUS; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ADMINISTRATION, ORAL; ANIMALS; ANTIMUTAGENIC AGENTS; BONE MARROW CELLS; CYTOCHROME P-450 ENZYME SYSTEM; CYTOCHROMES B5; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; LIVER; MALE; MICE; MICRONUCLEUS TESTS; MUTAGENS; PHYLLANTHUS EMBLICA; PLANT EXTRACTS;

ANIMALIA; PHYLLANTHUS EMBLICA; RODENTIA;

EID: 10344263362     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1191/0960327104ht484oa     Document Type: Article

References (29)

1. Gogate VM. Ayurvedic Maieria Medica 1st edn. Bombay: Bombay Continental Prakashan, 1982; 247-48.
2. Rao TS, Kumari KK, Netaji B, Subhokta JP. A pilot study of Svetaprada (leucorrhoea with amalaka guggulu). Journal of Research in Ayurveda and Siddha 1986; 6: 213.
3. Dhir H, Roy AK, Sharma A, Talukder G. Modification of clastogenicity of lead and aluminium in mouse bone marrow cells by dietary ingestion of Phyllanthus emblica fruit extract. Mutation Research 1990; 241: 305-12.
4. Dhir H, Roy AK, Sharma A, Talukder G. Protection afforded by aqueous extracts of Phyllanthus species against cytotoxicity induced by lead and aluminium salts. Phytotherapy Research 1990; 4: 172-76.
5. Nandi P, Talukder G, Sharma A. Dietary chemoprevention of clastogenic effects of 3,4-benzo(a)pyrene by Emblica officinalis Gaertn. fruit extract. British Journal of Cancer 1997; 76: 1279-83.
6. Haque R, Bin-Hafeez B, Ahmad I, Parvez S, Pandey S, Raisuddin S. Protective effects of Emblica officinalis Gaertn., in cyclophosphamide treated mice. Human & Experimental Toxicology 2001; 20: 643-50.
7. Sharma N, Trikha P, Athar M, Raisuddin S. Inhibitory effect of Emblica officinalis on the in vivo clastogenicity of benzo(a)pyrene and cyclophosphamide in mice. Human & Experimental Toxicology 2000; 19: 377-84.
8. Jeena KJ, Joy KL, Kuttan R. Effect of Emblica officinalis, Phyllanthus amarus and Picrorrhiza kurroa on N-nitrosodiethylamine induced hepatocarcinogenesis. Cancer Letters 1999; 136: 11-16.
9. Jeena KJ, Kuttan G, George J, Kuttan R. Antimutagenic and anticarcinogenic activity of Emblica officinalis Gaertn. Journal of Clinical Biochemistry and Nutrition 1996; 22: 171-76.
10. Heddle JA. A rapid in vivo test for chromosomal damage. Mutation Research 1973; 18: 187-90.
11. Hall M, Grover PL. Polycyclic aromatic hydrocarbons metabolism, activation and tumor initiation. In Cooper CS, Grover PL eds. Handbook of experimental pharmacology. New York: Springer-Verlag, 1990, 94/1: 327-72.
12. Schmid W. The micronucleus test. Mutation Research 1975; 31: 9-15.
13. 2+ with endoplasmic reticulum of rat liver. A standardized procedure for the isolation of rat liver microsomes. Analytical Biochemistry 1972; 48: 53-61.
14. Omura T, Sato R. The carbon monoxide binding pigment of liver microsomes. Evidence for its hemoprotein nature. Journal of Biological Chemistry 1964; 239: 2370-78.
15. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 1951; 193: 265-70.
16. Moron MS, Depierre JW, Mannervik B. Levels of glutathione, glutathione reductase and glutathione-S-transferase activities in rat lung and liver. Biochimica et Biophysica Acta 1979; 582: 67-68.
17. Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG. Selenium: biochemical role as a component of glutathione peroxidase. Science 1973; 179: 588-90.
18. Staal GEJ, Visser J, Veeger C. Purification and properties of glutathione reductase of human erythrocytes, Biochimica et Biophysica Acta 1969; 185: 39-48.
19. Habig WH, Pabst MJ, Jokoby WB. Glutathione-S-transferase. The first enzymatic step in mercapturic acid formation. Journal of Biological Chemistry 1974; 249: 7130-39.
20. Jeena KJ, Kuttan G, George J, Kuttan R. Antimutagenic and anticarcinogenic activity of Emblica officinalis Gaertn. Journal of Clinical Biochemistry and Nutrition 1996; 22: 171-76.
21. Jeena KJ, Girija Kuttan, Ramadasan Kuttan. Antitumor activity of Emblica officinalis. Journal of Ethnopharmacology 2001; 75: 65-69.
22. Armen KN, Victor AK. The comparative mutagenic action of 7,12-dimehtylbenz(a)anthracene in the Armenian hamsters and mice. Archive of Oncology 2001; 9: 193-94.
23. Whitehead FW, San RHC, Stich HF. An intestinal cell-mediated chromosome aberration test for the detection of genotoxic agents. Mutation Research 1983; 111: 209-17.
24. Raunio H, Husgaliel-Porsianen K, Anttila S. Diagnosis of polymorphism in carcinogen activating and inactivating enzymes and cancer susceptibility. Gene 1995; 1: 113-20.
25. Wattenberg, LW. Chemoprevention of cancer. Cancer Res 1985; 45: 1-8.
26. Sparnins VL, Venegas PL, Wattenberg LW. Glutathione-S-transferase activity by compounds inhibiting chemical carcinogenesis and by dietary constituents. J Natl Cancer Inst 1982; 68; 493-96.
27. Fujiki H, Yoshizawa S, Horiuchi T, Suganama M, Yatsunami J, Nishiwaki S, Okabe S, Nishi-Waki-Matsushima R, Okuda T, Sugimura T. Anticarcinogenic effects of (-)-epigallocatechin gallate. Prev Med 1992; 21: 503-509.
28. Sayer JM, Yagi H, Wood AW, Conney AH, Jerina DM. Extemely facile reaction between the ultimate carcinogen benzo(a)pyrene 7,8-diol-9,10-epoxide and ellagic acid. J Am Chem Soc 1993; 104: 5562-64.
29. 450 enzymes as targets for chemoprevention against chemical carcinogenesis and toxicity; opportunities and limitations. Cancer Research 1994; 54: 1982-86.