Sequence variation in the SRC gene product affects metastasis formation: The central, but not exclusive, role of the tumor immune response

International Journal of Cancer

Volumn 68, Issue 2, 1996, Pages 228-231

  Taylor Jr , Robert L ^a   England, James M ^b   Kopen, Gene C ^b   Christou, Alexander A ^b   Halpern, Michael S ^b  

^a UNIVERSITY OF NEW HAMPSHIRE   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; TUMOR ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHICKEN; CONTROLLED STUDY; METASTASIS POTENTIAL; NONHUMAN; ONCOGENE SRC; PRIORITY JOURNAL; TUMOR IMMUNITY;

ANIMALS; CHICKENS; EPITOPES; GENES, SRC; NEOPLASM METASTASIS; NEOPLASMS, EXPERIMENTAL; PROTO-ONCOGENE PROTEINS PP60(C-SRC); SPECIES SPECIFICITY;

EID: 10344259602     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19961009)68:2<228::AID-IJC15>3.0.CO;2-6     Document Type: Article

References (11)

1. GELMAN, I.H. and HANAFUSA, H., src-specific immune regression of Rous sarcoma virus-induced tumors. Cancer Res., 53, 915-920 (1993).
2. HALPERN, M.S., ENGLAND, J.M., COATES, L., STOLTZFUS, C.M. and MASON, W.S., Regression of v-src DNA-induced sarcomas is under host genetic control. Virology, 180, 850-860 (1991).
3. HALPERN, M.S., ENGLAND, J.M., KOPEN, G.C., CHRISTOU, A.A. and TAYLOR, R.L., JR., Endogenous c-src as a determinant of the tumorigenicity of src oncogenes. Proc. nat. Acad, Sci. (Wash.), 93, 824-827 (1996).
4. HALPERN, M.S., WISNER, T.W., BROWN, I.P. and ENGLAND, J.M., Immune-based resistance to the formation of v-src-induced distal tumors. Virology, 197, 480-484 (1993).
5. c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation. Cell, 49, 65-73 (1987).
6. PLACHÝ, J., HALA, K., HEJNAR, J., GERYK, J. and SVOBODA, J., src-specific immunity in inbred chickens bearing v-src DNA- and RSV-induced tumors. Immunogenetics, 40, 257-265 (1994).
7. SVOBODA, J., PLACHÝ, J., HEJNAR, J., KARAKOZ, I., GUNTAKA, R.V. and GERYK, J., Tumor induction by LTR, v-src, LTR DNA in four B (MHC) congenic lines of chickens. Immunogenetics, 35, 309-315 (1992).
8. TATOSYAN, A., YATSULA, B., SHTUTMAN, M., MOINOVA, E., KAVERINA, I., MUSATKINA, E., LESKOV, K., MIZENINA, I., ZUEVA, E., CALOTHY, G. and DEZELEE, P., Two novel variants of the v-src oncogene isolated from low and high metastatic RSV-transformed hamster cells. Virology, 216, 347-356 (1996).
9. TAYLOR, R.L., JR., ENGLAND, J.M., KOPEN, G.C., CHRISTOU, A.A. and HALPERN, M.S., Major histocompatibility (B) complex control of the formation of v-src-induced metastases. Virology, 205, 569-573 (1994).
10. TAYLOR, R.L., JR., EWERT, D.L., ENGLAND, J.M. and HALPERN, M.S., Major histocompatibility (R) complex control of the growth pattern of v-src DNA-induced primary tumors. Virology, 191, 477-479 (1992).
11. WISNER, T.W., ENGLAND, J.M., PAN, D., STOKER, A.W. and HALPERN, M.S., Tumor immunity generated in the course of regression of v-src-induced sarcomas. J. Virol., 65, 7020-7024 (1991).