Choriocarcinoma involving the pancreas as first manifestation of a metastatic regressing mixed testicular germ cell tumor

Modern Pathology

Volumn 17, Issue 12, 2004, Pages 1573-1580

  Wang, Lan ^a   Pitman, Martha B ^a   Fernandez Del Castillo, Carlos ^a   Dal Cin, Paula ^b   Oliva, Esther ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Choriocarcinoma; Germ cell tumor; Metastatic malignancy; Pancreas; Regressing; Testis

Indexed keywords

ABDOMINAL PAIN; ADULT; ARTICLE; CANCER INVASION; CASE REPORT; CHORIOCARCINOMA; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; CYTOTROPHOBLAST; DIAGNOSTIC ACCURACY; ECHOGRAPHY; EPIDIDYMITIS; FROZEN SECTION; GERM CELL TUMOR; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; JAUNDICE; MALE; METASTASIS; MIXED TESTICULAR GERM CELL TUMOR; MONONUCLEAR CELL; PANCREAS CARCINOMA; PANCREAS CHORIOCARCINOMA; PANCREATICODUODENECTOMY; PRIORITY JOURNAL; RECURRENT DISEASE; SEMINOMA; SYNCYTIOTROPHOBLAST; TESTIS TERATOMA; TESTIS TUMOR; TREATMENT OUTCOME; TUMOR BLEEDING; TUMOR NECROSIS; WEIGHT REDUCTION;

BIOLOGICAL MARKERS; CHORIOCARCINOMA; CHORIONIC GONADOTROPIN; GERMINOMA; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; KERATINS; MALE; MIDDLE AGED; NEOPLASM REGRESSION, SPONTANEOUS; PANCREAS; PANCREATIC NEOPLASMS; TESTICULAR NEOPLASMS; TESTIS;

EID: 10344256677     PISSN: 08933952     EISSN: None     Source Type: Journal    
DOI: 10.1038/modpathol.3800226     Document Type: Article

References (47)

1. Saigo PE, Brigati DJ, Sternberg SS, et al. Primary gastric choriocarcinoma. An immunohistological study. Am J Surg Pathol 1981;5:333-342.
2. Matthews TH, Heaton GE, Christopherson WM. Primary duodenal choriocarcinoma. Arch Pathol Lab Med 1986;110:550-552.
3. Harada N, Misawa T, Chijiiwa Y, et al. A case of extragenital choriocarcinoma in the jejunum. Am J Gastroenterol 1991;86:1077-1079.
4. Brunner J, Hogberg T, Malmstrom H, et al. Postmenopausal extragenital choriocarcinoma. A case report and review of the literature. Eur J Gynaecol Oncol 1991;12:395-398.
5. Bjornsson J, Scheithauer BW, Leech RW. Primary intracranial choriocarcinoma: a case report. Clin Neuropathol 1986;5:242-245.
6. Childs CC, Korsten MA, Choi HS, et al. Pancreatic choriocarcinoma presenting as inflammatory pseudocyst. Gastroenterology 1985;89:426-431.
7. Zamboni G, Boneti F, Castelli P, et al. Mucinous cystic tumor of the pancreas recurring after 11 years as cystadenocarcinoma with foci of choriocarcinoma and osteoclast-like giant cell tumor. Surg Pathol 1994;5:253-262.
8. Coskun M, Agildere AM, Boyvat F, et al. Primar choriocarcinoma of the stomach and pancreas: CT findings. Eur J Radiol 1998;8:1425-1428.
9. Gonzalez Garcia M, Aldrete JS. Cystic neoplasms of the pancreas: report of 3 cases presenting diagnostic difficulties. Rev Invest Clin 1995;47:43-48.
10. Tinkle LL, Graham BS, Spillane TJ, et al. Testicular choriocarcinoma metastatic to the skin: an additional case and literature review. Cutis 2001;67:117-120.
11. Bettio D, Giardiano D, Rizzi N, et al. Cytogenetic abnormalities detected by direct analysis in a case of choriocarcinoma. Cancer Genet Cytogenet 1993;68:149-151.
12. Jacobsen GK, Barlebo H, Olsen J. Testicular germ cell tumours in Denmark 1976-1980. Pathology of 1058 consecutive cases. Acta Radiol Oncol 1984;23:239-247.
13. Ulbright TM, Mahal BA, Young RH. Tumors of the testis, adnexa, spermatic cord, and scrotum. In: Rosai J (ed). Atlas of Tumor Pathology. Armed Forces Institute of Pathology: Washington, DC: 1999.
14. Klöppel G, Hruban R, Longnecker DS, et al. Tumours of the exocrine pancreas. In: Hamilton SR, Aaltonen LA (eds). WHO Classification of Tumours-Pathology and Genetics of Tumours of the Digestive System. IARC Press: Lyon, 2000, pp 219-252.
15. Gold EB, Goldin SB. Epidemiology of and risk factors for pancreatic cancer. Surg Oncol Clin N Am 1998;7:67-91.
16. Warshaw AL, Fernández-Del Castillo C. Pancreatic carcinoma. N Engl J Med 1992;326:455-465.
17. Wiersema MJ, Vilmann P, Giovannini M, et al. Endosonography-guided fine-needle aspiration biopsy: Diagnostic accuracy and complication assessment. Gastroenterology 1997;112:1087-1095.
18. Cahn M, Chang K, Nguyen P, et al. Impact of endoscopic ultrasound with fine-needle aspiration on the surgical management of pancreatic cancer. Am J Surg 1996;172:470-472.
19. Chang KJ, Nguyen P, Erickson RA, et al. The clinical utility of endoscopic ultrasound-guided fine-needle aspiration in the diagnosis and staging of pancreatic carcinoma. Gastrointest Endosc 1997;45:387-393.
20. Williams DB, Sahai AV, Aabakken L, et al. Endoscopic ultrasound guided fine needle aspiration biopsy: a large single centre experience. Gut 1999;44:720-726.
21. Brugge WR. Endoscopic ultrasound-guided pancreatic fine-needle aspiration: a review. Techn Gastrointest Endosc 2000;2:149-154.
22. Silverman JF, Dabbs DJ, Finley JL, et al. Fine-needle aspiration biopsy of pleomorphic (giant cell) carcinoma of the pancreas. Cytologic, immunocytochemical, and ultrastructural findings. Am J Clin Pathol 1988;89:714-720.
23. Pinto MM, Monteiro NL, Tizol DM. Fine needle aspiration of pleomorphic giant-cell carcinoma of the pancreas. Case report with ultrastructural observations. Acta Cytol 1986;30:430-434.
24. Mullick SS, Mody DR. Osteoclastic giant cell carcinoma of the pancreas. Report of a case with aspiration cytology. Acta Cytol 1996;40:975-979.
25. Chao TY, Nieb S, Huang SH, et al. Cytology of fine needle aspirates of primary extragonadal germ cell tumors. Acta Cytol 1997;41:497-503.
26. Louhimo J, Nordling S, Alfthan H, et al. Specific staining of human chorionic gonadotropin beta in benign and malignant gastrointestinal tissues with monoclonal antibodies. Histopathology 2001;38:418-424.
27. Ishikawa H, Tsutsumi HMI, Yoshida H, et al. Undifferentiated carcinoma of the pancreas with choriocarcinomatous feature producing human chorionic gtonadotropin. Can No Rinsho 1986;32:1041-1045.
28. Syrigos KN, Fyssas J, Konstandoulakis MM, et al. Beta human choionic gonadotropin concentration in serum of patients with pancreatic adenocarcinoma. Gut 1998;42:88-91.
29. Mori H, Soeda O, Kamano K, et al. Choriocarcinomatous change with immunohistochemically HCG-positive cells in the gastric carcinoma of the males. Virch Arch 1982;396:141-153.
30. Ikura Y, Inoue T, Tsukuda H, et al. Primary choriocarcinoma and human chorionic gonadotropin-producing giant cell carcinoma of the lung: are they independent entities? Histopathology 2000;36:17-25.
31. Nguyen GK. Adenocarcinoma of the sigmoid colon with focal choriocarcinoma metaplasia: a case report. Dis Colon Rectum 1982;25:230-234.
32. Zettl A, Konard MA, Polzin S, et al. Urothelial carcinoma of the renal pelvis with choriocarcinomatous features: genetic evidence of clonal evolution. Hum Pathol 2002;33:1234-1237.
33. Grammatico D, Grignon DJ, Eberwein P, et al. Transitional cell carcinoma of the renal pelvis with choriocarcinomatous differentiation: immunohistochemical and immunoelectron microscopic assessment of human chorionic gonadotropin production by transitional cell carcinoma of the urinary bladder. Cancer 1993;71:1835-1841.
34. Savage J, Subby W, Okagaki T. Adenocarcinoma of the endometrium with trophoblastic differentiation and metastases as choriocarcinoma: a case report. Gynecol Oncol 1987;26:257-262.
35. Oliva E, Andrada E, Pezzica E, et al. Ovarian carcinomas with choriocarcinomatous differentiation. Cancer 1993;72:2441-2446.
36. Hainsworth JD, Greco FA. Extragonadal germ cell tumors and unrecognized germ cell tumors. Semin Oncol 1992;19:119-127.
37. Fine G, Smith RW, Pachter MR. Primary extragenital choriocarcinoma in the male subject. Am J Med 1962;32:776-794.
38. Sullivan LG. Primary choriocarcinoma of the lung in a man. Arch Pathol Lab Med 1989;113:82-83.
39. Bohle A, Studer UE, Sonntag RW, et al. Primary or secondary extragonadal germ cell tumors? J Urol 1986;135:939-943.
40. Hanna NH, Ulbright TM, Einhorn LH. Primary choriocarcinoma of the bladder with the detection of isochromosome 12p. J Urol 2002;167:1781.
41. Ahmed MN, Kim K, Haddad B, et al. Comparative genomic hybridization studies in hydatidiform moles and choriocarcinoma: amplification of 7q21-q31 and loss of 8p12-q21 in choriocarcinoma. Cancer Genet Cytogenet 2000;116:10-15.
42. Rottinto A, DeBellis H. Extragenital chorioma: its relation to teratoid vestiges in the testicles. Arch Pathol 1944;37:78-80.
43. Azzopardi JG, Mostofi FK, Theiss EA. Lesions of the testes observed in certain patients with widespread choriocarcinoma and related tumors. Am J Pathol 1961;38:207-225.
44. Lopez JI, Angulo JC. Burned-out tumour of the testis presenting as retroperitoneal choriocarcinoma. Int Urol Nephrol 1994;26:549-553.
45. Bar W, Hedinger C. Comparison of histologic types of primary testicular germ cell tumors with their metastases: consequences for the WHO and the British nomenclatures? Virch Arch 1976;370:41-54.
46. Crook JC. Morphogenesis of testicular tumours. J Clin Pathol 1968;21:71-74.
47. Medina-Franco H, Helpern NB, Aldrete JS. Pancreaticoduodenectomy for metastatic tumors to the periampullary region. J Gastrointest Surg 1999;3:119-122.