Combination chemotherapy of BCNU and didox acts synergystically in 9L glioma cells

Nucleosides, Nucleotides and Nucleic Acids

Volumn 23, Issue 8-9, 2004, Pages 1531-1535

  Horvath, Zsuzsanna ^a   Bauer, Wolfgang ^a   Hoechtl, Thomas ^a   Saiko, Philipp ^a   Fritzer Szekeres, Monika ^a   Tihan, Tarik ^b   Szekeres, Thomas ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

BCNU; Combination chemotherapy; Didox; Glioblastoma multiforme; Ribonucleotide reductase

Indexed keywords

3,4 DIHYDROXYBENZOHYDROXAMIC ACID; CARMUSTINE;

ANIMAL CELL; CANCER COMBINATION CHEMOTHERAPY; CATALYSIS; CLONOGENESIS; CONFERENCE PAPER; CYTOTOXICITY; DNA REPAIR; DRUG POTENTIATION; GENE EXPRESSION; GENE OVEREXPRESSION; GLIOBLASTOMA; GLIOMA; GLIOMA CELL; GROWTH INHIBITION; NONHUMAN; RAT;

ANIMALS; ANTI-INFECTIVE AGENTS, LOCAL; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, ALKYLATING; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BRAIN NEOPLASMS; CARMUSTINE; CELL LINE, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLORING AGENTS; DNA REPAIR; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; GENTIAN VIOLET; GLIOBLASTOMA; GLIOMA; HYDROXAMIC ACIDS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; TIME FACTORS;

ANIMALIA;

EID: 10344242441     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-200027746     Document Type: Conference Paper

References (3)

1. Ali-Osman, F.; Raikar, A.; Young, P. Formation and repair of 1,3-bis(2-chloroethyl)-nitrosourea and cisplatin induced total genomic DNA interstrand crosslinks in human glioma cells. Cancer Biochem. Biophys. 1995, 14, 231-241.
2. Van't Riet, B.; Wampler, G.L.; Elford, H.L. Synthesis of hydroxy amino substituted benzohydroxamic acids: inhibition of ribonucleotide reductase and antitumor activity. J. Med. Chem. 1979, 22, 589-593.
3. Garrett, C.D. A rapid and sensitive high performance liquid chromatography assay for deoxyribonucleotide triphosphates in cell extracts. Anal. Biochem. 1979, 99, 268-273.