X-inactivation is stably maintained in mouse embryos deficient for histone methyl transferase G9a

Genesis (United States)

Volumn 40, Issue 3, 2004, Pages 151-156

  Ohhata, Tatsuya ^a,b   Tachibana, Makoto ^d   Tada, Masako ^d   Tada, Takashi ^d   Sasaki, Hiroyuki ^b,c   Shinkai, Yoichi ^d   Sado, Takashi ^a,b,c  

^a JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^b NATIONAL INSTITUTE OF GENETICS   (Japan)

^c GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

^d KYOTO UNIVERSITY   (Japan)

Author keywords

G9a; Histone methyltransferase; Mouse; X inactivation; Xist

Indexed keywords

EMBRYONIC ECTODERM DEVELOPMENT PROTEIN; HISTONE H3; HISTONE METHYLTRANSFERASE G9A; LYSINE; METHYLTRANSFERASE; PROTEIN; PROTEIN EZH2; PROTEIN PCG; PROTEIN XIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; COVALENT BOND; ECTODERM; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; ENZYME SPECIFICITY; GENE DOSAGE; GENE SILENCING; GENETIC STABILITY; HETEROCHROMATIN; METHYLATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; X CHROMOSOME INACTIVATION;

MAMMALIA;

EID: 10344237024     PISSN: 1526954X     EISSN: None     Source Type: Journal    
DOI: 10.1002/gene.20077     Document Type: Article

References (36)

1. Avner P, Heard E. 2001. X-chromosome inactivation: counting, choice and initiation. Nat Rev Genet 2:59-67.
2. Boggs BA, Cheung P, Heard E, Spector DL, Chinault AC, Allis CD. 2002. Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes. Nat Genet 30:73-76.
3. Brockdorff N. 2002. X-chromosome inactivation: closing in on proteins that bind Xist RNA. Trends Genet 18:352-358.
4. Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, Tempst P, Jones RS, Zhang Y. 2002. Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science 298:1039-1043.
5. Czermin B, Melfi R, McCabe D, Seitz V, Imhof A, Pirrotta V. 2002. Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell 111:185-196.
6. Dodge JE, Kang YK, Beppu H, Lei H, Li E. 2004. Histone H3-K9 methyltransferase ESET is essential for early development. Mol Cell Biol 24:2478-2486.
7. Erhardt S, Su IH, Schneider R, Barton S, Bannister AJ, Perez-Burgos L, Jenuwein T, Kouzarides T, Tarakhovsky A, Surani MA. 2003. Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development. Development 130:4235-4248.
8. Hadjantonakis AK, Cox LL, Tam PP, Nagy A. 2001. An X-linked GFP transgene reveals unexpected paternal X-chromosome activity in trophoblastic giant cells of the mouse placenta, genesis 29:133-140.
9. Heard E, Rougeulle C, Arnaud D, Avner P, Allis CD, Spector DL. 2001. Methylation of histone H3 at Lys-9 is an early mark on the X chromosome during X inactivation. Cell 107:727-738.
10. Kay GF, Penny GD, Patel D, Ashworth A, Brockdorff N, Rastan S. 1993. Expression of Xist during mouse development suggests a role in the initiation of X chromosome inactivation. Cell 72:171-182.
11. Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D. 2002. Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev 16:2893-2905.
12. Lyon MF. 1961. Gene action in the X-chromosome of the mouse (Mus musculus L). Nature 190:372-373.
13. Mak W, Baxter J, Silva J, Newall AE, Otte AP, Brockdorff N. 2002. Mitotically stable association of polycomb group proteins Eed and Enx1 with the inactive X chromosome in trophoblast stem cells. Curr Biol 12:1016-1020.
14. Marahrens Y, Panning B, Dausman J, Strauss W, Jaenisch R. 1997. Xist-deficient mice are defective in dosage compensation but not spermatogenesis. Genes Dev 11:156-166.
15. Mermoud JE, Popova B, Peters AH, Jenuwein T, Brockdorff N. 2002. Histone H3 lysine 9 methylation occurs rapidly at the onset of random X chromosome inactivation. Curr Biol 12:247-251.
16. Müller J, Hart CM, Francis NJ, Vargas ML, Sengupta A, Wild B, Miller EL, O'Connor MB, Kingston RE, Simon JA. 2002. Histone methyltransferase activity of a Drosophila Polycomb group repressor complex. Cell 111:197-208.
17. Nakanishi T, Kuroiwa A, Yamada S, Isotani A, Yamashita A, Tairaka A, Hayashi T, Takagi T, Ikawa M, Matsuda Y, Okabe M. 2002. FISH analysis of 142 EGFP transgene integration sites into the mouse genome. Genomics 80:564-574.
18. O'Carroll D, Erhardt S, Pagani M, Barton SC, Surani MA, Jenuwein T. 2001. The polycomb-group gene Ezh2 is required for early mouse development. Mol Cell Biol 21:4330-4336.
19. Ogawa H, Ishiguro K, Gaubatz S, Livingston DM, Nakatani Y. 2002. A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. Science 296:1132-1136.
20. Penny GD, Kay GF, Sheardown SA, Rastan S, Brockdorff N. 1996. Requirement for Xist in X chromosome inactivation. Nature 379: 131-137.
21. Perez-Burgos L, Peters AH, Opravil S, Kauer M, Mechtler K, Jenuwein T. 2004. Generation and characterization of methyl-lysine histone antibodies. Methods Enzymol 376:234-254.
22. Peters AH, Mermoud JE, O'Carroll D, Pagani M, Schweizer D, Brockdorff N, Jenuwein T. 2002. Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin. Nat Genet 30: 77-80.
23. Peters AH, Kubicek S, Mechtler K, O'Sullivan RJ, Derijck AA, Perez-Burgos L, Kohlmaier A, Opravil S, Tachibana M, Shinkai Y, Martens JH, Jenuwein T. 2003. Partitioning and plasticity of repressive histone methylation states in mammalian chromatin. Mol Cell 12:1577-1589.
24. Plath K, Fang J, Mlynarczyk-Evans SK, Cao R, Worringer KA, Wang H, de la Cruz CC, Otte AP, Panning B, Zhang Y. 2003. Role of histone H3 lysine 27 methylation in X inactivation. Science 300:131-135.
25. Rice JC, Briggs SD, Ueberheide B, Barber CM, Shabanowitz J, Hunt DF, Shinkai Y, Allis CD. 2003. Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains. Mol Cell 12:1591-1598.
26. Sado T, Tada T, Takagi N. 1996. Mosaic methylation of Xist gene before chromosome inactivation in undifferentiated female mouse embryonic stem and embryonic germ cells. Dev Dyn 205:421-434.
27. Sado T, Wang Z, Sasaki H, Li E. 2001. Regulation of imprinted X-chromosome inactivation in mice by Tsix. Development 128:1275-1286.
28. Schotta G, Lachner M, Sarma K, Ebert A, Sengupta R, Reuter G, Reinberg D, Jenuwein T. 2004. A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev 18:1251-1262.
29. Silva J, Mak W, Zvetkova I, Appanah R, Nesterova TB, Webster Z, Peters AH, Jenuwein T, Otte AP, Brockdorff N. 2003. Establishment of histone H3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes. Dev Cell 4:481-495.
30. Tachibana M, Sugimoto K, Fukushima T, Shinkai Y. 2001. Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3. J Biol Chem 276:25309-25317.
31. Tachibana M, Sugimoto K, Nozaki M, Ueda J, Ohta T, Ohki M, Fukuda M, Takeda N, Niida H, Kato H, Shinkai Y. 2002. G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. Genes Dev 16:1779-1791.
32. Takagi N, Sasaki M. 1975. Preferential inactivation of the paternally derived X chromosome in the extraembryonic membranes of the mouse. Nature 256:640-642.
33. Takagi N, Sugimoto M, Yamaguchi S, Ito M, Tan SS, Okabe M. 2002. Nonrandom X chromosome inactivation in mouse embryos carrying Searle's T(X;16)16H translocation visualized using X-linked LACZ and GFP transgenes. Cytogenet Genome Res 99:52-58.
34. Wang J, Mager J, Chen Y, Schneider E, Cross JC, Nagy A, Magnuson T. 2001. Imprinted X inactivation maintained by a mouse Polycomb group gene. Nat Genet 28:371-375.
35. Xin Z, Tachibana M, Guggiari M, Heard E, Shinkai Y, Wagstaff J. 2003. Role of histone methyltransferase G9a in CpG methylation of the Prader-Willi syndrome imprinting center. J Biol Chem 278:14996-15000.
36. Yang L, Xia L, Wu DY, Wang H, Chansky HA, Schubach WH, Hickstein DD, Zhang Y. 2002. Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor. Oncogene 21:148-152.