Genetic determinants of the pre- and post-azathioprine therapy thiopurine methyltransferase activity phenotype

Nucleosides, Nucleotides and Nucleic Acids

Volumn 23, Issue 8-9, 2004, Pages 1403-1405

  Arenas, M ^a   Duley, J A ^a   Ansari, A ^a   Shobowale Bakre, E A ^a   Fairbanks, L ^a   Soon, S Y ^a   Sanderson, J ^a   Marinaki, A M ^a  

^a GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

6MP: 6Mercaptopurine and TPMT: Thiopurine methyltransferase; Aza: Azathioprine; VNTR: Variable number tandem repeats

Indexed keywords

AZATHIOPRINE; THIOPURINE METHYLTRANSFERASE;

CONFERENCE PAPER; DRUG EFFICACY; ENTERITIS; ENZYME ACTIVITY; ENZYME POLYMORPHISM; ERYTHROCYTE; HUMAN; MAJOR CLINICAL STUDY; PREDICTION; VARIABLE NUMBER OF TANDEM REPEAT;

ALLELES; ANTIMETABOLITES; AZATHIOPRINE; ERYTHROCYTES; GENOTYPE; HETEROZYGOTE; HUMANS; METHYLTRANSFERASES; MINISATELLITE REPEATS; OPEN READING FRAMES; PHENOTYPE; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); PURINES; TIME FACTORS; VARIATION (GENETICS);

EID: 10344233202     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-200027643     Document Type: Conference Paper

References (3)

1. Lennard, L. TPMT in the treatment of Crohn's disease with azathioprine. Gut 2002, 57, 143-146.
2. Ansari, A.; Hassan, C.; Duley, J.; Marinaki, A.; Shobowale-Bakre, E.M.; Seed, P.; Meenan, J.; Yim, A.; Sanderson, J. Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease. Aliment. Pharmacol. Ther. 2002, 16, 1743-1750.
3. Marinaki, A.M.; Arenas, M.; Khan, Z.H.; Lewis, C.M.; Shobowale-Bakre el, M.; Escuredo, E.; Fairbanks, L.D.; Mayberry, J.F.; Wicks, A.C.; Ansari, A.; Sanderson, J.; Duley, J.A. Genetic determinants of the thiopurine methyltransferase intermediate activity phenotype in British Asians and Caucasians. Pharmacogenetics 2003, 13, 97-105.