Effect of spirapril and hydrochlorothiazide on platelet function and euglobulin clot lysis time in patients with mild hypertension

Angiology

Volumn 47, Issue 10, 1996, Pages 951-956

  Gleerup, G ^a   Roland Petersen, J ^a   Mehlsen, J ^a   Winther, K ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

HYDROCHLOROTHIAZIDE; SPIRAPRIL;

ADULT; AGED; ANTIHYPERTENSIVE ACTIVITY; ANTIHYPERTENSIVE THERAPY; ARTICLE; BLOOD CLOT LYSIS; CLINICAL ARTICLE; DRUG EFFECT; DRUG EFFICACY; HUMAN; HYPERTENSION; MALE; THROMBOCYTE AGGREGATION;

EID: 10244265937     PISSN: 00033197     EISSN: None     Source Type: Journal    
DOI: 10.1177/000331979604701003     Document Type: Article

References (19)

1. Collin R, Peto R, MacMahon S, et al: Blood pressure, stroke, and coronary heart disease. Part 2, short-term reduction in blood pressure: Overview of randomized drug trials in their epidemilogical context. Lancet 335:827-838, 1990.
2. Medical Research Council Working Party: MRC trial of treatment of mild hypertension: Principal results. Br Med J 291:97-104, 1985.
3. Winther K, Gleerup G, Hedner T: Enhanced risk of thromboembolic disease in hypertension from platelet hyperfunction and decreased fibrinolytic activity: Has antihypertensive therapy any influence? J Cardiovasc Pharmacol 19 (suppl 3):S21-S24, 1992.
4. Winther K, Knudsen JB, Jorgensen EO: Differential effects of timolol and metoprolol on platelet function at rest and during exercise. Eur Heart J 33:587-592, 1988.
5. Winther K, Trap-Jensen J: The effect of three beta-blockers with different pharmacodynamic properties on platelet aggregation, and platelet and plasma cyclic AMP. Eur Clin Pharmacol 35:17-20, 1988.
6. Winther K, Warberg J, Knigge U: The effect of intrinsic sympathomimetic activity on platelet aggregation and fibrinolytic activity . Curr Opin Cardiol 3(2):129-131, 1988.
7. Winther K: The effect of beta-blockade on platelet function and fibrinolytic activity. J Cardiovasc Pharmacol 10:94-98, 1987.
8. The Norwegian Multicenter Study group: Timolol-induced reduction in mortality and reinfarction in patients surviving acute myocardial infarction. N Engl J Med 304:801-807, 1981.
9. Johannessen KA, Nordehaug JE, Von der Lippe G: Increased occurrence of left ventricular thrombi during early treatment with timolol in patients with acute myocardial infarction. Circulation 75:151-155, 1987.
10. Gleerup G, Winther K: Differential effects of non-specific beta-blockade and calcium antagonism on blood-clotting mechanisms. Am J Med 86 (suppl 4A):127-129, 1989.
11. Gleerup G, Winther K: Decreased fibrinolytic activity and increased platelet function in hypertension: Possible influence of calcium antagonism. Am Heart J 4:168-171, 1991.
12. Ding YA, Kenyon CJ, Semple PF: Receptors for angiotensin II on platelets from man, Clin Sci 66:725-731, 1984.
13. Ding YA, Macintyra E, Kenyon CJ: Potentiation of adrenaline induces platelet aggregation by angiotensin II. Thromb Haemost 54:717-720, 1985.
14. Someya N, Morotomi Y, Kodama K: Suppressive effect of captopril on platelet aggregation in essential hypertension. J Cardiovasc Pharmacol 6:840-843, 1984.
15. Birkebaek NH, Vejby-Christensen H, Jakobsen P: The effect of nifedipine and captopril on platelet activation and prostanoid production in essential hypertension. J Hypertens 6 (suppl 4):S378-S380, 1988.
16. Winther K, Trap-Jensen J: The effect of exercise on platelet beta-adrenoceptor function and platelet aggregation in healthy human volunteers. Clin Physiol 8:147-153, 1988.
17. Landin K, Tengborn L, Smith U: Elevated fibrinogen and plasminogen activator inhibitor (PAI-1) in hypertension are related to metabolic risk factors for cardiovascular disease. J Intern Med 227:273-278, 1990.
18. Hamsten A, Wiman B, De Faire U, et al: Increased plasma levels of a rapid inhibitor of tissue plasminogen activator in young survivors of myocardial infarction. N Engl J Med 313:1557-1563, 1985.
19. Gram J, Jespersen J: A selective depression of tissue plasminogen activator (t-PA) activity in euglobulins characterizes a risk group among survivors of acute myocardial infarction. Thromb Haemost 57:137-139, 1987.