Hemoglobin exacerbates the ocular inflammatory response to endotoxin

Graefe's Archive for Clinical and Experimental Ophthalmology

Volumn 234, Issue 10, 1996, Pages 643-647

  Christine McGahan, M ^a   Grimes, Angela M ^a   Fleisher, Lloyd N ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEFEROXAMINE; ENDOTOXIN; FREE RADICAL; HEMOGLOBIN; IRON; PROTEIN; TRANSFERRIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; AQUEOUS HUMOR; ARTICLE; BLEEDING; CELL INFILTRATION; CONTROLLED STUDY; EYE INFLAMMATION; INTRAVITREAL DRUG ADMINISTRATION; IRIDOCYCLITIS; LEUKOCYTE; NONHUMAN; PRIORITY JOURNAL; RABBIT; SLIT LAMP;

EID: 10244255175     PISSN: 0721832X     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf00185299     Document Type: Article

References (18)

1. Benson W, Spalter H (1971) Vitreous hemorrhage: a review of experimental and clinical investigation. Surv Ophthalmol 15: 297-310
2. Benson WE, Wirostko E, Spalter HF (1969) The effects of inflammation on experimentally induced vitreous hemorrhage. Arch Ophthalmol 82: 822-826
3. Burke JM (1981) Vitreal superoxide and superoxide dismutase after hemorrhagic injury: the role of invasive cells. Invest Ophthalmol Vis Sci 20: 435-441
4. Doly M, Bonhomme B, Vennat JC (1986) Experimental study of the retinal toxicity of hemoglobinic iron. Ophthalmic Res 18: 21-27
5. Fleisher LN, Ferrell JB, Olson NC, McGahan MC (1989) Dimethylthiourea inhibits the inflammatory response to intravitreally-injected endotoxin. Exp Eye Res 48: 561-567
6. Hippel E von (1894) Über Siderosis bulbi und die Beziehungen zwischen siderotischer und hämatogener Pigmentierung. Graefes Arch Ophthalmol 40: 123-279
7. Hogan MJ, Kimura SJ, Thygeson P (1950) Signs and symptoms of uveitis. I. Anterior uveitis. Am J Ophthalmol 47: 155-170
8. McGahan MC (1992) Does the lens serve as a "sink" for iron during ocular inflammation? Exp Eye Res 54: 525-530
9. McGahan MC, Fleisher LN (1986) A micromethod for the determination of iron and total iron-binding capacity in intraocular fluids and plasma using electrothermal atomic absorption spectroscopy. Anal Biochem 156: 397-402
10. McGahan MC, Fleisher LN (1988) Inflammation-induced changes in the iron concentration and total iron-binding capacity of the intraocular fluids of rabbits. Graefe's Arch Clin Exp Ophthalmol 226: 27-30
11. McGahan MC, Grimes AM, Fleisher LN (1994) Transferrin inhibits the ocular inflammatory response. Exp Eye Res 58: 509-511
12. McGahan MC, Grimes AM, Nasisse MR Fleisher LN (1995) Iron uptake by cultured lens epithelial cells. Graefe's Arch Clin Exp Ophthalmol 233: 354-359
13. Rao NA, Romero JL, Fernandez MAS, Sevanian A, Marak GE Jr (1986) Effect of iron chelation on severity of ocular inflammation in an animal model. Arch Ophthalmol 104: 1369-1371
14. Regnault FR (1970) Vitreous hemorrhage: an experimental study. I. A macroscopic and isotopic study of the evolution of whole blood and hemoglobin. Arch Ophthalmol 83: 458-474
15. Sadrzadeh SMH, Eaton JW (1988) Hemoglobin-mediated oxidant damage to the central nervous system requires endogenous ascorbate. J Clin Invest 82: 1510-1515
16. Sadrzadeh SMH, Anderson DK, Panter SS, Hallaway PE, Eaton JW (1987) Hemoglobin potentiates central nervous system damage. J Clin Invest 79: 662-664
17. Squire C, McEwen WK (1958) The effect of iron compounds on rabbit vitreous. Am J Ophthalmol 46: 356-358
18. Sullivan SG, Baysal E, Stern A (1992) Inhibition of hemin-induced hemolysis by desferrioxamine: binding of hemin to red cell membranes and the effects of alteration of membrane sulfhydryl groups. Biochim Biophys Acta 1104: 38-44