Endotoxaemia and postoperative hypermetabolism in coronary artery bypass surgery: The role of ketanserin

British Journal of Anaesthesia

Volumn 77, Issue 4, 1996, Pages 473-479

  Oudemans Van Straaten, H M ^a   Jansen, P G M ^b   Te Velthuis, H ^c   Stoutenbeek, Chr P ^d   Zandstra, D F ^a   Van Deventer, S J H ^d   Sturk, A ^e   Wildevuur, Ch R H ^b   Eijsman, L ^b  

^a ONZE LIEVE VROUWE GASTHUIS   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c CENTRAL LABORATORY   (Netherlands)

^d ACADEMIC MEDICAL CENTER   (Netherlands)

^e LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Complications, endotoxaemia; Metabolism, oxygen consumption; Oxygen, consumption; Pharmacology, ketanserin; Surgery, cardiovascular

Indexed keywords

ENDOTOXIN; KETANSERIN; SEROTONIN ANTAGONIST;

ADULT; AGED; ARTICLE; CARDIOVASCULAR DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY BYPASS SURGERY; DRUG EFFICACY; ENDOTOXEMIA; HEART SURGERY; HUMAN; HYPERMETABOLISM; INTRAVENOUS DRUG ADMINISTRATION; MALE; OXYGEN CONSUMPTION; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VENOUS OXYGEN TENSION;

EID: 10244250354     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/77.4.473     Document Type: Article

References (28)

1. Westaby S. Organ dysfunction after cardiopulmonary bypass. A systemic inflammatory reaction by the extracorporeal circuit. Intensive Care Medicine 1987; 13: 89-95
2. Jansen NJG, van Oeveren W, vd Broek L, Oudemans-van Straaten HM, Stoutenbeek CP, Chamg Njoek Joen M, Roozendaal KJ, Eysman L, Wildevuur CRH. Inhibition by dexamethasone of the reperfusion phenomena in cardiopulmonary bypass. Journal of Thoracic and Cardiovascular Surgery 1991; 102: 515-525.
3. Chiara O, Giomarelli PP, Biagioli B, Rosi R, Gattinoni L. Hypermetabolic response after hypothermie cardiopulmonary bypass. Critical Care Medicine 1987; 15: 995-1000.
4. Chenoweth DE, Steven WC, Cooper BA, Hugh TE, Stewart RW, Blackstone EH, Kirklin JW. Complement activation during cardiopulmonary bypass. New England Journal of Medicine 1981; 304: 497-503.
5. Kirklin JK, Westaby S, Blackstone EH, Kirklin JW, Chenoweth DE, Pavifico AD. Complement and the damaging effects of cardiopulmonary bypass. Journal of Thoracic and Cardiovascular Surgery 1983; 86: 845-847.
6. van Oeveren W, Kazatchkine MD, Descamps-Latschka B, Maillet F, Fischer E, Carpentier A, Wildevuur CRH. Deleterious effects of cardiopulmonary bypass. Journal of Thoracic and Cardiovascular Surgery 1985; 89: 888-899.
7. Oudemans-van Straaten HM, Jansen PGM, te Velthuis H, Beenakkers ICM, Stoutenbeek CP, van Deventer SJH, Sturk A, Eijsman L, Wildevuur ChRH. Increased oxygen consumption after cardiac surgery is associated with the inflammatory response to endotoxaemia. Intensive Care Medicine 1996; 22: 294-300.
8. Beutler B, Cerami A. Cachectin: more than a tumor necrosis factor. New England Journal of Medicine 1987; 316: 379-386.
9. Michie HR, Manogue KR, Spriggs DR, Revhaug A, O'Dwyer S, Dinarello ChA, Cerami A, Wolff SM, Wilmore DW. Detection of circulating tumor necrosis factor after endotoxin administration. New England Journal of Medicine 1988; 318: 1481-1486.
10. Fiddian Green RG, Baker S. Predictive value of the stomach wall pH for complications after cardiac operations: comparison with other monitoring. Critical Care Medicine 1987; 15: 153-156.
11. Mythen MG, Webb AR. Intra-operative gut mucosal hypoperfusion is associated with increased post-operative complications and costs. Intensive Care Medicine 1994; 20: 99-104.
12. Anderson L, Landow L, Baek L, Jansen E, Baker S. Association between intramucosal pH and splanchnic endotoxin, antibody to endotoxin and tumor necrosis factor concentrations in patients undergoing cardiopulmonary bypass. Critical Care Medicine 1993; 21: 210-217.
13. Oudemans-van Straaten HM, Jansen PGM, Hoek FJ, van Deventer SJH, Sturk A, Stoutenbeek CP, Tytgat GNJ, Wildevuur ChRH, Eijsman L. Intestinal permeability, circulating endotoxin and post-operative systemic responses in cardiac surgery patients. Journal of Thoracic and Cardiovascular Anesthesia 1996; 10: 187-194.
14. van Reempts J, Borgers M, Xhonneux R, de Clerck F, Awouters F. The inhibition of ischemic lesions of the rat gastric mucosa by a novel serotonin antagonist: a light and electron microscopic study. Angiology 1981; 32: 529-542.
15. Awouters FH, Niemegeers CJ, Janssen PA. A pharmacologic analysis of the rat mast cell 5HT gastric lesion test and the effects of ketanserin. Drug Development Research 1985; 5: 303-312.
16. 2- serotonergic receptors. Journal of Pharmacology and Experimental Therapeutics 1981; 218: 217-230.
17. Vanhoutte PM, Houston DS. Platelets, endothelium and vasospasm. Circulation 1985; 72: 728-734.
18. Jansen, PGM, te Velthuis H, Oudemans-van Straaten HM, Bulder ER, van Deventer SJH, Sturk A, Eijsman L, Wildevuur ChRH. Perfusion-related factors of endotoxin release during cardiopulmonary bypass. European Journal of Cardiothoracic Surgery 1994; 8: 125-129.
19. Sturk A, Janssen ME, Muylaert FR, Joop K, Thomas LLM, ten Cate JW. Detection of bacterial toxins with Limulus amoebocyte lysate test. In: Watson SW, Levin J, Novitsky TJ, eds. Endotoxin Testing in Blood. New York: Alan R. Liss, 1987; 371-385.
20. Novitsky TJ. Limulus amoebocyte lysate (LAL) detection of endotoxin in human blood. Journal of Endotoxin Research 1994; 1: 253-263.
21. Takala J, Keinänen O, Väisänen P, Kari A. Measurement of gas exchange in intensive care: laboratory and clinical validation of a new device. Critical Care Medicine 1989; 17: 1041-1047.
22. Oudemans-van Straaten HM, Scheffer GJ, Wildevuur ChRH, Eysman L. Oxygen consumption after cardiopulmonary bypass. Implications of different measurement methods. Intensive Care Medicine 1993; 19: 105-110.
23. Altman DG. Practical Statistics for Medical Research. Glasgow, New York, Tokyo, Melbourne, Madras, London: Chapman and Hall, 1991; 433.
24. Jansen PGM, te Velthuis H, Wildevuur WR, Huybregts MAJM, Bulder ER, van der Spoel HI, Sturk A, Eysman L, Wildevuur ChRH. Cardiopulmonary bypass with modified fluid gelatin and heparin-coated circuits. British Journal of Anaesthesia 1996; 76: 13-19.
25. Reilly PM, Bulkley GB. Vasoactive mediators and splanchnic perfusion. Critical Care Medicine 1993; 21 (2) (Suppl): S55-S58.
26. Pogetti RS, Moore FA, Moore EE, Koeike K, Banerjee A. Simultaneous liver and lung injury following gut ischemia is mediated by xanthine oxidase. Journal of Trauma 1992; 32: 723-728.
27. Minami K, Körner MM, Vyska K, Kleesiek K, Knobl H, Körfer R. Effects of pulsatile perfusion on plasma catecholamine levels and hemodynamics during and after cardiac operations with cardiopulmonary bypass. Journal of Thoracic and Cardiovascular Surgery 1990; 99: 82-91.
28. Lameire NH, Matthys E, Kesteloot D, Waterloos MA. Effects of a serotonin blocking agent on renal hemodynamics in the normal rat. Kidney International 1990; 38: 823-828.