Effect of mixed chimerism on graft-versus-host disease, disease recurrence and survival after HLA-identical marrow transplantation for aplastic anemia or chronic myelogenous leukemia

Bone Marrow Transplantation

Volumn 18, Issue 4, 1996, Pages 767-776

  Huss, R ^a   Deeg, H J ^a,b   Gooley, T ^a,b   Bryant, E ^a,b   Leisenring, W ^a,b   Clift, R ^a   Buckner, C D ^a,b   Martin, P ^a,b   Storb, R ^a,b   Appelbaum, F R ^a,b  

^a USA   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Aplastic anemia; CML; Mixed chimerism; Rejection; Relapse

Indexed keywords

BUSULFAN; CYCLOPHOSPHAMIDE;

ADOLESCENT; ADULT; APLASTIC ANEMIA; ARTICLE; BONE MARROW TRANSPLANTATION; CANCER RECURRENCE; CANCER SURVIVAL; CHILD; CHIMERA; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; FEMALE; GRAFT FAILURE; GRAFT VERSUS HOST REACTION; HLA MATCHING; HUMAN; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SIBLING; WHOLE BODY RADIATION;

ADOLESCENT; ADULT; ANEMIA, APLASTIC; BONE MARROW TRANSPLANTATION; CHILD; CHILD, PRESCHOOL; CHIMERA; FEMALE; GRAFT REJECTION; GRAFT VS HOST DISEASE; HLA ANTIGENS; HUMANS; INFANT; LEUKEMIA, MYELOID, CHRONIC; MALE; MIDDLE AGED; RECURRENCE; SURVIVAL RATE; TIME FACTORS; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, HOMOLOGOUS;

EID: 10244244934     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Weiden PL, Flournoy N, Thomas ED et al. Antileukemic effect of graft-versus-host disease in human recipients of allogeneic-marrow grafts. New Engl J Med 1979; 300: 1068-1073.
2. Horowitz MM, Gale RP, Sondel PM et al. Graft-versus-leukemia reactions after bone marrow transplantation. Blood 1990; 75: 555-562.
3. Sullivan KM, Weiden PL, Storb R et al. Influence of acute and chronic graft-versus-host disease on relapse and survival after bone marrow transplantation from HLA-identical siblings as treatment of acute and chronic leukemia. Blood 1989; 73: 1720-1728.
4. Ferrara JLM, Deeg HJ. Graft-versus-host disease. New Engl J Med 1991; 324: 667-674.
5. Anasetti C, Tan P, Hansen JA, Martin PJ. Induction of specific nonresponsiveness in unprimed human T cell by anti-CD3 antibody and alloantigen. J Exp Med 1990; 172: 1691-1700.
6. Schwartz RH. A cell culture model for T lymphocyte clonal anergy. Science 1990; 248: 1349-1356.
7. Jenkins MK. The role of cell division in the induction of clonal anergy. Immunol Today 1992; 13: 69-73.
8. Sharabi Y, Abraham VS, Sykes M, Sachs DH. Mixed allogeneic chimeras prepared by a non-myeloablative regimen: requirement for chimerism to maintain tolerance. Bone Marrow Transplant 1992; 9: 191-197.
9. Sykes M, Romick ML, Hoyles KA, Sachs DH. In vivo administration of interleukin-2 plus T cell-depleted syngeneic marrow prevents graft-versus-host disease mortality and permits alloengraftment. J Exp Med 1990; 171: 645-658.
10. Hill RS, Petersen FB, Storb R et al. Mixed hematologic chimerism after allogeneic marrow trasnplantation for severe aplastic anemia is associated with a higher risk of graft rejection and a lessened incidence of acute graft-versus-host disease. Blood 1986; 67: 811-816.
11. Branch DR, Gallagher MT, Forman SJ et al. Endogenous stem cell repopulation resulting in mixed hematopoietic chimerism following total body irradiation and marrow transplantation for acute leukemia. Transplantation 1982; 34: 226-228.
12. Petz LD. Documentation of engraftment and characterization of chimerism following bone marrow transplantation. In: Forman SJ, Blume KG, Thomas ED (eds). Bone Marrow Transplantation. Blackwell Scientific: Boston, MA, 1994, pp 136-148.
13. Schattenberg A, De Witte T, Saiden M et al. Mixed hematopoietic chimerism after allogeneic transplantation with lymphocyte-depleted bone marrow is not associated with a higher incidence of relapse. Blood 1989; 73: 1367-1372.
14. Bertheas MF, Lafage M, Levy P et al. Influence of mixed chimerism on the results of allogeneic bone marrow transplantation for leukemia. Blood 1991; 78: 3103-3106.
15. Storb R. HLA-identical marrow transplantation for severe aplastic anemia. In: Atkinson K (ed). Clinical Bone Marrow Transplantation: A Reference Textbook. Cambridge University Press: Cambridge, 1994, pp 230-237.
16. Storb R, Anasetti C, Appelbaum F et al. Marrow transplantation for severe aplastic anemia and thalassemia major. Semin Hematol 1991; 28: 235-239.
17. Storb R, Etzioni R, Anasetti C et al. Cyclophosphamide combined with antithymocyte globulin in preparation for allogeneic marrow transplants in patients with aplastic anemia. Blood 1994; 84: 941-949.
18. Deeg HJ, Huss R. Acute graft-versus-host disease. In: Atkinson K (ed). Clinical Bone Marrow Transplantation: A Reference Textbook. Cambridge University Press: Cambridge, 1994, pp 297-311.
19. Storb R, Deeg HJ, Farewell V et al. Marrow transplantation for severe aplastic anemia: methotrexate alone compared with a combination of methotrexate and cyclosporine for prevention of acute graft-versus-host disease. Blood 1986; 68: 119-125.
20. Thomas ED, Clift RA, Fefer A et al. Marrow transplantation for the treatment of chronic myelogenous leukemia. Ann Intern Med 1986; 104: 155-163.
21. Clift RA, Buckner CD, Appelbaum FR et al. Allogeneic marrow transplantation in patients with chronic myeloid leukemia in the chronic phase. A randomized trial of two irradiation regimens. Blood 1991; 77: 1660-1665.
22. Clift RA, Buckner CD, Thomas ED et al. Marrow transplantation for chronic myeloid leukemia: a randomized study comparing cyclophosphamide and total body irradiation with busulfan and cyclophosphamide. Blood 1994; 84: 2036-2043.
23. Storb R, Deeg HJ, Whitehead J et al. Methotrexate and cyclosporine compared with cyclosporine alone for prophylaxis of acute graft-versus-host disease after marrow transplantation for leukemia. New Engl J Med 1986; 314: 729-735.
24. Sandberg AA. Methods. In: The Chromosomes in Human Cancer and Leukemia. Elsevier: New York, 1980.
25. Viard F, Merel P, Bilhou-Nabera C et al. Mixed chimerism after sex-mismatched allogeneic BMT: evaluation of two molecular techniques. Bone Marrow Transplant 1993; 11: 27-31.
26. Cox DR. Regression models and life-tables (with discussions), series B. J Roy Stat Soc 1972; 34: 187-220.
27. Chao NJ, Schmidt GM, Niland JC et al. Cyclosporine, methotrexate, and prednisone compared with cyclosporine and prednisone for prophylaxis of acute graft-versus-host disease. New Engl J Med 1993; 329: 1225-1230.
28. Storb R, Doney KC, Thomas ED et al. Marrow transplantation with or without donor buffy coat cells for 65 transfused aplastic anemia patients. Blood 1982; 59: 236-246.
29. Spitzer TR, Himoe E, Cottler-Fox M et al. Long-term stable mixed chimaerism following allogeneic marrow transplantation for severe aplastic anaemia. Br J Haematol 1990; 76: 146-154.
30. Hows JM, Palmer S, Gordon-Smith EC. Use of cyclosporine A in allogeneic bone marrow transplantation for severe aplastic anemia. Transplantation 1982; 33: 382-386.
31. Keable H, Bourhis J-H, Brison O et al. Long-term study of chimaerism in bone marrow transplantation recipients for severe aplastic anaemia. Br J Haematol 1989; 71: 525-533.
32. Korver K, De Lange GG, van den Bergh RL et al. Lymphoid chimerism after allogeneic bone marrow transplantation. Y-chromatin staining of peripheral T and B lymphocytes and allotyping of serum immunoglobulins. Transplantation 1987; 44: 643-650.
33. Van Leeuwen JEM, van Tol MJD, Joosten AM et al. Persistence of host-type hematopoiesis after allogeneic bone marrow transplantation for leukemia is significantly related to the recipient's age/and or the conditioning regimen, but it is not associated with an increased risk of relapse. Blood 1994; 83: 3059-3067.
34. Roux E, Abdi K, Speiser D et al. Characterization of mixed chimerism in patients with chronic myeloid leukemia transplanted with T cell-depleted bone marrow: involvement of different hematologic lineages before and after relapse. Blood 1993; 81: 243-248.
35. O'Reilly R, Dupont B, Pahwa S et al. Successful hematologic and immunologic reconstitution of severe combined immunodeficiency and secondary aplasia by transplantation of bone marrow from an unrelated HLA-D compatible donor. New Engl J Med 1977; 297: 1311-1318.
36. Buckley RH, Schiff SE, Schiff RI et al. Haploidentical bone marrow stem cell transplantation in human severe combined immunodeficiency. Semin Hematol 1993; 30 (Suppl. 4): 92-104.
37. Fischer A, Friedrich W, Fasth A et al. Reduction of graft failure by a monoclonal antibody (anti-LFA-1 CD11a) after HLA nonidentical bone marrow transplantation in children with immunodeficiencies, osteopetrosis, and Fanconi's anemia: a European Group for Immunodeficiency/European Group for Bone Marrow Transplantation report. Blood 1991; 77: 249-256.
38. O'Reilly RJ, Friedrich W, Small TN. Transplantation approaches for severe combined immunodeficiency disease, Wiskott-Aldrich syndrome, and other lethal genetic, combined immunodeficiency disorders. In: Forman SJ, Blume KG, Thomas ED (eds). Bone Marrow Transplantation. Blackwell Scientific: Boston, MA, 1994, pp 849-873.
39. Wren SM, Nalesnik M, Hronakes ML et al. Mixed chimerism to induce tolerance for solid organ transplantation. J Pediatr Surg 1991; 26: 439-443.
40. Li H, Ricordi C, Demetris AJ et al. Mixed xenogeneic chimerism (mouse + rat → mouse) to induce donor-specific tolerance to sequential or simultaneous islet xenografts. Transplantation 1994; 57: 592-598.
41. Deeg HJ, Self S, Storb R et al. Decreased incidence of marrow graft rejection in patients with severe aplastic anemia: changing impact of risk factors. Blood 1986; 68: 1363-1368.
42. Urdahl KB, Pardoll DM, Jenkins MK. Cyclosporin A inhibits positive selection and delays negative selection in alpha beta TCR transgenic mice. J Immunol 1994; 152: 2853-2859.
43. Gluckman E, Horowitz MM, Champlin RE et al. Bone marrow transplantation for severe aplastic anemia: influence of conditioning and graft-versus-host disease prophylaxis regimens on outcome. Blood 1992; 79: 269-275.
44. Storb R, Thomas ED, Weiden PL et al. One-hundred and ten patients with aplastic anemia (AA) treated by marrow transplantation in Seattle. Transplant Proc 1978; 10: 135-140.
45. McCann SR, Bacigalupo A, Gluckman E et al. Graft rejection and second bone marrow transplants for acquired aplastic anaemia: a report from the Aplastic Anaemia Working Party of the European Bone Marrow Transplant Group. Bone Marrow Transplant 1994; 13: 233-237.
46. Ramsay NKC, Kim T, Nesbit ME et al. Total lymphoid irradiation and cyclophosphamide as preparation for bone marrow transplantation in severe aplastic anemia. Blood 1980; 55: 344-346.
47. Goldman JM, Gale RP, Horowitz MM et al. Bone marrow transplantation for chronic myelogenous leukemia in chronic phase: increased risk of relapse associated with T-cell depletion. Ann Intern Med 1988; 108: 806-814.
48. Cross NC, Hughes TP, Feng L et al. Minimal residual disease after allogeneic bone marrow transplantation for chronic myeloid leukaemia in first chronic phase: correlations with acute graft-versus-host disease and relapse. Br J Haematol 1993, 84: 67-74.
49. Hughes TP, O'Shea P, Morgan G et al. Persistence of BCR/ABL transcripts after BMT for CML detected by PCR reflects a high risk of relapse. Bone Marrow Transplant 1991; 7 (Suppl. 2): 23.
50. Radich JP, Gehly G, Gooley E et al. Polymerase chain reaction detection of the BCR-ABL fusion transcript after allogeneic marrow transplantation for chronic myeloid leukemia: results and implications in 346 patients. Blood 1995; 85: 2632-2638.
51. Miyamura K, Barrett AJ, Kodera Y, Saito H. Minimal residual disease after bone marrow transplantation for chronic myelogenous leukemia and implications for graft-versus-leukemia effect: a review of recent results. Bone Marrow Transplant 1994; 14: 201-209.
52. Kolb H-J, Schattenberg A, Goldman JM et al. Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. Blood 1995; 86: 2041-2050.
53. Van Rhee F, Lin F, Cullis JO et al. Relapse of chronic myeloid leukemia after allogeneic bone marrow transplant: the case for giving donor leukocyte transfusions before the onset of hematologic relapse. Blood 1994; 83: 3377-3383.