An alcohol hand rub containing a synergistic combination of an emollient and preservatives: Prolonged activity against transient pathogens

Journal of Hospital Infection

Volumn 59, Issue 1, 2005, Pages 12-18

  Gaonkar, T A ^a   Geraldo, I ^a   Caraos, L ^a   Modak, S M ^a  

^a Columbia University ^*  (United States)

Author keywords

Alcohol hand antiseptic; Antimicrobial efficacy; Pig skin model

Indexed keywords

ALCOHOL; ANTIINFECTIVE AGENT; AVAGARD; BENZALKONIUM CHLORIDE; CHLORHEXIDINE GLUCONATE; EMOLLIENT AGENT; METICILLIN; OCTOXYGLYCERINE; PLACEBO; PREVACARE; SENSIVA; UNCLASSIFIED DRUG; VANCOMYCIN;

ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL COUNT; BACTERICIDAL ACTIVITY; BACTERIUM CONTAMINATION; CONTROLLED STUDY; DILUTION; DISINFECTION; DRUG EFFICACY; DRUG EXPOSURE; DRUG FORMULATION; ENTEROCOCCUS FAECIUM; ESCHERICHIA COLI; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; IN VIVO STUDY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; NORMAL HUMAN; PERSONAL HYGIENE; SKIN INFECTION; STAPHYLOCOCCUS EPIDERMIDIS; SWINE; VOLUNTEER;

ADMINISTRATION, CUTANEOUS; ALCOHOLS; ANIMALS; BACTERIAL INFECTIONS; CHEMISTRY, PHARMACEUTICAL; COLONY COUNT, MICROBIAL; CROSS INFECTION; DISINFECTANTS; DRUG COMBINATIONS; DRUG EVALUATION, PRECLINICAL; EMOLLIENTS; ENTEROCOCCUS FAECIUM; HAND; HANDWASHING; HUMANS; METHICILLIN RESISTANCE; PRESERVATIVES, PHARMACEUTICAL; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; SWINE; TIME FACTORS; VANCOMYCIN RESISTANCE;

EID: 10244240668     PISSN: 01956701     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhin.2004.06.030     Document Type: Article

References (27)

1. E.J. Fendler Y. Ali B.S. Hammond M.K. Lyons M.B. Kelley N.A. Vowell The impact of alcohol hand sanitizer use on infection rates in extended care facilities Am J Infect Control 30 2002 226-233
2. B.N. Doebbeling G.L. Stanley C.T. Sheetz et al. Comparative efficacy of alternative hand washing agents in reducing nosocomial infections in intensive care units New Engl J Med 327 1992 88-93
3. E. Larson J.J. Leyden K.J. McGinley G.L. Grove G.H. Talbot Physiologic and microbiologic changes in skin related to frequent hand washing Infect Control 7 1986 59-63
4. P.D. Meers G.A. Yeo Shedding of bacteria and skin squames after hand washing J Hyg (Lond) 81 1978 99-105
5. E. Larson M. Killien Factors influencing hand washing behavior of patient care personnel Am J Infect Control 10 1982 93-99
6. A. Voss A.F. Widmer No time for hand washing? Hand washing versus alcoholic rub: can we afford 100% compliance? Infect Control Hosp Epidemiol 18 1997 205-208
7. J.M. Boyce S. Kelliher N. Vallande Skin irritation and dryness associated with two hand hygiene regimens: soap and water hand washing versus hand antisepsis with an alcoholic hand gel Infect Control Hosp Epidemiol 21 2000 442-448
8. M.R. Meengs B.K. Giles C.D. Chisholm W.H. Corell D.R. Nelson Hand washing frequency in an emergency department J Emerg Nurs 20 1994 183-188
9. W.E. Biscoff T.M. Reynolds C.N. Sessler M.B. Edmond R.P. Wenzel Hand washing compliance by health care workers. The impact of introducing an accessible alcohol based hand antiseptic Arch Intern Med 160 2000 1017-1021
10. R. Girard K. Amazian J. Fabry Better compliance and better tolerance in relation to a well conducted introduction to rub-in hand disinfection J Hosp Infect 47 2001 131-137
11. S. Hugonnet T.V. Perneger D. Pittet Alcohol based hand rub improves compliance with hand hygiene in intensive care units Arch Int Med 162 2002 1037-1043
12. D. Pittet S. Hugonnet S. Harbarth et al. Effectiveness of a hospital-wide program to improve compliance with hand hygiene Lancet 356 2000 1307-1312
13. E. Larson Skin hygiene and infection prevention: more of the same or different approaches? Clin Infect Dis 29 1999 1287-1294
14. E.J. Lowbury H.A. Lilly G.A.J. Ayliffe Preoperative skin disinfection of surgeon's hands: use of alcoholic solutions and effects of gloves on skin flora BMJ 4 1974 369-372
15. G.A.J. Ayliffe Surgical scrub and skin disinfection Infect Control 5 1984 23-27
16. L.W. Bush L.M. Benson J.H. White Pig skin as test substrate for evaluating topical antimicrobial activity J Clin Microbiol 24 1986 343-348
17. P. Goroncy-Bermes M.A. Schouten A. Voss In vitro activity of a non medicated hand wash product, chlorhexidine, and an alcohol based hand disinfectant against multiply resistant Gram positive microorganisms Infect Control Hosp Epidemiol 22 2001 194-196
18. J.C. Lucet M.P. Rigaud F. Mentre et al. Hand contamination before and after different hand hygiene techniques: a randomized clinical trial J Hosp Infect 50 2002 276-280
19. M.L. Rotter Alcohols for antisepsis of hands and skin In: J.M. Ascenzi editor. Handbook of disinfectants and antiseptics 1996 Marcel Dekker New York 177-233
20. M.L. Rotter Hand washing and hand disinfection In: C.G. Mayhall editor. Hospital epidemiology and infection control 1996 Williams and Wilkins Baltimore 1052-1068
21. M.L. Rotter Hygienic hand disinfection Infect Control 5 1984 18-22
22. D.L. Bissett J.F. McBride The use of the domestic pig as an animal model for human dry skin and for comparison of dry and normal skin properties J Soc Cosmet Chem 34 1983 317-326
23. W. Meyer R. Schwarz K. Neurand The skin of domestic mammals as a model for the human skin, with special reference to the domestic pig Curr Probl Dermatol 7 1978 39-52
24. M. Bruch Newer germicides: what they offer In: H. Maibach R. Aly editors. Skin microbiology: relevance to clinical infection 1981 Spinger-Verlag New York 103-112
25. R. Aly H.I. Malibach Factors controlling skin bacterial flora In: H. Malibach R. Aly editors. Skin microbiology: relevance to clinical infection 1981 Springer-Verlag New York 29-39
26. M.L. Rotter Hand washing and hand disinfection In: C.G. Mayhall editor. Hospital epidemiology and infection control 2nd edn 1999 Lippincott Williams and Wilkins Philadelphia 1339-1355
27. M.L. Rotter Arguments for alcoholic hand disinfection J Hosp Infect 48 2001 S4-S8