Inhibition of small-intestinal sugar absorption mediated by sodium orthovanadate Na3VO4 in rats and its mechanisms

World Journal of Gastroenterology

Volumn 10, Issue 24, 2004, Pages 3612-3615

  Ai, Jing ^a   Du, Jie ^a   Wang, Ning ^a   Du, Zhi Min ^a   Yang, Bao Feng ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GLUCOSIDASE; CARBOHYDRATE; GLUCOSE; GLUCOSE TRANSPORTER 2; MALTOSE; MESSENGER RNA; VANADATE SODIUM;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CARBOHYDRATE ABSORPTION; CONTROLLED STUDY; DIET RESTRICTION; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME ISOLATION; FEMALE; FOOD INTAKE; GLUCOSE ABSORPTION; IN SITU HYBRIDIZATION; INHIBITION KINETICS; INTESTINE EPITHELIUM CELL; LAVAGE; MALE; NONHUMAN; OXIDATION; PROTEIN EXPRESSION; RAT; SMALL INTESTINE ABSORPTION;

EID: 10244236574     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v10.i24.3612     Document Type: Article

References (20)

1. Meyerovitch J, Farfel Z, Sack J, Shechtery Y. Oral administration of vanadate normalizes blood glucose levels in streptozotocin-treated rats. Characterization and mode of action. J Biol Chem 1987; 262: 6658-6662
2. Meyerovitch J, Waner T, Sack J, Kopolovic J, Shemer J. Attempt to prevent the development of diabetes in non-obese diabetic mice by oral vanadate administration. Isr Med Assoc J 2000; 2: 211-214
3. Shao J, Catalano PM, Yamashita H, Ishizuka T, Friedman JE. Vanadate enhances but does not normalize glucose transport and insulin receptor phosphorylation in skeletal muscle from obese women with gestational diabetes mellitus. Am J Obstet Gynecol 2000; 183: 1263-1270
4. Marita AR, Anilkumar KL. Effect of vanadate on glycogen synthesis in dexamethasone-treated 3T3 adipocytes: evidence for a novel insulin sensitizing action. Diabetes Obes Metab 2001; 3: 271-278
5. Pugazhenthi S, Khandelwal RL, Angel JF. Insulin-like effect of vanadate on malic enzyme and glucose-6-phosphate dehydrogenase activities in streptozotocin-induced diabetic rat liver. Biochim Biophys Acta 1991; 1083: 310-312
6. Madsen KL, Ariano D, Fedorak RN. Vanadate treatment rapidly improves glucose transport and activates 6-phosphofructo-1-kinase in diabetic rat intestine. Diabetologia 1995; 38: 403-412
7. O'Connor JC, Freund GG. Vanadate and rapamycin synergistically enhance insulin-stimulated glucose uptake. Metabolism 2003; 52: 666-674
8. Kellett GL, Barker ED. The effect of vanadate on glucose transport and metabolism in rat small intestine. Biochim Biophys Acta 1989; 979: 311-315
9. Hudgins PM, Bond GH. Alteration by vanadate of contractility in vascular and intestinal smooth muscle preparations. Pharmacology 1981; 23: 156-164
10. Zhang JT, Shen ZF, Qiao FX. α-glucosidase activity assay. Modern experimental methods in pharmacology (1). First edition. Peking. Peking Medical University and Xie-he Medical University Publishing Company 1998: 992
11. Yasuda K, Shimowada K, Uno M, Odaka H, Adachi T, Shihara N, Suzuki N, Tamon A, Nagashima K, Hosokawa M, Tsuda K, Seino Y. Long-term therapeutic effects of voglibose, a potent intestinal alpha-glucosidase inhibitor, in spontaneous diabetic GK rats. Diabetes Res Clin Pract 2003; 59: 113-122
12. Wehmeier UF, Piepersberg W. Biotechnology and molecular biology of the alpha-glucosidase inhibitor acarbose. Appl Microbiol Biotechno 2004; 63: 613-625
13. Ron Y, Wainstein J, Leibovitz A, Monastirsky N, Habot B, Avni Y, Segal R. The effect of acarbose on the colonic transit time of elderly long-term care patients with type 2 diabetes mellitus. J Gerontol A Biol Sci Med Sci 2002; 57: M111-M114
14. Gupta D, Raju J, Prakash J, Baquer NZ. Change in the lipid profile, lipogenic and related enzymes in the livers of experimental diabetic rats: effect of insulin and vanadate. Diabetes Res Clin Pract 1999; 46: 1-7
15. Goldwaser I, Gefel D, Gershonov E, Fridkin M, Shechter Y. Insulin-like effects of vanadium: basic and clinical implications. J Inorg Biochem 2000; 80: 21-25
16. Rowe WA, Tomicic TK, Hajjar JJ. Enhancement of rat intestinal calcium absorption by vanadate. Proc Soc Exp Biol Med 1991; 198: 754-759
17. Bischoff H. Pharmacology of alpha-glucosidase inhibition. Eur J Clin Invest 1994; 24(Suppl 3): 3-10
18. Ranganath L, Norris F, Morgan L, Wright J, Marks V. Delayed gastric emptying occurs following acarbose administration and is a further mechanism for its anti-hyperglycaemic effect. Diabet Med 1998; 15: 120-124
19. Joubert PH, Venter HL, Foukaridis GN. The effect of miglitol and acarbose after an oral glucose load: a novel hypoglycaemic mechanism? Br J Clin Pharmacol 1990; 30: 391-396
20. Scheiner-Bobis G, Hubschle T, Diener M. Action of palytoxin on apical H+/K+-ATPase in rat colon. Eur J Biochem 2002; 269: 3905-3911