Protective effect of B464, a lipid A analog, on endotoxin-induced cellular responses and acute lung injury

American Journal of Respiratory and Critical Care Medicine

Volumn 154, Issue 4 I, 1996, Pages 900-906

  Soejima, Kenzo ^b   Ishizaka, Akitoshi ^a   Urano, Tetsuya ^b   Sayama, Koichi ^b   Sakamaki, Fumio ^b   Nakamura, Hidetoshi ^b   Terashima, Takeshi ^b   Waki, Yasuhiro ^b   Tasaka, Sadatomo ^b   Fujishima, Seitaro ^b   Kawata, Tsutomu ^b   Christ, William J ^b   Kanazawa, Minoru ^b  

^a KEIO UNIVERSITY   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

B 464; ENDOTOXIN; LIPID A DERIVATIVE; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; GUINEA PIG; HUMAN; HUMAN CELL; LEUKOCYTE ACTIVATION; LUNG FLUID; LUNG INJURY; LUNG PARENCHYMA; MONOCYTE; NEUTROPENIA; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL;

EID: 10244235262     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.154.4.8887583     Document Type: Article

References (35)

1. Ashbaugh, D. G., D. B. Bigelow, T. L. Petty, and B. E. Levine. 1967. Acute respiratory distress in adults. Lancet 2:319-323.
2. Weiland, J. E., W. B. Davis, J. F. Holter, J. R. Mohammed, P. M. Dorinsky, and J. E. Gadek. 1986. Lung neutrophils in the adult respiratory distress syndrome. Clinical and pathologic significance. Am. Rev. Respir. Dis. 133:218-225.
3. Brigham, K. L., and B. Meyrick. 1986. Endotoxin and lung injury. Am. Rev. Respir. Dis. 133:913-927.
4. Van Dervort, A. L., M. E. Doerfler, P. Stuetz, and R. L. Danner. 1992. Antagonism of lipopolysaccharide-induced priming of human neutrophils by lipid A analogs. J. Immunol. 149:359-366.
5. Danner, R. L., K. A. Joiner, and J. E. Parrillo. 1987. Inhibition of endotoxin-induced priming of human neutrophils by lipid X and 3-Aza-lipid X. J. Clin. Invest. 80:605-612.
6. Danner, R. L., P. Q. Eichacker, M. E. Doerfler, W. D. Hoffman, J. M. Reilly, J. Wilson, T. J. MacVittie, P. Stuetz, J. E. Parrillo, and C. Natanson. 1993. Therapeutic trial of lipid X in a canine model of septic shock. J. Infect. Dis. 149:359-366.
7. Rackow, E. C., M. E. Astiz, Y. B. Kim, and M. H. Weil. 1989. Monophosphoryl lipid A blocks the hemodynamic effects of lethal endotoxemia. J. Lab. Clin. Med. 113:112-117.
8. Golenbock, D. T., J. E. Legett, P. Rasmussen, W. A. Craig, C. R. H. Raetz, and R. A. Proctor. 1988. Lipid X protects mice against fatal Escherichia coli infection. Infect. Immun. 56:779-784.
9. McCloskey, R. V., R. C. Straube, C. Sanders, S. M. Smith, C. R. Smith, and the CHESS Trial Study Group. 1994. Treatment of septic shock with human monoclonal antibody HA-1A. A randomized, double-blind, placebo-controlled trial. Ann. Intern. Med. 121:1-5.
10. Lam, C., J. Hildebrandt, E. Schutze, B. Rosenwirth, R. A. Proctor, and P. Stutz. 1991. Immunostimulatory, but not antiendotoxin, activity of lipid X is due to small amounts of contaminating N,O-acylated disaccharide-1-phosphate: in vitro and in vivo reevaluation of the biological activity of synthetic lipid X. Infect. Immun. 59:2351-2358.
11. Wang, S. C., D. P. Rossignol, W. J. Christ, D. A. Geller, P. D. Fresswick, N. L. Thai, G. L. Su, and R. L. Simmons. 1994. Suppression of lipopolysaccharide-induced macrophage nitric oxide and cytokine production in vitro by a novel lipopolysaccharide antagonist. Surgery 116:339-347.
12. Goldstein, I. M., M. Brai, A. G. Osler, and G. Weissman. 1973. Lysosomal enzyme release from human leukocytes: mediation by the alternate pathway of complement activation. J. Immunol. 111:33-37.
13. Bass, D. A., J. W. Parce, L. R. Dechatelet, P. Szejda, M. C. Seeds, and M. Thomas. 1983. Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation. J. Immunol. 130:1910-1917.
14. Howard, T. H., and W. H. Meyer. 1984. Chemotactic peptide modulation of actin assembly and locomotion in neutrophils. J. Cell Biol. 98:1265-1271.
15. Howard, T. H., and C. O. Oresajo. 1985. The kinetics of chemotactic peptide-induced change in F-actin content, F-actin distribution, and the shape of neutrophils. J. Cell Biol. 101:1078-1085.
16. Erzurum, S. C., G. P. Downey, D. E. Doherty, B. Schwab, III, E. L. Elson, and G. S. Worthen. 1992. Mechanisms of lipopolysaccharide-induced neutrophil retention. Relative contributions of adhesive and cellular mechanical properties. J. Immunol. 149:154-162.
17. Freyburger, G., F. Belloc, and M. R. Boisseau. 1990. Pentoxifylline inhibits actin polymerization in human neutrophils after stimulation by chemoattractant factor. Agents Actions 31:72-78.
18. Komatsu, H., M. Nagasawa, and T. Okamoto. 1993. Inhibition of leukocyte adhesion to endothelial cells of human umbilical vein by Y-24180, an antagonist of platelet-activating factor. Int. J. Immunopharmacol. 15:737-744.
19. Kanazawa, M., A. Ishizaka, N. Hasegawa, Y. Suzuki, and T. Yokoyama. 1992. Granulocyte colony-stimulating factor does not enhance endotoxin-induced acute lung injury in guinea pigs. Am. Rev. Respir. Dis. 145:1030-1035.
20. Ishizaka, A., Z., W. Kenton, K. E. Stephens, H. Harada, R. S. Houge, P. T. Hogue, P. T. O'Hanley, and T. A. Raffin. 1988. Attenuation of acute lung injury in septic guinea pigs by pentoxifylline. Am. Rev. Respir. Dis. 138:376-382.
21. Stephens, K. E., A. Ishizaka, J. W. Larrick, and T. A. Raffin. 1987. Tumor necrosis factor causes increased pulmonary permeability and edema. Am. Rev. Respir. Dis. 137:1364-1370.
22. Kanazawa, M., N. Hasegawa, T. Urano, K. Sayama, S. Tasaka, F. Sakamaki, H. Nakamura, T. Terashima, S. Fujishima, and A. Ishizaka. 1994. Regional lung hematocrit variation and assessment of acute lung injury. J. Appl. Physiol. 77:567-573.
23. Ruff, M. R., and G. E. Glifford. 1980. Purification and physico-chemical characterization of rabbit tumor necrosis factor. J. Immunol. 125: 1671-1677.
24. Tracey, K. J., B. Beutler, S. F. Lowry, J. Merryweather, S. Wolpe, I. W. Milsark, R. J. Hariri, T. J. Fahey, III, A. Zentella, J. D. Albert, G. T. Shires, and A. Cerami. 1986. Shock and tissue injury induced by recombinant human cachectin. Science 234:470-474.
25. Michie, H. R., K. R. Manogue, D. R. Spriggs, A. Revhaug, S. O'Dwyer, and C. A. Dinarello. 1988. Detection of circulating tumor necrosis factor after endotoxin administration. N. Engl. J. Med. 318:1481-1486.
26. Haslett, C., L. A. Guthrie, M. M. Kopaniak, R. B. Johnson, and P. M. Henson. 1985. Modulation of multiple neutrophil functions by preparative methods or trace concentrations of bacterial lipopolysaccharide. Am. J. Pathol. 119:101-110.
27. Opdahl, H. 1993. Direct and indirect effecls of E. coli lipopolysaccharide on isolated human polymorphonuclear granulocytes and mixed leukocytes. Inflammation 17:57-75.
28. Ishizaka, A., N. Hasegawa, F. Sakamaki, S. Tasaka, H. Nakamura, K. Kishikawa, A. Yamada, T. Obata, K. Sayama, T. Urano, and M. Kanazawa. 1994. Effecls of ONO-1078, a peptide leukotriene antagonist, on endotoxin-induced acute lung injury. Am. J. Respir. Crit. Care Med. 150:1325-1331.
29. Worthen, G. C., B. Schwab, III, E. L. Elson, and C. P. Downey. 1989. Mechanics of stimulated neutrophils: cell stiffening induces retention in capillaries. Science 245:183-186.
30. Marks, R. M., R. F. Todd III, and P. A. Ward. 1989. Rapid induction of neutrophil-endothelial adhesion by endothelial complement fixation. Nature 339:314-317.
31. 4 in the human lung. Recruitment of neutrophils into the alveolar spaces without a change in prolein permeability. J. Clin. Invest. 84:1609-1619.
32. Chang, S., S. Fernyak, and N. F. Voelkel. 1990. Beneficial effect of a platelet-activating factor antagonist, WEB 2086, on endotoxin-induced lung injury. Am. J. Physiol. 256:H153-H158.
33. Springer, T. A. 1990. Adhesion receptors of the immune system. Nature 346:425-434.
34. Butcher, F. C. 1991. Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Minireview. Cell 67:1033-1036.
35. Lynn, W. A., C. R. H. Raetz, N. Qureshi, and D. T. Golenbock. 1991. Lipopolysaccharide-induced stimulation of CD11b/CD18 expression on neutrophils. Evidence of specific receptor-based response and inhibition by lipid A-based antagonists. J. Immunol. 147:3072-3079.