Intermittent hypoxia causes a suppressed pituitary growth hormone through somatostatin

Neuroendocrinology Letters

Volumn 25, Issue 5, 2004, Pages 361-367

  Xu, Ning Yi ^a   Chen, Xue Qun ^a   Du, Ji Zeng ^a   Wang, Tong Ying ^a   Duan, Cunming ^b  

^a ZHEJIANG UNIVERSITY   (China)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Cysteamine; Growth hormone; Intermittent hypoxia; Rat; Somatostatin

Indexed keywords

GROWTH HORMONE; HYPOTHALAMUS HORMONE; MERCAPTAMINE; MESSENGER RNA; SOMATOSTATIN;

ADENOHYPOPHYSIS; ALTITUDE; ALTITUDE DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXPOSURE; GROWTH HORMONE RELEASE; HORMONE INHIBITION; HYPOBARISM; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; MALE; MEDIAN EMINENCE; NONHUMAN; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE; WEIGHT GAIN;

EID: 10244234143     PISSN: 0172780X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Nelson ML, Cons JM. Pituitary hormone and growth retardation in rats raised at simulated high attitude (3800m). Environ Physiol Biochem 1975; 5:273-282.
2. DeMeer K, Heymans HS, Zijlstra WG. Physical adaptation of children to life at high altitude. Eur J Pediatr 1995; 154:263-272.
3. Du JZ, Li QF. Effects of simulated hypoxic acclimation on organism, organ and hematology in Ochotona Curzoniae and rats. Acta Theriologica Sin 1982; 2:35-42.
4. Yang SM, Du JZ, Li LC. Effect of hypoxia on the development of hypothalamic corticotropin-releasing factor of neonatal rats. Chin J Appl Physiol 1996; 12:294-297.
5. Zhang YS, Du JZ. The response of growth hormone and prolactin of rats to hypoxia. Neurosci Lett 2000; 279:137-140.
6. Codner E, Cassorla F. Growth hormone and reproductive function. Mol Cell Endocrinol 2002; 186:133-136.
7. Hull KL, Harvey S. Growth hormone therapy and Quality of Life: possibilities, pitfalls and mechanisms. J Endocrinol 2003; 179 311-333.
8. Scacchi M, Pincelli AI, Cavagnini F. Nutritional status in the neuroendocrine control of growth hormone secretion: the model of anorexia nervosa. Front Neuroendocrin 2003; 24:200-224.
9. Muller EE, Locatelli V, Cocchi D. Neuroendocrine control of growth hormone secretion. Physiol Rev 1999; 79:511-607.
10. Lopez M, Seoane LM, Tovar S, Nogueiras R, Dieguez C, Senaris R. Orexin-A regulates growth hormone-releasing hormone mRNA content in a nucleus-specific manner and somatostatin mRNA content in a growth hormone-dependent fashion in the rat hypothalamus. Eur J Neurosci 2004; 19:2080-2088.
11. Tannenbaum GS. Neuroendocrine control of growth hormone secretion. Acta Paediatr Scand 1991; [Suppl] 372:5-16.
12. Chen XQ, Du JZ. Increased somatostatin mRNA expression in periventricular nucleus of rat hypothalamus during hypoxia. Regul Peptides 2002; 105:197-201.
13. Sagar SM, Landry D, Millard WJ, Badger TM, Arnold MA and Martin JB. Depletion of somatostatin-like immunoreactivity in the rat central nervous system by cysteamine, J Neurosci 1982; 2:225-231.
14. Patel YC, Pierzchala I. Cysteamine induces a loss of tissue somatostatin-28 when measured as somatostatin-28(15-28)-like immunoreactivity but not when assessed as somatostatin-28(1-14)-like immunoreactivity: evidence for the importance of the disulfide bond for cysteamine action. Endocrinology 1985; 116:1699-1702.
15. Justino L, Welner SA, Tannenbaum GS and Schipper HM. Long-term effects of cysteamine on cognitive and locomotor behavior in rats: relationship to hippocampal glial pathology and somatostatin levels. Brain Res 1997; 761:127-134.
16. Yoshizato H, Fujikawa T, Soya H, Tanaka M, Nakashima K. The growth hormone (GH) gene is expressed in the lateral hypothalamus: enhancement by GH-releasing hormone and repression by restraint stress. Endocrinology 1998; 139:2545-2551.
17. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. Orlando: Academic Press 1986.
18. Bhatnagar M. Distribution of somatostatin (SS) immunoreactivity using specific rabbit antibodies in preoptic-anterior hypothalamus (PO-AH) of female rat brain. Brain Res 2001; 900 295-305.
19. Tannenbaum GS, McCarthy GF, Zeitler P and Beaudet A. Cysteamine-Induced Enhancement of Growth hormone-Releasing Factor (GRF) Immunorectivity in Arcuate Neurons: Morphological Evidence for Putative Somatostatin/GRF Interactions within Hypothalamus. Endocrinology 1990; 127:2551-2560.
20. Arancibia S, Lyonnet D, Roussel JP, Ixart G, Astier H. The inhibitory effect of picrotoxin on basal and cold-induced thyrotropin secretion involves somatostatin mediation. Neurosci Lett 1995; 185: 139-143.
21. Brogan RS, Fife SK, Conley LK, Giustina A, Wehrenberg WB. Effect of food deprivation on the GH axis: immunocytochemical and molecular analysis. Neuroendocrinology 1997; 65:129-135.
22. Ishikawa M, Mizobuchi M, Takahashi H. Somatostatin release as measured by in vivo microdialysis: circadian variation and effect of prolonged food deprivation. Brain Res 1997; 749:226-231.
23. Toppila J, Niittymaki P, Porkka-Heiskanen T, Stenberg D. Intracerebroventricular and locus coeruleus microinjections of somatostatin antagonist decrease REM sleep in rats. Pharmacol Biochem Behav 2000; 66:721-727.
24. Zhang K, Hamanaka K, Kitayama I, Soya H, Yoshizato H, Nakase S, et al. Decreased expression of the mRNA for somatostatin in the periventricular nucleus of depression-model rats. Life Sci 1999; 65 PL87-94.
25. Estupina C, Abarca J, Arancibia S, Belmar J. N-MethyL-D-aspartate receptor involvement in dexamethasone and stress-induced hypothalamic somatostatin release in rats. Neurosci Lett 1996; 219: 203-206.
26. Chen XQ, Du JZ. Hypoxia influences somatostatin release in rats. Neurosci Lett 2000; 284:151-154.
27. Terry LC, Willoughy JO, Brazeau P, Martin JB and Patel Y. Antiserum to somatostatin prevents stress-induced inhibition of growth hormone secretion in the rat. Science 1976; 192:565-567.
28. Hisano S, Daikoku S. Existence of mutual synaptic relations between corticotropin-releasing factor-containing and somatostatin-containing neurons in the rat hypothalamus. Brain Res 1991; 545: 265-275.
29. Du JZ. The brain CRF during hypoxia. In: Ohno H, Kobayashi T, Nasuyama S, Nakashima M (Ed.), Progress in mountain medicine and high altitude physiology. Japan: Matsumoto, Press Committee of the 3rd World Congress on Mountain Medicine and Altitude physiology 1998; 416-417.