Ezetimibe - A new cholesterol-lowering drug

Drug and Therapeutics Bulletin

Volumn 42, Issue 9, 2004, Pages 65-67

[No Author Info available]

Author keywords

[No Author keywords available]

Indexed keywords

ATORVASTATIN; CHOLESTEROL; EZETIMIBE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYPOCHOLESTEROLEMIC AGENT; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; PRAVASTATIN; SIMVASTATIN; SITOSTEROL;

ABDOMINAL PAIN; ANGIONEUROTIC EDEMA; ARTICLE; AUTOSOMAL RECESSIVE DISORDER; CHOLESTEROL BLOOD LEVEL; CLINICAL PRACTICE; CLINICAL TRIAL; DIARRHEA; DIET THERAPY; DISEASE SEVERITY; DOSE RESPONSE; DRUG CONTRAINDICATION; DRUG COST; DRUG EFFICACY; DRUG ERUPTION; DRUG HYPERSENSITIVITY; DRUG INDICATION; DRUG MECHANISM; DRUG METABOLISM; HEADACHE; HUMAN; HYPERCHOLESTEROLEMIA; ISCHEMIC HEART DISEASE; LIVER DYSFUNCTION; MONOTHERAPY; RISK ASSESSMENT; SITOSTEROLEMIA; STROKE;

EID: 10244229843     PISSN: 00126543     EISSN: None     Source Type: Journal    
DOI: 10.1136/dtb.2004.42965     Document Type: Article

References (13)

1. Ezetrol 10mg tablets. Summary of product characteristics, UK. MSD-SP Ltd, January 2004.
2. Salen G et al. Ezetimibe effectively reduces plasma plant sterols in patients with sitosterolemia. Circulation 2004; 109: 966-71.
3. Dujovne CA et al. Efficacy and safety of a potent new selective cholesterol absorption inhibitor, ezetimibe, in patients with primary hypercholesterolemia. Am J Cardiol 2002; 90: 1092-7.
4. Knopp RH et al. Effects of ezetimibe, a new cholesterol absorption inhibitor, on plasma lipids in patients with primary hypercholesterolemia. Eur Heart J 2003; 24: 729-41.
5. Ballantyne CM et al. Effect of ezetimibe coadministered with atorvastatin in 628 patients with primary hypercholesterolaemia. A prospective, randomized, double-blind trial. Circulation 2003; 107: 2409-15.
6. Davidson MH et al. Ezetimibe coadministered with simvastatin in patients with primary hypercholesterolaemia. J Am Coll Cardiol 2002; 40: 2125-34.
7. Goldberg AC et al. Efficacy and safety of ezetimibe coadministered with simvastatin in patients with primary hypercholesterolaemia: a randomized double-blind, placebo-controlled trial. Mayo Clin Proc 2004; 79: 620-9.
8. Melani L et al. Efficacy and safety of ezetimibe coadministered with pravastatin in patients with primary hypercholesterolaemia: a prospective, randomized, double-blind trial. Eur Heart J 2003; 24: 717-28.
9. Feldman T et al. Treatment of high-risk patients with ezetimibe plus simvastatin co-administration versus simvastatin alone to attain National Cholesterol Education Program Adult Treatment Panel III low-density lipoprotein cholesterol goals. Am J Cardiol 2004; 93: 1481-6.
10. Ballantyne CM et al. Efficacy and safety of ezetimibe co-administered with simvastatin compared with atorvastatin in adults with hypercholesterolemia. Am J Cardiol 2004; 93: 1487-94.
11. Gagné C et al. Efficacy and safety of ezetimibe added to ongoing statin therapy for treatment of patients with primary hypercholesterolaemia. Am J Cardiol 2002; 90: 1084-91.
12. Gagné C et al. Efficacy and safety of ezetimibe coadministered with atorvastatin or simvastatin in patients with homozygous familial hypercholesterolaemia. Circulation 2002; 105: 2469-75.
13. Law MR et al. Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis. BMJ 2003; 326: 1423-7.