3-Amino-3,4-dihydro-2H-1-benzopyran derivatives as 5-HT(1A) receptor ligands and potential anxiolytic agents. 2. Synthesis and quantitative structure-activity relationship studies of spiro[pyrrolidine- and piperidine- 2,3'(2'H)-benzopyrans]

Journal of Medicinal Chemistry

Volumn 39, Issue 21, 1996, Pages 4285-4298

  Comoy, Corinne ^a   Marot, Christophe ^a   Podona, Tchao ^a   Baudin, Marie Laure ^a   Morin Allory, Luc ^a   Guillaumet, Gérald ^a   Pfeiffer, Bruno ^b   Caignard, Daniel Henry ^b   Renard, Pierre ^b   Rettori, Marie Claire ^c   Adam, Gérard ^b   Guardiola Lemaître, Béatrice ^c  

^a UNIVERSITÉ D'ORLÉANS   (France)

^b ADIR   (France)

^c INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOPYRAN DERIVATIVE; PYRROLIDINE DERIVATIVE; SEROTONIN RECEPTOR;

AMINO ACID SUBSTITUTION; ARTICLE; DOPAMINERGIC TRANSMISSION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; LIGAND BINDING; NONHUMAN; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; THERMOREGULATION; TRANQUILIZING ACTIVITY;

ANIMALS; ANTI-ANXIETY AGENTS; BENZOPYRANS; CYCLIC AMP; FORSKOLIN; HIPPOCAMPUS; MAZE LEARNING; MICE; MODELS, MOLECULAR; RATS; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 10244221227     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950861w     Document Type: Article

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