Comparative analysis of protein unfoldedness in human housekeeping and non-housekeeping proteins

Bioinformatics

Volumn 20, Issue 17, 2004, Pages 2904-2910

  Pandey, Neeraj ^a   Ganapathi, Mythily ^a   Kumar, Kaushal ^a   Dasgupta, Dipayan ^a   Das Sutar, Sushanta Kumar ^a   Dash, Debasis ^a  

^a CSIR INSTITUTE OF GENOMICS AND INTEGRATIVE BIOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; EVOLUTIONARY HOMOLOGY; GENETIC ANALYSIS; HOUSEKEEPING GENE; HUMAN; HUMAN CELL; HYDROPHOBICITY; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; SCORING SYSTEM; SEQUENCE HOMOLOGY;

CAENORHABDITIS; CAENORHABDITIS ELEGANS; DROSOPHILA MELANOGASTER; HOMO; HOMO SAPIENS; MELANOGASTER; MUS; MUS MUSCULUS; MUSCULUS;

EID: 10244221154     PISSN: 13674803     EISSN: 13674811     Source Type: Journal    
DOI: 10.1093/bioinformatics/bth344     Document Type: Article

References (16)

1. Brown,C.J., Takayama,S., Campen,A.M., Vise,P., Marshall,T.W., Oldfield,C.J., Williams,C.J. and Dunker,A.K. (2002) Evolutionary rate heterogeneity in proteins with long disordered regions. J. Mol. Evol. 55, 104-110.
2. Dunker,A.K., Lawson,J.D., Brown,C.J., Williams,R.M., Romero,P., Oh,J.S., Oldfield,C.J., Campen,A.M., Ratliff,C.M., Hipps,K.W., Ausio,J., Nissen,M.S., Reeves,R., Kang,C., Kissinger,C.R., Bailey,R.W., Griswold,M.D., Chiu,W., Garner,E.C. and Obradovic,Z. (2001) Intrinsically disordered protein. J. Mol. Graph. Model., 19, 26-59.
3. Dunker,A.K., Obradovic,Z., Romero,P., Garner,E.C. and Brown,C.J. (2000) Intrinsic protein disorder in complete genomes. Genome Inform. Ser. Workshop Genome Inform., 11, 161-171.
4. Eisenberg,E. and Levanon,E.Y. (2003) Human housekeeping genes are compact. Trends Genet., 19, 362-365.
5. Iakoucheva,L.M., Brown,C.J., Lawson,J.D., Obradovic,Z. and Dunker,A.K. (2002) Intrinsic disorder in cell-signaling and cancer-associated proteins. J. Mol. Biol., 323, 573-584.
6. Kyte,J. and Doolittle,R.F. (1982) A simple method for displaying the hydropathic character of a protein. J. Mol. Biol., 157, 105-132.
7. Li,X., Romero,P., Rani,M., Dunker,A.K. and Obradovic,Z. (1999) Predicting protein disorder for N-, C-, and internal regions. Genome Inform. Ser. Workshop Genome Inform., 10, 30-40.
8. Liu,J., Tan,H. and Rost,B. (2002) Loopy proteins appear conserved in evolution. J. Mol. Biol., 322, 53-64.
9. Longhi,S., Receveur-Brechot,V., Karlin,D., Johansson,K., Darbon,H., Bhella,D., Yeo,R., Finet,S. and Canard,B. (2003) The C-terminal domain of the measles virus nucleoprotein is intrinsically disordered and folds upon binding to the C-terminal moiety of the phosphoprotein. J. Biol. Chem., 278, 18638-18648.
10. Romero,P., Obradovic,Z. and Dunker,A.K. (1997) Sequence data analysis for long disordered regions prediction in the calcineurin family. Genome Inform. Ser. Workshop Genome Inform., 8, 110-124.
11. Romero,P., Obradovic,Z., Li,X., Garner,E.C., Brown,C.J. and Dunker,A.K. (2001) Sequence complexity of disordered protein. Proteins 42, 38-48.
12. Uversky,V.N. (2002) What does it mean to be natively unfolded? Eur. J. Biochem., 269, 2-12.
13. Uversky,V.N., Gillespie,J.R. and Fink,A.L. (2000) Why are "natively unfolded" proteins unstructured under physiologic conditions? Proteins, 41, 415-427.
14. Wright,P.E. and Dyson,H.J. (1999) Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm. J. Mol. Biol., 293, 321-331.
15. Zeev-Ben-Mordehai,T., Rydberg,E.H., Solomon,A., Toker,L., Auld,V.J., Silman,J., Botti,S. and Sussman,J.L. (2003) The intracellular domain of the Drosophila cholinesterase-like neural adhesion protein, gliotactin, is natively unfolded. Proteins, 53, 758-767.
16. Zhang,L. and Li,W.H. (2004) Mammalian housekeeping genes evolve more slowly than tissue-specific genes. Mol. Biol. Evol., 21, 236-239.