Lack of allelic association of dopamine D1 and D2 (TaqIA) receptor gene polymorphisms with reduced dopaminergic sensitivity in alcoholism

Alcoholism: Clinical and Experimental Research

Volumn 20, Issue 6, 1996, Pages 1109-1113

  Heinz, Andreas ^a,b   Sander, Thomas ^a   Harms, Helmut ^a   Finckh, Ulrich ^a   Kuhn, Silke ^a   Dufeu, Peter ^a   Dettling, Michael ^a   Gräf, Klaus ^a   Rolfs, Arndt ^a   Rommelspacher, Hans ^a   Schmidt, Lutz G ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Association; DRD1; DRD2; Genetics; Relapse

Indexed keywords

ALCOHOL; APOMORPHINE; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; GROWTH HORMONE;

ADULT; ALCOHOLISM; ALLELISM; ARTICLE; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RECEPTOR GENE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; TREATMENT OUTCOME;

EID: 10144262631     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.1996.tb01954.x     Document Type: Article

References (33)

1. Koob GF: Drug abuse: Anatomy, pharmacology and function of reward pathways. Trends Pharmacol Sci 13:177-184, 1992
2. Nestler EJ, Hope BT, Widnell KL: Drug addiction: A model for the molecular basis of neural plasticity. Neuron 11:995-1006, 1993
3. Mereu G, Fadda F, Cessa GL: Ethanol stimulates the firing rate of nigral dopaminergic neurons in unanesthetizd rats. Brain Res 292:63-69, 1984
4. Imperato A, Di Chiara G: Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol. J Pharmacol Exp Ther 239:219-228, 1986
5. Weiss F, Lorang MT, Bloom FE, Koob GF: Oral alcohol selfadministration stimulates dopamine release in the rat nucleus accumbens: Genetic and motivational determinants. J Pharmacol Exp Ther 267:250-258, 1993
6. McBride WJ, Murphy JM: Serotonin and dopamine systems regulating alcohol intake, Alcohol (Suppl. 1):411-416, 1991
7. Blum K, Noble EP, Sheridan PJ, Montgomery A, Ritchie T, Jagadeeswaran P, Nogami H, Briggs AH, Cohn JB: Allelic association of human dopamine D2 receptor gene in alcoholism. JAMA 263:2055-2060, 1990
8. 2 dopamine receptor gene: A review of association studies in alcoholism. Behav Genet 23:119-129, 1993
9. Pato CN, Macciardi F, Pato MT, Verga M, Kennedy JL: Review of the putative association of dopamine D2 receptor and alcoholism: A meta-analysis. Am J Med Genet (Neuropsychiatr Genet) 48:78-82, 1993
10. Nobel EP, Blum K, Ritchie T, Montgomery A, Sheridan PJ: Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism. Arch Gen Psychiatry 48:648-655, 1992
11. 2 dopamine receptor Al allele. Nat Med 1:337-341, 1995
12. 2 dopamine receptor binding characteristics in vivo in patients with alcohol-dependence. Psychopharmacology 116:285-290, 1994
13. Balldin JI, Berggren UC, Lindstedt G: Neuroendocrine evidence for reduced dopamine receptor sensitivity in alcoholism. Alcohol Clin Exp Res 16:71-74, 1992
14. Balldin J, Berggren U, Lindstedt G, Sundkler A. Further neuroendocrine evidence for reduced D2 dopamine receptor function in alcoholism. Drug Alcohol Depend 32:159-162, 1993
15. Heinz A, Dettling M, Kuhn S, Dufeu P, Gräf KJ, Kürten I, Rommeispacher H, Schmidt LG: Blunted growth hormone response is associated with early relapse in alcohol-dependent patients. Alcohol Exp Clin Res 19:61-65, 1995
16. Fabbrini G, Braun A, Mouradian M, Tamminga CA, Chase TN: Dopamine D-1 receptor agonist stimulation of prolactin secretion in man, J Neural Transm (Gen Sect) 71:159-163, 1988
17. Wong AO, Chang JP, Peter RE: Dopamine stimulates growth hormone release from the pituitary of goldfish, Carassius aratus, through the dopamjne D1 receptors. Endocrinology 130:1201-1210, 1992
18. World Health Organization: International classification of diseases. 10th revision, Clinical descriptions and diagnostic guidelines. World Health Organization, Geneva, 1992
19. Robins LN, Wing J, Wittchen HU: The composite International Diagnostic Interview: An epidemiological instrument suitable for use in conjugation with different diagnostic systems and in different cultures. Arch Gen Psychiatry 45:1069-1077, 1988
20. Heinz A, Lichtenberg-Kraag B, Sällström Baum S, Gräf KJ, Krüger F, Dettling M, Rommelspacher H: Evidence for prolonged recovery of dopaminergic transmission after detoxification in alcoholics with poor treatment outcome. J Neural Transm (Gen Sect) 102:149-157, 1995
21. Sander T, Harms H, Podschus J, Finckh U, Nickel B, Rolfs A, Rommelspacher H, Schmidt LG: Dopamine D1, D2 and D3 receptor genes JB alcohol dependence. Psychiatr Genet (in press)
22. Sullivan JT, Sykora K, Schneiderman J, Narkanjo CA, Sellers EM: Assessment of alcohol withdrawal: The revised Clinical Institute Withdrawal Assessment for Alcohol scale (CIWA-Ar). Br J Addict 84:1353-1357, 1989
23. Miller SA, Dykes D, Plesky HF: A simple salting out procedure for extracting DMA from human nucleated cells. Nucleic Acids Res 16:1215, 1988
24. Cichon S, Nöthen MM, Erdmann J, Propping P: Detection of four polymorphic sites in the human D1 receptor gene (DRD1). Hum Mol Genet 3:209, 1994
25. Grandy DK, Zhang Y, Civelli O: PCR detection of the Toq A. RFLP at the DRD2 locus. Hum Mol Genet 2:2197;1993
26. SAS Institute Inc: SAS/STAT™ User's Guide, Release 6.03 Edition. Cary, NC, SAS Institute, 1988
27. Dettling M, Heinz A, Dufeu P, Rommelspacher H, Gräf KJ, Schmidt LG: Dopaminergic responsivity in alcoholism - trait, state or residual marker? Am J Psychiatry 152:3317-1321, 1995
28. 1 receptor gene in 131 schizophrenics and eight alcoholics: Identification of polymorphisms but lack of functionally significant sequence changes. Am J Med Genet (Neuropsychiatr Genet) 60:165-171, 1995
29. Falk CT, Rubenstein P: Haplotype relative risks: An easy reliable way to construct proper control sample for risk calculations. Ann Hum Genet 51:227-233, 1987
30. 2-receptor DNA polymorphism ruled out in 45 alcoholics. Am J Hum Genet 49:203, 1991
31. Goldman D, Brown GL, Albaugh B, Robin R, Goodson S, Trunzo M, Akhtar L, Lucas-Derse S, Long J, Linnoila M, Dean M: DRD2 dopamine receptor genotype, linkage disequilibrium, and alcoholism in American Indians and other populations. Alcohol Clin Exp Res 17:199-204, 1993
32. 2-receptor gene polymorphisms in Scandinavian chronic alcoholics. Eur Arch Psychiatry Clin Neurosci 244:26-32, 1994
33. 2 receptor gene in alcoholism or schizophrenia. Analysis using denaturing gradient gel electrophoresis. JAMA 271:204-208, 1994