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Volumn 39, Issue 17, 1996, Pages 3343-3356

New low-density lipoprotein receptor upregulators acting via a novel mechanism

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYCHOLESTEROL; BENZAMIDE DERIVATIVE; CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; MEVINOLIN; RPR 102359; UNCLASSIFIED DRUG;

EID: 10144262565     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960153q     Document Type: Article
Times cited : (10)

References (25)
  • 1
    • 0017354135 scopus 로고
    • The low-density lipoprotein pathway and its relation to atherosclerosis
    • Snell, E. E., Boyer, P. D., Meister, A., Richardson, C. C., Eds.; Annual Reviews Inc.: CA
    • Goldstein, J. L.; Brown, M. S. The low-density lipoprotein pathway and its relation to atherosclerosis. In Annual Review in Biochemistry; Snell, E. E., Boyer, P. D., Meister, A., Richardson, C. C., Eds.; Annual Reviews Inc.: CA, 1977; Vol. 46, pp 897-903.
    • (1977) Annual Review in Biochemistry , vol.46 , pp. 897-903
    • Goldstein, J.L.1    Brown, M.S.2
  • 2
    • 0022549920 scopus 로고
    • A receptor-mediated pathway for cholesterol homeostasis
    • Goldstein, J. L.; Brown, M. S. A receptor-mediated pathway for cholesterol homeostasis. Science 1986, 232, 34-47.
    • (1986) Science , vol.232 , pp. 34-47
    • Goldstein, J.L.1    Brown, M.S.2
  • 3
    • 0021717457 scopus 로고
    • Liver transplantation to provide Low-Density-Lipoprotein receptors and lower plasma cholesterol in a child with homozygous familial hypercholesterolemia
    • Bilheimer, D. W.; Goldstein, J. L.; Grundy, T. E.; Startz, T. E.; Brown, M. S. Liver transplantation to provide Low-Density-Lipoprotein receptors and lower plasma cholesterol in a child with homozygous familial hypercholesterolemia. N. Engl. J. Med. 1984, 311, 1658-1664.
    • (1984) N. Engl. J. Med. , vol.311 , pp. 1658-1664
    • Bilheimer, D.W.1    Goldstein, J.L.2    Grundy, T.E.3    Startz, T.E.4    Brown, M.S.5
  • 4
    • 0025120211 scopus 로고
    • Regulation of the mevalonate pathway
    • Goldstein, J. L.; Brown, M. S. Regulation of the mevalonate pathway. Nature 1990, 343, 425-430.
    • (1990) Nature , vol.343 , pp. 425-430
    • Goldstein, J.L.1    Brown, M.S.2
  • 5
    • 0028011118 scopus 로고
    • Ketoconazole and 25-hydroxycholesterol produce reciprocal changes in the rate of transcription of the human LDL receptor gene
    • (a) Ellsworth, J. L.; Carlstrom, A. J.; Deikman, J. Ketoconazole and 25-hydroxycholesterol produce reciprocal changes in the rate of transcription of the human LDL receptor gene. Biochem. Biophys. Acta 1994, 1210, 321-328.
    • (1994) Biochem. Biophys. Acta , vol.1210 , pp. 321-328
    • Ellsworth, J.L.1    Carlstrom, A.J.2    Deikman, J.3
  • 6
    • 0023865658 scopus 로고
    • Cholesterol metabolism during ketoconazole treatment in man
    • (b) Miettinen, T. A. Cholesterol metabolism during ketoconazole treatment in man. J. Lipid Res. 1988, 29, 43-51.
    • (1988) J. Lipid Res. , vol.29 , pp. 43-51
    • Miettinen, T.A.1
  • 7
    • 0023940003 scopus 로고
    • Hormonal regulation of low-density lipoprotein (LDL) activity in human Hep G2 cells. Insulin increases LDL receptors activity and diminishes its suppression by exogenous LDL
    • Wade, D. P.; Knight, B. L.; Soutar, A. K. Hormonal regulation of low-density lipoprotein (LDL) activity in human Hep G2 cells. Insulin increases LDL receptors activity and diminishes its suppression by exogenous LDL. Eur. J. Biochem. 1988, 174 (1), 213-218.
    • (1988) Eur. J. Biochem. , vol.174 , Issue.1 , pp. 213-218
    • Wade, D.P.1    Knight, B.L.2    Soutar, A.K.3
  • 8
    • 0027333561 scopus 로고
    • Vascular transcellular signaling
    • Marcus, A. J.; Hajjar, D. P. Vascular transcellular signaling. J. Lipid Res. 1993, 34, 2017-2032.
    • (1993) J. Lipid Res. , vol.34 , pp. 2017-2032
    • Marcus, A.J.1    Hajjar, D.P.2
  • 9
    • 0026512161 scopus 로고
    • Lysosome Inhibitors Enhance The Ability of Cyclic AMP-Elevating Agents to Induce the LDL Receptor in Human Vascular Smooth Muscle Cells
    • Middleton, B. Lysosome Inhibitors Enhance The Ability of Cyclic AMP-Elevating Agents to Induce the LDL Receptor in Human Vascular Smooth Muscle Cells. Biochem. Biophys. Res. Commun. 1992, 782, 830-835.
    • (1992) Biochem. Biophys. Res. Commun. , vol.782 , pp. 830-835
    • Middleton, B.1
  • 10
    • 0019304294 scopus 로고
    • Inhibitors of sterol synthesis. Hypercholesterolemic action of dietary 9α-fluoro-5α-cholest-8(14)-en-3β-ol-15-one
    • (a) Schroepfer, J. G.; Walker, V.; Parish, E. J.; Kisic, A. Inhibitors of sterol synthesis. Hypercholesterolemic action of dietary 9α-fluoro-5α-cholest-8(14)-en-3β-ol-15-one. Biochem. Biophys. Res. Commun. 1980, 93, 813.
    • (1980) Biochem. Biophys. Res. Commun. , vol.93 , pp. 813
    • Schroepfer, J.G.1    Walker, V.2    Parish, E.J.3    Kisic, A.4
  • 12
    • 0022257407 scopus 로고
    • Hypolidemic effects of dietary 7-oxo-24,25-dihydrolanosterol
    • (c) Sonoda, Y.; Sato, Y. Hypolidemic effects of dietary 7-oxo-24,25-dihydrolanosterol. J. Pharmacobio-Dyn. 1985, 8, 518-524.
    • (1985) J. Pharmacobio-Dyn. , vol.8 , pp. 518-524
    • Sonoda, Y.1    Sato, Y.2
  • 13
    • 0022905095 scopus 로고
    • Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol biosynthesis by oxylanosterols
    • (d) Panini, S. R.; Sexton, R. C.; Gupta, A. K.; Parish, E. J.; Chitrakorn, S.; Rudney, H. Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol biosynthesis by oxylanosterols. J. Lipid Res. 1986, 27, 1190-1204.
    • (1986) J. Lipid Res. , vol.27 , pp. 1190-1204
    • Panini, S.R.1    Sexton, R.C.2    Gupta, A.K.3    Parish, E.J.4    Chitrakorn, S.5    Rudney, H.6
  • 14
    • 0023597909 scopus 로고
    • Inhibitors of sterol synthesis. Effect of dietary 5α-cholest-8(14)-en-3β-ol-15-one on ACAT activity of jejunal microsomes of the rat
    • and references cited therein
    • (e) Needleman, D. H.; Strong, K.; Stemke, K. A.; Brabson, J. S.; Kisic, A.; Schroepfer, G. J. Inhibitors of sterol synthesis. Effect of dietary 5α-cholest-8(14)-en-3β-ol-15-one on ACAT activity of jejunal microsomes of the rat. Biochem. Biophys. Res. Commun. 1987,148, 920-925 and references cited therein.
    • (1987) Biochem. Biophys. Res. Commun. , vol.148 , pp. 920-925
    • Needleman, D.H.1    Strong, K.2    Stemke, K.A.3    Brabson, J.S.4    Kisic, A.5    Schroepfer, G.J.6
  • 19
    • 0027991818 scopus 로고
    • Design and synthesis of seco-oxysterol analogs as potential inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase gene transcription
    • (j) Larsen, S. D.; Spilman, C. H.; Yagi, Y.; Dinh, D. M.; Hart, K. L.; Hess, G. F. Design and synthesis of seco-oxysterol analogs as potential inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase gene transcription. J. Med. Chem. 1994, 37, 2343-2351.
    • (1994) J. Med. Chem. , vol.37 , pp. 2343-2351
    • Larsen, S.D.1    Spilman, C.H.2    Yagi, Y.3    Dinh, D.M.4    Hart, K.L.5    Hess, G.F.6
  • 20
    • 0021747172 scopus 로고
    • Correlation between oxysterol binding to a cytosolic binding protein and potency in the repression of hyroxymethylglutaryl coenzyme A reductase
    • Taylor, F. R.; Saucier, S. E.; Shown, E. P.; Parish, E. J.; Kandutsch, A. A. Correlation between oxysterol binding to a cytosolic binding protein and potency in the repression of hyroxymethylglutaryl coenzyme A reductase. J. Biol. Chem. 1984, 259, 12382-12387.
    • (1984) J. Biol. Chem. , vol.259 , pp. 12382-12387
    • Taylor, F.R.1    Saucier, S.E.2    Shown, E.P.3    Parish, E.J.4    Kandutsch, A.A.5
  • 23
    • 10144237003 scopus 로고    scopus 로고
    • Unpublished results
    • Bowyer, D. E. Unpublished results.
    • Bowyer, D.E.1
  • 24
    • 10144233275 scopus 로고
    • RPR102359 upregulates LDL receptors in a cultured human hepatocyte cell line by a sterol-independent mechanism
    • Brown, T. J.; White, A.; Lloyd, J.; Vicker, N.; Lockey, P. RPR102359 upregulates LDL receptors in a cultured human hepatocyte cell line by a sterol-independent mechanism. Atherosclerosis 1994, 109, 113-114.
    • (1994) Atherosclerosis , vol.109 , pp. 113-114
    • Brown, T.J.1    White, A.2    Lloyd, J.3    Vicker, N.4    Lockey, P.5
  • 25
    • 33845280859 scopus 로고
    • Molecular Armatures. Synthesis and Structure of Troger's Base Analogues Derived from 4-,2,4-,3,4 and 2,4,5-Substituted Aniline Derivatives
    • Sucholeiki, I.; Lynch, V.; Phan, L.; Wilcox, C. S. Molecular Armatures. Synthesis and Structure of Troger's Base Analogues Derived from 4-,2,4-,3,4 and 2,4,5-Substituted Aniline Derivatives. J. Org. Chem. 1988, 53, 98-104.
    • (1988) J. Org. Chem. , vol.53 , pp. 98-104
    • Sucholeiki, I.1    Lynch, V.2    Phan, L.3    Wilcox, C.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.