Behavioral and neurophysiological effects of CNS expression of cytokines in transgenic mice

Advances in Experimental Medicine and Biology

Volumn 402, Issue , 1996, Pages 199-206

  Gold, Lisa H ^a   Heyser, Charles J ^a   Roberts, Amanda J ^a   Henriksen, Steven J ^a   Steffensen, Scott C ^a   Siggins, George R ^a   Bellinger, Frederick P ^a   Chiang, Chi Shiun ^a   Powell, Henry C ^b   Masliah, Eliezer ^b   Campbell, Lain L ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 6;

ANIMAL MODEL; BEHAVIOR; CENTRAL NERVOUS SYSTEM DISEASE; CONFERENCE PAPER; MOUSE; NEUROPATHOLOGY; NEUROPHYSIOLOGY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; TRANSGENIC MOUSE;

ANIMALIA; MUS MUSCULUS;

EID: 10144254413     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4613-0407-4_26     Document Type: Conference Paper

References (10)

1. Campbell, I.L., Abraham, C.R., Masliah, E., Kemper. P., Inglis, J.D., Oldstone, M.B.A. and Mucke, L. Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6. Proc. Natl. Acad. Sci. USA. 90:10061-10065, 1993.
2. Chiang, C-S., Stalder, A.S., Samimi, A. and Campbell, LL.. Reactive gliosis as a consequence of IL-6 expression in the brain. Studies in transgenic mice. Dev. Neurosci., 16:212-221, 1994.
3. Campbell, I. L. Neuropathogenic actions of cytokines assessed in transgenic mice. Int. J. Dev. Neurosci., 13:275-284, 1995.
4. Chiang, C-S., Powell, H.C., Gold, L., Samimi, A., and Campbell, I.L. Macrophage/microglial-mediated primary demyelination and motor disease induced by the CNS production of interleukin-3 in transgenic mice. J. Clin. Invest. in press, 1996.
5. Gold. L.H., Heyser, C.J. and Campbell. I.L. Progressive cognitive impairment in discriminated avoidance performance in GFAP-IL6 transgenic mice. Neurosci. Abstr. 21:2110, 1995.
6. Gold, L.H., Brot, M.D., Polis, L. Schroeder, R.S., Tishon, A., de la Torre, J-C., Oldstone, M.B.A. and Koob, G.F. Behavioral effects of persistent lymphocytic choriomeningitis virus infection in mice. Behav. Neural Biol., 62:100-109, 1994.
7. Steffensen, S.C., Campbell, I.L. and Henriksen, S.J. Site-specific hippocampal pathophysiology due to cerebral overexpression of interleukin-6 in transgenic mice. Brain Res., 652:149-153, 1994.
8. Bellinger, F.P., Madamba, S.G., Campbell, I.L. and Siggins, G.R. Reduced long-term potentiation in the dentate gyms of transgenic mice with cerebral overexpression of interleukin-6. Neurosci. Lett., 198:95-98, 1995.
9. Jones, B.J. and Roberts, D.J. The quantitative measurement of motor inco-ordination in naive mice using an accelerating rota-rod. J Pharm Pharmac 20: 302-304, 1968.
10. Laffan, E.W., Lisciotto, C.A., Gapp, D.A. and Weldon, D.A. Development of rotorod performance in normal and congenitally hypothyroid mutant mice. Beh Neural Biol 52: 411-416, 1989.