Psychosocial impact of testing (by linkage) for the CRCA1 breast cancer gene: An investigation of two families in the research setting

Psycho-Oncology

Volumn 5, Issue 3, 1996, Pages 233-239

  Watson, M ^a,e   Lloyd, S M ^a   Eeles, R ^a   Ponder, B ^c   Easton, D ^a   Seal, S ^a   Averill, D ^a   Daly, P ^d   Ormiston, W ^d   Murday, V ^b  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b ST GEORGE S HOSPITAL   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d ST JAMES S HOSPITAL   (Ireland)

^e ROYAL MARSDEN HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BREAST CANCER; CANCER SUSCEPTIBILITY; CLINICAL ARTICLE; CONTROLLED STUDY; FAMILY STUDY; FEMALE; HETEROZYGOTE DETECTION; HUMAN; MALE; ONCOGENE; PSYCHOSOCIAL ENVIRONMENT;

EID: 10144250936     PISSN: 10579249     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1611(199609)5:3<233::AID-PON238>3.0.CO;2-T     Document Type: Article

References (20)

1. Claus, E. B., Risch, N. J. and Thompson, W. D. (1991) Genetic analysis of breast cancer in the cancer and steroid hormone study. Am. J. Hum. Genet. 48, 232-42.
2. Claus, E. B., Risch, N. and Thompson, W. D. (1990) Age of onset as an indicator of familial risk of breast cancer. Am. J. Epidemiol, 131, 961-972.
3. Collins, F. S. (1996) BRCA1 - Lots of mutations, lots of dilemmas. The New England J. Med., 334, 186-188.
4. Easton, D. F. and Peto, J. (1990) The contribution of inherited predisposition to cancer incidence. Cancer Surveys, 9, 395-415.
5. Easton, D. F., Bishop, D. T, Ford, D., Crockford, G. P. and the Breast Cancer Linkage Consortium. (1992) Genetic linkage analysis in familial breast and ovarian cancer: Results from 214 families. Am. J. Hum. Genet. 52, 678-701.
6. Easton, D. F., Ford, D., Bishop, D. T. and the Breast Cancer Linkage Consortium. (1995) Breast and ovarian cancer incidence in BRCA1-mutation carriers. Am. J. Hum. Genet. 56, 265-271.
7. Ford, D., Easton, D. F., Bishop, D. T., Narod, S. A. and Goldgar, D. E. (1994) Risks of cancer in BRCA1 mutation carriers. Lancet, 343, 692-495.
8. Ford, D., Easton, D. and Peto, J. (1995) Estimates of the gene frequency of BRCA1 and its contribution to breast and ovarian cancer incidence. Am. J. Hum. Genet., 57, 1457-1462.
9. Goldberg, D. and Williams, P. (1988) A User's Guide to the General Health Questionnaire. NFER-Nelson, Windsor, UK.
10. Hall, J. M., Lee, M. K., Newman, B., Morrow, J., Anderson, L. A., Huey, B. and King, M.-C. (1990) Linkage analysis of early onset familial breast cancer to chromosome 17q21. Science, 250, 1684-1689.
11. Horowitz, M., Wilner, N. and Alvarez, W. (1979) Impact of events scale: a measure of subjective stress. Psychosom. Med. 41, 209-218.
12. Kash, K. M., Holland, J. C., Halper, M. S. and Miller, D. G. (1992) Psychological distress and surveillance behaviours of women with a family history of breast cancer, J. Natl. Cancer Inst. 84, 24-30.
13. King, M.-C., Rowell, S. and Love, S. M. (1993) Inherited breast and ovarian cancer. What are the risks? What are the choices? JAMA, 269 (15), 1975-1980.
14. Lloyd, S., Watson, M., Waites, B., Meyer, L., Eeles, R., Ebbs, S. and Tylee, A. (1996) Familial breast cancer: A controlled study of risk perception, psychological morbidity and health beliefs in women attending for genetic counselling. Br. J. Cancer, in press.
15. Lynch, H. T., Albano, W. A., Heieck, J. J. et al. (1984) Genetics, biomarkers an control of breast cancer: A review. Cancer Genet. Cytogenet, 13, 43-92.
16. Morris, T. and Greer, S. (1982) Psychological characteristics of women electing to attend a breast screening clinic. Clinical Oncology, 8, 113-119.
17. Miki, Y., Swensen, J., Shattuck-Eidens, D., Futreal, A., Harshman, K., Tavtigian, S., et al. (1994) A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266, 66-71.
18. Narod, S. A., Feunteun, J., Lynch, H. T., Watson, P., Conway, T., Lynch, J. and Lenoir, G. M. (1991) Familial breast-ovarian cancer locus on chromosome 17q12-23. Lancet, 338, 82-83.
19. Spielberger, C. D. (1983) State-Trait Anxiety Inventory for Adults. Distributed by Mind Garden, Palo Alto, California. Manual for the State-Trait Anxiety Inventory, STAI. Consulting Psychologists' Press, Palo Alto.
20. Wooster, R., Bignell, G., Lancaster, J., Swift, S., Seal, S., Mangion, J, et al. (1995) Identification of the breast cancer susceptibility gene BRCA2. Nature, 378, 789-792.