A novel parallel shaken bioreactor system for continuous operation

Biotechnology Progress

Volumn 20, Issue 6, 2004, Pages 1718-1724

  Akgün, Ali ^a   Maier, Bernd ^a,b   Preis, Diana ^a   Roth, Birthe ^a,c   Klingelhöfer, Renata ^a   Büchs, Jochen ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b MERCK KGAA   (Germany)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMASS; CELL CULTURE; FERMENTATION; GROWTH KINETICS; MICROORGANISMS; PRODUCT DEVELOPMENT; YEAST;

CIRCULATING MOTION; DILUTION; PRODUCT FORMATION; SHAKEN CULTURE VESSEL;

BIOREACTORS;

ALCOHOL; GLUCOSE;

ARTICLE; BIOREACTOR; CELL PROLIFERATION; CULTURE TECHNIQUE; EQUIPMENT; EQUIPMENT DESIGN; EVALUATION; FEASIBILITY STUDY; FLOW KINETICS; INSTRUMENTATION; METABOLISM; METHODOLOGY; MICROBIOLOGY; PHYSIOLOGY; PILOT STUDY; SACCHAROMYCES CEREVISIAE; STIMULATION;

BIOREACTORS; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; ETHANOL; FEASIBILITY STUDIES; GLUCOSE; PHYSICAL STIMULATION; PILOT PROJECTS; RHEOLOGY; SACCHAROMYCES CEREVISIAE;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 10044290666     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp034289a     Document Type: Article

References (23)

1. Monod, J. Continuous culture technique. Theory and applications. Ann. Inst. Pasteur 1950, 79, 390-410.
2. Novick, A.; Szilard, L. Experiments with the chemostat on the spontaneous mutations of bacteria. Proc. Natl. Acad. Sci. U.S.A. 1950, 36, 708-719.
3. Herbert, D.; Elsworth, R.; Telling, R. C. The continuous culture of bacteria, a theoretical and experimental study. J. Gen. Microbiol. 1956, 14, 601.
4. Herbert, D. A Theoretical analysis of continuous culture systems. In Continuous Culture of Microorganisms; Publishing House of the Czechoslovak Academy of Science: Prague, 1960; pp 21-53.
5. Moser, H. The Dynamics of Bacterial Populations Maintained in the Chemostat; Carnegie Institution Publication No. 614, Carnegie Institution: Washington, 1958.
6. Malek, I. Development and further perspectives of the continuous-flow method of cultivation of microorganisms. In Continuous Culture of Microorganisms; Publishing House of the Czechoslovak Academy of Science: Prague, 1960; pp 3-20.
7. Malek, I.; Fencl Z. Theoretical and Methodological Basis of Continuous Culture of Microorganisms; Academic Press: New York, 1966.
8. Kuhn, H.; Friederich, U.; Fiechter, A. Defined minimal medium for a thermophilic Bacillus sp. developed by a chemostat pulse and shift technique. Eur. J. Appl. Microbiol. 1979, 6, 341-349.
9. Goldberg, I.; Er-Al, Z. The chemostat-an efficient technique for medium optimization. Proc. Biochem 1981, 16, 2-8.
10. Villadsen, J.; Nielsen, J. Modelling of fermentation kinetics. Eur. Congr. Biotechnol. 1990, 1, 259-266.
11. Sipkema, E. M.; De Koning, W.; Ganzeveld, K. J.; Janssen, D. B.; Beenackers, A. Experimental pulse technique for microbial kinetics in continuous culture. J. Biotechnol. 1998, 64, 159-176.
12. Fiechter, A.; Meiners, M.; Moser, A. Biologische Regulation und Prozessführung. Handbuch der Biotechnologie, 4th ed.; Oldenbourg Verlag: München, Wien, 1994; pp 313-372.
13. Fiechter, A.; Fuhrmann, G. F.; Käppeli, O. Regulation of glucose metabolism in growing yeast cells. Adv. Microb. Physiol. 1981, 22, 123-183.
14. Zhang, J.; Greasham, R. Chemically defined media for commercial fermentations. Appl. Microbiol. Biotechnol. 1999, 51, 407-421.
15. Paalme, T.; Kahru, A.; Elken, R.; Vanatalu, K.; Tiisma, K.; Vilu, R. The computer-controlled continuous culture of Escherichia coli with smooth change of dilution rate (A-stat). J. Microbiol. Methods 1995, 24, 145-153.
16. Büchs, J. Introduction to advantages and problems of shaken cultures. Biochem. Eng. J. 2001, 7 (2), 91-98.
17. Büchs, J.; Maier, U.; Lotter, S. Calculation of the liquid distribution and mass and momentum transfer area in shake flasks on rotary shakers at waterlike viscosities. Unpublished work, 2004.
18. Maier, U.; Losen, M.; Büchs, J. Advances in understanding and modelling the gas-liquid mass transfer in shaking flasks, Biochem. Eng. J. 2004, 7 (3), 155-168.
19. Petrik, M.; Käppeli, O.; Fiechter, A. An expanded concept for the glucose effect in the yeast Saccharomyces uvarum: involvement of short- and long-term regulation. J. Gen. Microbiol. 1983, 129 (1), 43-49.
20. Sonnleitner, B.; Käppeli, O. Growth of Saccharomyces cerevisiae is controlled by its limited respiratory capacity: formulation and verification of a hypothesis. Biotechnol. Bioeng. 1986, 28 (6), 927-937.
21. Postma, E.; Verduyn, C.; Scheffers, W. A.; Van Dijken, J. P. Enzymic analysis of the crabtree effect in glucose-limited chemostat cultures of Saccharomyces cerevisiae. Appl. Environ. Microbiol. 1989, 55 (2), 468-477.
22. Pham, H, T. B.; Larsson, G.; Enfors, S.-O. Modelling of aerobic growth of Saccharomyces cerevisiae in a pH-auxostat. Bioprocess Eng. 1999, 20 (6), 537-544.
23. Sonderegger, M.; Sauer, U. Evolutionary engineering of Saccharomyces cerevisiae for anaerobic growth on xylose. Appl. Environ. Microbiol. 2003, 69 (4), 1990-1998.