Butterbur Ze339 for the treatment of intermittent allergic rhinitis: Dose-dependent efficacy in a prospective, randomized, double-blind, placebo-controlled study

Archives of Otolaryngology - Head and Neck Surgery

Volumn 130, Issue 12, 2004, Pages 1381-1386

  Schapowal, Andreas ^a  

^a Allergy Clinic   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BUTTERVUR EXTRACT; PLACEBO; PLANT EXTRACT; UNCLASSIFIED DRUG; ZE 339;

ADULT; ALLERGIC RHINITIS; ALLERGY TEST; ARTICLE; CLINICAL GLOBAL IMPRESSION SCALE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG MEGADOSE; DRUG SAFETY; FEMALE; GASTROINTESTINAL SYMPTOM; HAY FEVER; HERBAL MEDICINE; HOT FLUSH; HUMAN; INFLUENZA; INTENTION TO TREAT ANALYSIS; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NAUSEA; PETASITES HYBRIDUS; PLANT; RANDOMIZED CONTROLLED TRIAL; RASH; SCORING SYSTEM; SKIN TEST; STATISTICAL ANALYSIS; SYMPTOMATOLOGY;

ADULT; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; PLANT EXTRACTS; PROSPECTIVE STUDIES; RHINITIS, ALLERGIC, PERENNIAL; RHINITIS, ALLERGIC, SEASONAL;

EID: 10044289390     PISSN: 08864470     EISSN: None     Source Type: Journal    
DOI: 10.1001/archotol.130.12.1381     Document Type: Article

References (21)

1. Bousquet J, Van Cauwenberge P, Khaltaev N; Aria Workshop Group, World Health Organization. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol. 2001;108(suppl):S147-S334.
2. Smolensky MH, Reinberg A, Labrecque G. Twenty-four hour pattern in symptom intensity of viral and allergic rhinitis: treatment implications. J Allergy Clin Immunol. 1995;95(pt 2):1084-1096.
3. Petasites hybridus. The Royal Horticultural Society Web site. 2001. Available at: http://www.rhs.org.uk. Accessed September 20, 2004.
4. Meier B, Meier-Liebi M. Drogenmonographie Petasites. In: Ḧansel R, Keller K, Rimpler H, Schneider G, eds. Hagers Handbuch der pharmazeutischen Praxis. 5th ed. Berlin, Germany: Springer Verlag; 1994.
5. Brune K, Bickel O, Peskar BA. Gastro-protective effects by extracts of Petasites hybridus: the role of inhibition of peptido-leukotriene synthesis. Planta Med. 1993;59:494-496.
6. Bickel D, Roder T, Bestmann HJ, Brune K. Identification and characterization of inhibitors of peptido-leukotriene-synthesis from Petasites hybridus. Planta Med. 1994;60:318-322.
7. Thomet OA, Wiesmann UN, Schapowal A, Bizer C, Simon HU. Role of petasin in the potential anti-inflammatory activity of a plant extract of Petasites hybridus. Biochem Pharmacol. 2001;61:1041-1047.
8. Schapowal A, Petasites Study Group. Randomised controlled trial of butterbur and cetirizine for treating seasonal allergic rhinitis. BMJ. 2002;324:144-146.
9. Antihistamines: hyposensitisation and allergic emergencies. In: Mehta DK, ed. British National Formulary. London, England: British Medical Association and Royal Pharmaceutical Society of Great Britain; 1998.
10. Steiner R, Hauk A, Tratz W, inventors. Verfahren zur Herstellung von Heilpflanzenextrakten (Petasites hybridus). European patent EP 1023079 B1. September 29, 2001.
11. Allergic rhinitis: clinical development programs for drug products. US Department of Health and Human Services, Food and Drug Administration Web site. April 2000. Available at: http://www.fda.gov/cder/guidance/2718dft.pdf. Accessed September 20, 2004.
12. pollenallergie.de. Available at: http://www.pollenallergie.de. Accessed September 22, 2004.
13. Bousquet J, Bullinger M, Fayol C, Marquis P, Valentin B, Burtin B. Assessment of quality of life in patients with perennial allergic rhinitis with the French version of the SF-36 Health Status Questionnaire. J Allergy Clin Immunol. 1994;94 (pt 1)182-188.
14. 028 CGI Clinical Global Impressions. In: Guy W, ed. ECDEU Assessment for Psychopharmacology. Rev ed. Rockville, Md: National Institute of Mental Health; 1976:217-222.
15. Abt K. Descriptive data analysis: a concept between confirmatory and exploratory data analysis. Methods Inf Med. 1987;26:77-88.
16. Wheatley D. LI 160, an extract of St John's wort, versus amitriptyline in mildly to moderately depressed outpatients: a controlled 6-week clinical trial. Pharmacopsychiatry. 1997;30(suppl 2):77-80.
17. Woelk H. Comparison of St John's wort and imipramine for treating depression: randomised controlled trial. BMJ. 2000;321:536-539.
18. Schellenberg R. Treatment for the premenstrual syndrome with agnus castus fruit extract: prospective, randomised, placebo controlled study. BMJ. 2001;322:134-137.
19. Thomet OA, Schapowal A, Heinisch IV, Wiesmann UN, Simon HU. Antiinflammatory activity of an extract of Petasites hybridus in allergic rhinitis. Int Immunopharmacol. 2002;2:997-1006.
20. Thomet OA, Simon HU. Petasins in the treatment of allergic diseases: results of preclinical and clinical studies. Int Arch Allergy Immunol. 2002;129:108-112.
21. Thomet OA, Wiesmann UN, Blaser K, Simon HU. Differential inhibition of inflammatory effector functions by petasin, isopetasin and neopetasin in human eosinophils. Clin Exp Allergy. 2001;31:1310-1320.