Successful development and scale-up of a palladium-catalysed amination process in the manufacture of ZM549865

Organic Process Research and Development

Volumn 8, Issue 6, 2004, Pages 925-930

  Robinson, Graham E ^a   Cunningham, Oliver R ^a   Dekhane, Mouloud ^a   McManus, Julie C ^a   O'Kearney McMullan, Anne ^a   Mirajkar, Abdurrazzaque M ^a   Mishra, Vikas ^a   Norton, Alison K ^a   Venugopalan, B ^a   Williams, Emyr G ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 BROMO 4 FLUOROPHENOL; ACETYLENEDICARBOXYLIC ACID DIMETHYL ESTER; ESTER DERIVATIVE; ETHYL 8 BROMO 6 FLUORO 4 OXO 4H 2 CHROMENE CARBOXYLATE; OXALIC ACID; PALLADIUM; PHENOL DERIVATIVE; SEROTONIN ANTAGONIST; UNCLASSIFIED DRUG; ZM 549865;

AMINATION; ARTICLE; CATALYSIS; CYCLIZATION; DRUG SYNTHESIS; HYDROLYSIS; POLYMERIZATION; REACTION ANALYSIS; REDUCTION;

EID: 10044288498     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op0499369     Document Type: Article

References (5)

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3. The Chemistry of Heterocyclic Compounds: Chromenes, Chromanones and Chromones; Ellis, G. P., Ed.; Wiley and Sons: New York, 1977; pp 572 and 972.
4. Bryan, J. D.; Goldberg, A. A.; Wragg, A. H. J. Chem. Soc., Abstr. 1960, 1279.
5. The Chemistry of Heterocyclic Compounds: Chromenes, Chromanones and Chromones; Ellis, G. P., Ed.; Wiley and Sons: New York, 1977; p 944.