Scale-up and safety evaluation of a sandmeyer reaction

Organic Process Research and Development

Volumn 8, Issue 6, 2004, Pages 1059-1064

  Nielsen, Martin Anker ^a   Nielsen, Michael Kim ^a   Pittelkow, Thomas ^a  

^a H LUNDBECK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO 5 TRIFLUOROMETHYLBENZONITRILE; BENZONITRILE; COPPER CYANIDE; COPPER DERIVATIVE; CYANIDE; SODIUM CYANIDE; UNCLASSIFIED DRUG;

ARTICLE; ENVIRONMENT; EVALUATION; EVAPORATION; REACTION TIME; SANDMEYER REACTION; SCALE UP;

EID: 10044280533     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op0498823     Document Type: Article

References (9)

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2. Urben, P. G. Bretherick's Handbook of Reactive Chemical Hazards, 6th ed.; Butterworth Heinemann: Oxford, 1999; Vol. 2, pp 96-97.
3. Anon.; Sichere Chemiearbeit 1993, 45, 8.
4. 6th International Symposium, Loss Prevention and Safety Promotion in the Process Industries, Oslo, Norway, June 19-22, 1989; Vol. 2, pp 37.11-37.15.
5. Schank, K., Patai, S., Eds. In The Chemistry of Diazonium and Diazo Groups; Part 2: Preparation of Diazonium Groups; Wiley and Sons: New York, 1978; pp 646-647.
6. Wulfman, D. S., Patai S., Eds. In The Chemistry of Diazonium and Diazo Groups; Part 2: Synthetic Applications of Diazonium Ions; Wiley and Sons: New York, 1978; pp 251.
7. Carey, F. A.; Sundberg R. J. Advanced Organic Chemistry, 3rd ed.; Plenum Press: New York, 1990; Part B, p 599.
8. No solvent was added in experiment 3: crude I was tapped from the bottom valve after stirring at 65°C for 2 h.
9. i).