Anxiety Levels and Neurosteroid Synthesis in the Brains of Prenatally Stressed Male Rats

Neuroscience and Behavioral Physiology

Volumn 33, Issue 9, 2003, Pages 899-903

  Ordyan, N E ^a   Pivina, S G ^a  

^a PAVLOV INSTITUTE OF PHYSIOLOGY   (Russian Federation)

Author keywords

5 reductase; Behavior; Neurosteroids; Prenatal stress

Indexed keywords

PROGESTERONE; STEROID 5ALPHA REDUCTASE;

ACUTE STRESS DISORDER; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; FRONTAL CORTEX; HIPPOCAMPUS; HYPOTHALAMUS; IMMOBILIZATION STRESS; MALE; MEDICAL ASSESSMENT; NONHUMAN; PRENATAL PERIOD; PROGESTERONE RELEASE; RAT; SPECIES COMPARISON; THIRD TRIMESTER PREGNANCY;

ANIMALS; ANXIETY; BEHAVIOR, ANIMAL; BRAIN; FEMALE; FRONTAL LOBE; HIPPOCAMPUS; HYPOTHALAMUS; IMMOBILIZATION; MALE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PROGESTERONE; RATS; RATS, WISTAR; STEROIDS; STRESS, PSYCHOLOGICAL; TESTOSTERONE 5-ALPHA-REDUCTASE;

EID: 0942299248     PISSN: 00970549     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1025952906715     Document Type: Article

References (27)

1. G. Derner, F. Geits, and V. Rode, "The significance of hormone-dependent brain development for the ontogenesis of animals and humans," in: Ontogenetic and Genetic-Evolutionary Aspects of the Neuroendocrine Regulation of Stress [in Russian], E. V. Naumenko and N. K. Popov (eds.), Nauka, Novosibirsk (1990).
2. I. N. Zaichenko, F. I. Proimina, and N. É. Ordyan, "Modification of sex steroid and anxiety levels by maternal stress," Zh. Vyssh. Nerv. Deyat., 49, No. 1, 106-112 (1999).
3. I. N. Zaichenko and N. É. Ordyan, "Maternal hormones in the formation of the psychophysiological status of offspring," in: Psychophysiological Bases of the Social Adaptation of Children [in Russian], A. S. Batuev, N. N. Sokolov, and L. V. Sokolov (eds.), St. Petersburg (1999), pp. 36-41.
4. V. I. Morozov, V. S. Chaikovskii, S. A. Priyatkin, V. A. Rogozhkin, and O. N. Savchenko, "Radioimmunological analysis of steroids - scientific and applied aspects," Fiziol Zh. SSSR, 74, No. 8, 473-476 (1988).
5. V. G. Shalyapina, I. N. Zaichenko, A. S. Batuev, and N. É. Ordyan, "Changes in the neuroendocrine regulation of adaptive behavior after stress in late prenatal ontogenesis," Ros. Fiziol. Zh. im. I. M. Sechenova, 87, No. 9, 1193-1201 (2001).
6. G. T. Shishkina and N. N. Dygalo, "Genes, hormones, and risk factors for the formation of the male phenotype," Usp. Fiziol. Nauk., 30, No. 3, 49-61 (1999).
7. M. L. Barbaccia, G. Roscetti, M. Travucchi, R. H. Purdy, M. C. Mostallino, A. Concas, and G. Biggino, "The effects of inhibitors of GABAergic transmission and stress on the brain and plasma allopregnanolone concentrations," Brit. J. Pharmacol., 120, 1582-1588 (1997).
8. M. Bicikova, L. Dibbelt, M. Hill, R. Hampl, and L. Starka, "Allopregnanolone in women with premenstrual syndrome," Horm. Metab. Res., 30, 227-230 (1998).
9. A receptors," J. Neuroendocrinol., 7, 171-177 (1995).
10. J. E. Booth, "Sexual differentiation of the brain," in: Oxford Reviews of Reproductive Biology, C. A. Finn (ed.), Clarendon Press, Oxford (1979), pp. 58-158.
11. E. Dong, K. Matsumoto, V. Uzunova, I. Sugaya, H. Takahata, H. Nomura, H. Watanabe, E. Coasta, and A. Guidotti, "Brain 5α-dehydroprogesterone and allopregnanolone synthesis in a mouse model of protracted social isolation," Proc. Natl. Acad. Sci. USA, 98, 2849-2854 (2001).
12. W. P. Eechaute, W. S. Dhoog, C. Q. Gao, P. Calders, R. Rubens, J. Weyne, and J. M. Kaufman, "Progesterone-transforming enzyme activity in the hypothalamus of the male rat," J. Steroid Biochem. Mol. Biol., 70, 159-167 (1999).
13. A. Galeeva and P. Ruohimaa, "Analysis of mouse plus-maze behaviour modulated by ovarian steroids," Behav. Brain Res., 119, 41-47 (2001).
14. L. R. Herrenkohl, "Prenatal stress disrupts reproductive behavior and physiology in offspring," Ann. N.Y. Acad. Sci., 474, 120-128 (1986).
15. C. Kinsley and B. Svare, "Genotype modulates prenatal stress effects on aggression in male and female mice," Behav. Neural. Biol., 47, 138-150 (1987).
16. 500 in rat brain, " Science (Washington DC), 237, 1212-1214 (1987).
17. R. Melcangi, F. Celotti, and L. Martini, "Progesterone 5α-reduction in neuronal and in different types of glial cell cultures. Type 1 and 2 astrocytes and oligodendrocytes," Brain Res., 639, 202-206 (1994).
18. S. H. Mellon, L. D. Griffin, and N. A. Compagnone, "Biosynthesis and action of neurosteroids," Brain Res. Brain Rev., 37, 3-12 (2001).
19. S. Mora, N. Dussaubat, and G. Diaz-Veliz, "Effects of the estrous cycle and ovarian hormones on behavioral indices of anxiety in female rats," Psychoneuroedocrinol., 21, 609-620 (1996).
20. A. G. Reznikov, N. D. Nosenko, and L. V. Tarasenko, "Prenatal stress and glucocorticoid effects on the developing gender-related brain," J. Steroid Biochem. Molec. Biol., 69, 109-115 (1999).
21. S. Segovia, A. Guillamon, M. C. R. del Cerro, E. Ortega, C. Peter-Laso, M. Rodriguez-Zafra, and C. Beyer, "The development of brain sex differences: a multisignaling process," Behav. Brain Res., 105, 69-80 (1999).
22. B. Stoffel-Wagner, S. Beyenburg, M. Watzka, I. Blumcke, J. Bauer, J. Schramm, F. Bidlingmaier, and C. E. Elger, "Expression of 5alpha-reductase and 3alpha-hydroxysteroid oxidoreductase in the hippocampus of patients with chronic temporal lobe epilepsy," Epilepsia, 41, 140-147 (2000).
23. A. Ströhle, E. Romeo, B. Herman, A. Pasini, G. Spaletta, F. Di Michele, F. Halsboer, and R. Ruprecht, "Concentrations of 3α-reduced neuroactive steroids and their precursors in plasma of patients with major and after clinical recovery," Biol. Psychiatry, 45, 274-277 (1999).
24. H. J. Stürenburg, U. Fries, and K. Kunze, "Glucocorticoids and anabolic/androgenic steroids inhibit the synthesis of GABAergic steroids in rat cortex," Neuropsychol., 35, 143-146 (1997).
25. K. Tsutsui, K. Ukena, M. Usui, H. Sakamoto, and M. Takase, "Novel brain function: biosynthesis and actions of neurosteroids in neurons," Neurosci. Res., 36, 261-273 (2000).
26. J. L. Ward, "Prenatal stress feminizes and demasculinizes the behavior of males," Science, 175, 82-84 (1972).
27. B. Zimmerberg and M. J. Farley, "Sex differences in anxiety behavior in rats: role of gonadal hormones," Physiol. Behav., 54, 1119-1124 (1993). 903