Mutation of Two Active-Site Residues Converts a Phosphatidylinositol-Specific Phospholipase C to a Glucose Phosphatase

Journal of the American Chemical Society

Volumn 126, Issue 4, 2004, Pages 1008-1009

  Feng, Jianwen ^a   Stieglitz, Kimberly ^a   Roberts, Mary F ^a  

^a BOSTON COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE 6 PHOSPHATASE; PHOSPHATIDYLINOSITOL; PHOSPHOLIPASE C;

ARTICLE; BINDING KINETICS; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME DEGRADATION; ENZYME SPECIFICITY; HYDROGEN BOND; MOLECULAR INTERACTION; REACTION ANALYSIS;

AMINO ACID SUBSTITUTION; BINDING SITES; GLUCOSE-6-PHOSPHATASE; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PHOSPHATIDYLINOSITOL DIACYLGLYCEROL-LYASE; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 0942298053     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja038529u     Document Type: Article

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