Combined exposure to m-xylene and ethanol: Oxidative stress in the rat liver

International Journal of Occupational Medicine and Environmental Health

Volumn 16, Issue 4, 2003, Pages 345-350

  Jajte, Jolanta ^a   Stetkiewicz, Jan ^b   Wrońska Nofer, Teresa ^b  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

^b NOFER INSTITUTE OF OCCUPATIONAL MEDICINE   (Poland)

Author keywords

Ethanol; Glutathione; Glutathione S transferase; Lipid peroxidation; m Xylene

Indexed keywords

ALCOHOL; GLUTATHIONE; GLUTATHIONE DERIVATIVE; GLUTATHIONE TRANSFERASE; META XYLENE; THIOL DERIVATIVE;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; LIPID PEROXIDATION; LIVER; LIVER MEMBRANE; LIVER TOXICITY; LONG TERM EXPOSURE; LYSOSOME MEMBRANE; MALE; MICROSOME MEMBRANE; NONHUMAN; OXIDATIVE STRESS; RAT; RAT STRAIN;

EID: 0942279580     PISSN: 12321087     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Bell GM, Shillaker RD, Padgham MDJ, Standring P. Xylenes. HSE Toxicity Rev 1992; 26: 166-70.
2. Zimmerman HJ. Effects of alcohol on other hepatotoxins. Alcohol Clin Exp Res 1986; 10: 3-15.
3. Elovaara R, Collan P, Pfaffli P, Vainio H. The combined toxicity of technical grade xylene and ethanol in the rat. Xenobiotica 1980; 10: 435-41.
4. Riihimaki V, Savolainen K, Pfaffli P, Pekari K, Sippel HW, Laine A. Metabolic interaction between m-xylene and ethanol. Arch. Toxicol 1982; 49(3-4): 253-63.
5. Wiśniewska-Knypl JM, Wrońska-Nofer T, Jajte J, Jedlińska U. The effect of combined exposures to ethanol and xylene on rat hepatic microsomal monooxygenase activities. Alcohol 1989; 6(5): 347-52.
6. Comporti M. Biology of disease. Lipid peroxidation and cellular damage in toxic liver injury. Lab Invest 1985; 53: 599-650.
7. Shaw S, Jayatilleke E, Lieber CS. Lipid peroxidation as a mechanism of alcoholic liver injury: role of iron mobilization and microsomal induction. Alcohol 1988; 5: 135-40.
8. Situnayke RD, Crump BJ, Thurnham DI, Davies JA, Gearty J, Davis M. Lipid peroxidation and hepatic antioxidants in alcoholic liver disease. Gut 1990; 31: 1311-7.
9. Shaw S, Rubin KP, Lieber CS. Depressed hepatic glutathione and increased diene conjugates in alcoholic liver disease; evidence of lipid peroxidation. Dig Dis Sci 1983; 28: 585-92.
10. The Law of 21 August 1997 on animal protection. Off J Laws 1997, 111, 3445-53 [in Polish].
11. Kamath SA, Kummerow FA, Narayan KA. A simple procedure for the isolation of rat liver microsomes. FEBS Lett 1971; 17: 90-2.
12. Sawant PL, Shibko S, Kumta US. Tappel AL. Isolation of rat liver lysosomes and their general properties. Bioch Biophys Acta 1964; 85: 82-92.
13. Ellman GI. Tissue sulfhydryls groups. Arch Biochem Biophys 1959; 82: 70-7.
14. Habig WH, Pabst MJ, Jakoby J. Glutathione-S-transferases: The first enzymatic step in mercapturic acid formation. J Biol Chem 1974; 249: 7130-9.
15. Lowry OH, Rosebrough NJ, Farr AI, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265-75.
16. Nimmo-Smith RH. p-Nitrophenyl beta-glucuronide as a substrate for beta-glukuronidase. Biochem Biophys Acta 1961; 50: 166-9.
17. 4 intoxication and vitamin E deficiency. Biochem Med 1980; 23: 302-11.
18. Wills ED. Mechanism of lipid peroxide formation in animal tissues. Biochem J 1966; 99: 667-82.
19. Van Doom R, Bos RP, Brouns RME, Leijdekkors ChM, Henderson PT. Effects of toluene and xylene on liver glutathione and their urinary excretion as mercapturic acids in the rat. Arch Toxicol 1980; 43: 293-303.
20. Gonzalez-Reche LM, Schettgen T, Angerer J. New approaches to the metabolism of xylenes: verification of the formation of phenylmercapturic acid metabolites of xylenes. Arch Toxicol 2003; 77: 80-5.
21. Angerer J, Schildbach M, Kramer A. S-p-Toluylmercapturic acid in the urine of workers exposed to toluene: a new biomarker for toluene exposure. Arch Toxicol 1998; 72: 119-23.
22. Sippel HW. Effect of an acute dose of ethanol on lipid peroxidation and on the activity of microsomal glutathione-S-transferase in rat liver. Acta Pharmacol Toxicol 1983; 53: 135-40.
23. Sampey BP, Korourian S, Ronis MJ, Badger TM, Petersen DR. Immunohistochemical characterization of hepatic malondialdehyde and 4-hydroxynonenal modified proteins during early stages of ethanol-induced liver injury. Alcohol Clin Exp Res 2003; 27(6): 1015-22.
24. Comporti M, Burdino E, Raja F. Fatty acid composition of mitochondrial and microsomal lipids after acute ethanol intoxication. Life Sci 1971; 10: 855-66.
25. Grover PL. Glutathione-S-transferases in detoxification. Biochem Soc Trans 1982; 10: 80-2.
26. Wills ED, Wilkinson AE. Release of enzymes from lysosomes by irradiation and the relation of lipid peroxide formation to enzyme release. Biochem J 1966; 99: 657-66.
27. De Duve C, Wattioux R. Function of lysosomes. Am Rev Physiol 1966; 28: 435-92.
28. Nakajima T, Okuyama S, Yonekura I, Sato A. Effects of ethanol and phenobarbital administration on the metabolism and toxicity of benzene. Chem-Biol Interact 1985; 55: 23-38.
29. Wrońska-Nofer T, Klimczak J, Wiśniewska-Knypl JM, Jajte J, Opalska B. Combined effect of ethanol and carbon disulphide on cytochrome P-450 monooxygenese, lipid peroxidation and ultrastructure of the liver in chronically exposed rats. J Appl Toxicol 1986; 6: 297-305.
30. Yalcin AS, Kocak-Toker N, Unysal M, Aykac G, Sives A, Öz H. Influence of carbon tetrachloride-ethanol treatment on hepatic lipid peroxidation and glutathione-dependent enzymes in rats. IRCS Med Sci 1989; 13: 1143-4.
31. Piotrowska D, Długosz A, Pajak J. Antioxidative properties of coenzyme Q10 and vitamin E in exposure to xylene and gasoline and their mixture with methanol. Acta Pol Pharm 2002; 59(6): 427-32.