Expression of protein gene product 9.5 in lepromatous eyes showing ciliary body nerve damage and a "dying back" phenomenon in the posterior ciliary nerves

British Journal of Ophthalmology

Volumn 88, Issue 2, 2004, Pages 178-181

  Ebenezer, G J ^a   Daniel, E ^a  

^a Schieffelin Leprosy Res/Train Ctr   (India)

Author keywords

[No Author keywords available]

Indexed keywords

DAPSONE; GENE PRODUCT;

ADULT; ANESTHESIA; ARTICLE; CASE REPORT; CILIARY NERVE; COMPARATIVE STUDY; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; LEPROMATOUS LEPROSY; MALE; NERVE INJURY; NEUROPATHY; OPTIC NERVE; PATCH TEST; PRIORITY JOURNAL; SCLERA; STAINING;

ADULT; BIOLOGICAL MARKERS; CILIARY BODY; EYE INFECTIONS, BACTERIAL; HUMANS; LEPROSY, LEPROMATOUS; MALE; MYCOBACTERIUM LEPRAE; NEUROPEPTIDES; PERIPHERAL NERVOUS SYSTEM DISEASES; SCLERA; UBIQUITIN THIOLESTERASE;

EID: 0942279524     PISSN: 00071161     EISSN: None     Source Type: Journal    
DOI: 10.1136/bjo.2003.027276     Document Type: Article

References (19)

1. Lockwood DNJ. Leprosy elimination - a virtual phenomenon or a reality? BMJ 2002;324:1516-18.
2. Daniel E, Ebenezer GJ, Job CK. Pathology of iris in leprosy. Br J Ophthalmol 1997;81:490-2.
3. Job CK, Ebenezer GJ, Thompson K, et al. Pathology of eye in leprosy. Indian J Lepr 1998;70:79-92.
4. Daniel E, Ebenezer GJ. Pathology of a lepromatous eye. Int J Lepr Other Mycobact Dis 2000;68:23-6.
5. Daniel E, Ebenezer GJ, Ffytche TJ, et al. Epithelioid granuloma in the iris of a lepromatous leprosy patient: an unusual finding. Int J Lepr Other Mycobact Dis 2000;68:152-4.
6. McArthur JC, Stocks AE, Hauer P, et al. Epidermal nerve fiber density-normative reference range and diagnostic efficiency. Arch Neurol 1998;55:1513-20.
7. Lowe J, McDermott H, London M, et al. Ubiquitin carboxyl-terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases. J Pathol 1990;161:153-60.
8. Wilkinson KD, Lee K, Deshpande S, et al. The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase. Science 1989;246:670-5.
9. Thompson RJ, Doran JF, Jackson P, et al. PGP 9.5 - a new marker for vertebrate neurons and neuronendocrine cells. Brain Res 1983;278:224-8.
10. Hibi K, Westra WH, Borges M, et al. PGP9.5 as a candidate tumor marker for non-small-cell lung cancer. Am J Pathol 1999;155:711-5.
11. Furuno K, Wakakura M, Shimizu K, et al. Immunohistochemical studies of Merkel cell carcinoma of the eyelid. Jpn J Ophthalmol 1992;36:348-55.
12. Tezel E, Hibi K, Nagasaka T, et al. PGP9.5 as a prognostic factor in pancreatic cancer. Clin Cancer Res 2000;6:4764-7.
13. Gavazzi I, Canavan RE, Cowen T. Influence of age and anti-nerve growth factor treatment on the sympathetic and sensory innervation of the rat iris. Neuroscience 1996;73:1069-79.
14. Marfurt CF, Jones MA, Thrasher K. Parasympathetic innervation of the rat cornea. Exp Eye Res 1998;66:437-48.
15. Rios JD, Forde K, Diebold Y, et al. Development of conjunctival goblet cells and their neuroreceptor subtype expression. Invest Ophthalmol Vis Sci 2000;41:2127-37.
16. Marfurt CF, Murphy CJ, Florczak JL. Morphology and neurochemistry of canine corneal innervation. Invest Ophthalmol Vis Sci 2001;42:2242-51.
17. Nakajima J, Mekada A, Nakamura J, et al. Expression of protein gene product 9.5 in the anterior lens epithelial cells of atopic cataracts. J Cataract Refract Surg 2002;28:2035-9.
18. Bron AJ, Tripathi RC, Tripathi BJ. Wolff's. In: Anatomy of the Eye and the orbit: The Ciliary Body. 8th ed. London UK: Chapman and Hall, 1977:360-1.
19. Weddell G. Disorders of peripheral cutaneous nerves. J Invest Dermatol 1977;69:130-5.