Low calcium intake is associated with decreased adrenal androgens and reduced bone age in premenarcheal girls in the last pubertal stages

Journal of Bone and Mineral Metabolism

Volumn 22, Issue 1, 2004, Pages 64-70

  Bonofiglio, Daniela ^a   Garofalo, Cecilia ^a   Catalano, Stefania ^a   Marsico, Stefania ^a   Aquila, Saveria ^a   Andò, Sebastiano ^a  

^a UNIVERSITY OF CALABRIA   (Italy)

Author keywords

Adrenal and gonadal androgens; Bone age; Bone mineral density; Calcium intake

Indexed keywords

25 HYDROXYVITAMIN D; ANDROGEN; ANDROSTANEDIONE; ESTRADIOL; OSTEOCALCIN; PARATHYROID HORMONE; PRASTERONE; PRASTERONE SULFATE; TESTOSTERONE;

ADOLESCENT; ADRENAL GLAND; AGE; ARTICLE; BONE AGE; BONE MATURATION; CALCIUM HOMEOSTASIS; CALCIUM INTAKE; CHILD; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; HUMAN; HUMAN EXPERIMENT; MENARCHE; NORMAL HUMAN; PRIORITY JOURNAL; PUBERTY; RADIUS;

ADOLESCENT; ADRENAL GLANDS; AGE DETERMINATION BY SKELETON; ANDROGENS; ANDROSTENEDIONE; BODY MASS INDEX; BODY WEIGHTS AND MEASURES; BONE DENSITY; CALCIUM, DIETARY; CHILD; DEHYDROEPIANDROSTERONE; DEHYDROEPIANDROSTERONE SULFATE; DENSITOMETRY, X-RAY; ESTRADIOL; FEMALE; HUMANS; MENARCHE; OSTEOCALCIN; PARATHYROID HORMONE; PUBERTY; RADIUS; REGRESSION ANALYSIS; SEX HORMONE-BINDING GLOBULIN; TESTOSTERONE; VITAMIN D;

EID: 0942276864     PISSN: 09148779     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00774-003-0451-5     Document Type: Article

References (46)

1. Matkovic V, Fontana D, Tominac C, Goel P, Chestnut CH III (1990) Factors that influence peak bone mass formation: a study of calcium balance and the inheritance of bone mass in adolescent females. Am J Clin Nutr 52:878-888
2. Johnston CC, Miller JZ, Slemenda CW, Reister TK, Hui S, Christian JC, Peacock M (1992) Calcium supplementation and increases in bone mineral density in children. N Engl J Med 327:82-87
3. Gilsanz V, Gibbens DT, Roe TF, Carlson M, Senac MO, Boechat MI, Huang HK, Schulz EE, Libanati CR, Cann CC (1988) Vertebral bone density in children: effect of puberty. Radiology 166:847-850
4. Glastre C, Braillon P, David L, Cochat P, Meunier PJ, Delmas PD (1990) Measurement of bone mineral content of the lumbar spine by dual energy X-ray absorptiometry in normal children: correlations with growth parameters. J Clin Endocrinol Metab 70:1330-1333
5. Grumbach MM, Auchus RJ (1999) Estrogen: consequences and implications of human mutations in synthesis and action. J Clin Endocrinol Metab 84:4677-4694
6. Grumbach MM (2000) Estrogen, bone, growth, and sex: a sea change in conventional wisdom. J Pediatr Endocrinol Metab 13 (Suppl 6):1439-1455
7. Canalis E (1994) Skeletal growth factors and aging. J Clin Endocrinol Metab 78:1009-1010
8. Turner RT, Riggs BL, Spelsberg TC (1994) Skeletal effects of estrogen. Endocr Rev 15:275-300
9. Cummings SR, Browner WS, Bauer D, Stone K, Ensrud K, Jamal S, Ettinger B (1998) Endogenous hormones and the risk of hip and vertebral fractures among older women. Study of Osteoporotic Fractures Research Group. N Engl J Med 339:733-738
10. Khosla S, Melton LJ, Atkinson EJ, O'Fallon WM, Klee GG, Riggs BL (1998) Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen. J Clin Endocrinol Metab 83:2266-2274
11. Raisz LG, Prestwood KM (1998) Estrogen and the risk of fracture: new data, new questions. N Engl J Med 339:767-768
12. Hofbauer LC, Khosla S (1999) Androgen effects on bone metabolism: recent progress and controversies. Eur J Endocrinol 140: 271-286
13. Orwoll ES (1996) Androgens as anabolic agents for bone. Trends Endocrinol Metab 7:77-84
14. Kardinaal AF, Andò S, Charles P, Charzewska J, Rotily M, Vaananen K, Van Erp-Baart AM, Heikkinen J, Thomsen J, Maggiolini M, Deloraine A, Chabros E, Juvin R, Schaafsma G (1999) Dietary calcium and bone density in adolescent girls and young women in Europe. J Bone Miner Res 14:583-592
15. Istituto Nazionale della Nutrizione (1997) Tabelle di composizione degli alimenti. Milan, EDRA
16. Vermeulen A, Stoica T, Verdonck L (1971) The apparent free testosterone concentration, an index of androgenicity. J Clin Endocrinol Metab 33:759-767
17. Tanner JM (1978) Physical growth and development, In: Forfar JO, Arnell CC (eds) Textbook of Pediatrics. Churchill Livingstone, Edinburgh, pp 249-303
18. Leboff MS, Fuleihan GE, Angell JE, Chung S, Curtis K (1992) Dual energy X-ray absorptiometry of the forearm: reproducibility and correlation with single-photon absorptiometry. J Bone Miner Res 7:841-846
19. Tanner JM, Whitehouse RH, Cameron N, Marshall WA, Healy MJR, Goldstein H (1983) Assessment of skeletal maturity and prediction of adult height. Academic, London
20. Standing Committee on the Scientific Evaluation of Dietary Reference Intakes (1999) Dietary Reference Intake: Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. National Academy, Washington, DC
21. Remer T, Manz F (1999) Role of nutritional status in the regulation of adrenarche. J Clin Endocrinol Metab 84:3936-3944
22. Attia N, Tamborlane WV, Heptulla R, Maggs D, Grozman A, Sherwin RS, Caprio S (1998) The metabolic syndrome and insulin-like growth factor I regulation in adolescent obesity. J Clin Endocrinol Metab 83:1467-1471
23. Radetti G, Bozzola M, Pasquino B, Paganini C, Aglialoro A, Livieri C, Barreca A (1998) Growth hormone bioactivity, insulin-like growth factors (IGFs), and IGF binding proteins in obese children. Metabolism 47:1490-1493
24. Fottner C, Engelhardt D, Weber MM (1998) Regulation of steroidogenesis by insulin-like growth factors (IGFs) in adult human adrenocortical cells: IGF-I and, more potently, IGF-II preferentially enhance androgen biosynthesis through interaction with the IGF-I receptor and IGF-binding proteins. J Endocrinol 158:409-417
25. Endoh A, Kristiansen SB, Casson PR, Buster JE, Hornsby PJ (1996) The zona reticularis is the site of biosynthesis of dehydroepiandrosterone and dehydroepiandrosterone sulfate in the adult human cortex resulting from its low expression of 3 β-hydroxysteroid dehydrogenase. J Clin Endocrinol Metab 81:3558-3565
26. L'Allemand D, Penhoat A, Lebrethon MC, Ardevol R, Baehr V, Oelkers W, Saez JM (1996) Insulin-like growth factors enhance steroidogenic enzyme and corticotropin receptor messenger ribonucleic acid levels and corticotropin steroidogenic responsiveness in cultured human adrenocortical cells. J Clin Endocrinol Metab 81:3892-3897
27. Murphy S, Khaw K, Cassidy A, Compston JE (1993) Sex hormones and bone mineral density in elderly men. Bone Miner 20:133-140
28. Ongphiphadhanakul B, Rajatanavin R, Chailurkit L, Piaseu N, Teerarungsikul K, Sirisriro R, Komindr S, Puavilai G (1995) Serum testosterone and its relation to bone mineral density and body composition in normal males. Clin Endocrinol 43:727-733
29. Kelly PJ, Pocock NA, Sambrook PN, Eisman JA (1990) Dietary calcium, sex hormones and bone mineral density in men. BMJ 300:1361-1364
30. Orwoll ES (1996) Androgens. In: Bilezekian JP, Raisz LG, Rodan GA (eds) Principles of Bone Biology. Academic, San Diego, CA, pp 563-580
31. Kasperk CH, Wakley GK, Hierl T, Ziegler R (1997) Gonadal and adrenal androgens are potent regulators of human bone cell metabolism in vitro. J Bone Miner Res 12:464-471
32. Colvard DS, Eriksen EF, Keeting PE, Wilson EM, Lubahn DB, French FS, Riggs BL, Spelsberg TC (1989) Identification of androgen receptors in normal human osteoblast-like cells. Proc Natl Acad Sci USA 86:854-857
33. Bellido T, Jilka RL, Boyce BF, Girasole G, Broxmeyer H, Dalrymple SA, Murray R, Manolagas SC (1995) Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor. J Clin Invest 95:2886-2895
34. Abu EO, Horner A, Kusec V, Triffit JT, Compston JE (1997) The localization of androgen receptors in human bone. J Clin Endocrinol Metab 82:3493-3497
35. Mizuno Y, Hosoi T, Inoue S, Ikegami A, Kaneki M, Akedo Y, Nakamura T, Ouchi Y, Chang C, Orimo H (1994) Immunocytochemical identification of androgen receptor in mouse osteoclast-like multinucleated cells. Calcif Tissue Int 54:325-326
36. Nakano Y, Morimoto I, Ishida O, Fujihara T, Mizokami A, Tanimoto A, Yanagihara N, Izumi F, Eto S (1994) The receptor, metabolism and effect of androgen in osteoblastic MC3T3-E1 cells. Bone Miner 26:245-259
37. Shimodaira K, Fujikawa H, Okura F, Shimizu Y, Saito H, Yanaihara T (1996) Osteoblast cells (MG-63 and HOS) have aromatase and 5α-reductase activities. Biochem Mol Biol Int 39:109-116
38. Bruch HR, Wolf L, Budde R, Romalo G, Schweikert HU (1992) Androstenedione metabolism in cultured human osteoblast-like cells. J Clin Endocrinol Metab 75:101-105
39. Nawata H, Tanaka S, Tanaka S, Takayanagi R, Sakau Y, Yanase T, Ikuyama S, Haji M (1995) Aromatase in bone cells: association with osteoporosis in post-menopausal women. J Steroid Biochem Mol Biol 53:165-174
40. Eyre LJ, Bland R, Bujalska IJ, Sheppard MC, Stewart PM, Hewison M (1998) Characterization of aromatase and 17β-hydroxysteroid dehydrogenase expression in rat osteoblastic cells. J Bone Miner Res 13:996-1004
41. Saito H, Yanaihara T (1998) Steroid formation in osteoblast-like cells. J Int Med Res 26:1-12
42. Komm BS, Terpening CM, Benz DJ, Graeme KA, Gallegos A, Korc M, Greene GL, O'Malley BW, Haussler MR (1988) Estrogen binding, receptor mRNA and biologic response in osteoblast-like osteosarcoma cells. Science 241:81-84
43. Eriksen EF, Colvard DS, Berg NJ, Graham ML, Mann KG, Spelsberg TC, Riggs BL (1988) Evidence of estrogen receptors in normal human osteoblast-like cells. Science 241:84-86
44. Jilka RL, Hangoc G, Girasole G, Passeri G, Williams DC, Abrams JS, Boyce B, Broxmeyer H, Manolagas SC (1992) Increased osteoclast development after estrogen loss: mediation by interleukin-6. Science 257:88-91
45. Girasole G, Jilka RL, Passeri G, Boswell S, Boder G, Williams DC, Manolagas SC (1992) 17 Beta-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens. J Clin Invest 89:883-891
46. Selby C (1990) Sex hormone binding globulin: origin, function and clinical significance. Ann Clin Biochem 27:532-541