A Pyrophosphatase Regulating Polyphosphate Metabolism in Acidocalcisomes Is Essential for Trypanosoma brucei Virulence in Mice

Journal of Biological Chemistry

Volumn 279, Issue 5, 2004, Pages 3420-3425

  Lemercier, Guillaume ^a   Espiau, Benoit ^a   Ruiz, Felix A ^b   Vieira, Mauricio ^b   Luo, Shuhong ^b   Baltz, Theo ^a   Docampo, Roberto ^b   Bakalara, Norbert ^a  

^a CNRS   (France)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CALCIUM; METABOLISM; PH EFFECTS; PROTEINS; RNA;

BLOODSTREAM FORM (BF);

BIOCHEMISTRY;

ADENOSINE TRIPHOSPHATASE; CALCIUM; DOUBLE STRANDED RNA; EXOPOLYPHOSPHATASE; HYDROLASE; INORGANIC PYROPHOSPHATASE; MAGNESIUM; PHOSPHATE; POLYPHOSPHATE; PROTEINASE; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; VSP1 PROTEIN, TRYPANOSOMA BRUCEI; ZINC;

AMINO ACID SEQUENCE; ANALYTIC METHOD; ANIMAL; ANIMAL CELL; ARTICLE; BACTERIAL VIRULENCE; CELL COMPARTMENTALIZATION; CHEMISTRY; CHROMATOGRAPHY; COSMID; DOSE RESPONSE; ELECTRON MICROSCOPY; ENZYME ANALYSIS; ENZYME SPECIFICITY; GEL CHROMATOGRAPHY; GENETIC TRANSFECTION; HYDROLYSIS; IMMUNOBLOTTING; KINETICS; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OLIGOMERIZATION; OSMOSIS; OSMOTIC STRESS; PATHOGENICITY; PH; PHENOTYPE; PHOSPHATE METABOLISM; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN TERTIARY STRUCTURE; RNA INTERFERENCE; SEQUENCE HOMOLOGY; STARVATION; TIME; TRYPANOSOMA BRUCEI; VIRULENCE; WESTERN BLOTTING;

ACID ANHYDRIDE HYDROLASES; ADENOSINE TRIPHOSPHATASES; AMINO ACID SEQUENCE; ANIMALS; BLOTTING, WESTERN; CALCIUM; CHROMATOGRAPHY; CHROMATOGRAPHY, GEL; CLONING, MOLECULAR; COSMIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPEPTIDASES; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; IMMUNOBLOTTING; KINETICS; MAGNESIUM; MICE; MICROSCOPY, ELECTRON; MOLECULAR SEQUENCE DATA; OSMOSIS; PHENOTYPE; PHOSPHATES; POLYPHOSPHATES; PROTEIN STRUCTURE, TERTIARY; PROTOZOAN PROTEINS; PYROPHOSPHATASES; RECOMBINANT PROTEINS; RNA INTERFERENCE; RNA, DOUBLE-STRANDED; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; TIME FACTORS; TRANSFECTION; TRYPANOSOMA BRUCEI BRUCEI; VIRULENCE; ZINC;

ANIMALIA; BACTERIA (MICROORGANISMS); MAMMALIA; PROTOZOA; TRYPANOSOMA; TRYPANOSOMA BRUCEI;

EID: 0942276378     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M309974200     Document Type: Article

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