Molecular basis of the high-affinity activation of type 1 ryanodine receptors by imperatoxin A

Biochemical Journal

Volumn 377, Issue 2, 2004, Pages 385-394

  Lee, Chul Won ^a   Lee, Eun Hui ^a   Takeuchi, Koh ^b   Takahashi, Hideo ^b   Shimada, Ichio ^b   Sato, Kazuki ^c   Shin, Song Yub ^d   Kim, Do Han ^a   Kim, Jae Il ^a  

^a Gwangju Institute of Science and Technology (GIST)   (South Korea)

^b UNIVERSITY OF TOKYO   (Japan)

^c FUKUOKA WOMEN'S UNIVERSITY   (Japan)

^d Chosun University   (South Korea)

Author keywords

Excitation contraction coupling; Imperatoxin A; NMR; Peptide A; Ryanodine receptor; Solution structure

Indexed keywords

CHEMICAL ACTIVATION; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEINS; SOLUTIONS;

HIGH-AFFINITY ACTIVATION;

BIOCHEMISTRY;

ALANINE; CYSTEINE; IMPERATOXIN A; INSECT VENOM; PEPTIDE; RYANODINE RECEPTOR; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; BETA SHEET; CARBOXY TERMINAL SEQUENCE; EXCITATION CONTRACTION COUPLING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN FUNCTION; RECEPTOR AFFINITY; RECEPTOR INTRINSIC ACTIVITY;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OMEGA-CONOTOXINS; PEPTIDE FRAGMENTS; RABBITS; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SCORPION VENOMS; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP;

INSECTA; SCORPIONES;

EID: 0942268726     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20031192     Document Type: Article

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