Microstimulation in the Region of the Human Thalamic Principal Somatic Sensory Nucleus Evokes Sensations Like Those of Mechanical Stimulation and Movement

Journal of Neurophysiology

Volumn 91, Issue 2, 2004, Pages 736-745

  Ohara, Shinji ^a   Weiss, Nirit ^a   Lenz, Fred A ^a  

^a JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BODY MOVEMENT; BRAIN DEPTH STIMULATION; BRAIN REGION; EVOKED RESPONSE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MECHANICAL STIMULATION; MECHANORECEPTOR; MONKEY; MOVEMENT (PHYSIOLOGY); PRESSURE; PRIORITY JOURNAL; SOMATOSENSORY CORTEX; THALAMUS NUCLEUS; THALAMUS POSTERIOR NUCLEUS; THALAMUS VENTRAL NUCLEUS; TOUCH; TREMOR; VIBRATION;

ANALYSIS OF VARIANCE; CHI-SQUARE DISTRIBUTION; ELECTRIC STIMULATION; FEMALE; HUMANS; MALE; MOVEMENT; PHYSICAL STIMULATION; SENSORY THRESHOLDS; THALAMIC NUCLEI; TOUCH; VIBRATION;

EID: 0842349520     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.00648.2003     Document Type: Article

References (55)

1. Brodal A. Neurological Anatomy. Oxford, UK: Oxford Univ. Press, 1981.
2. Brodmann K. Vergleichende Lokalisationslehre der Grosshirnrinde. Leipzig, Germany: J. A. Barth, 1907.
3. Byl NN, Merzenich MM, and Jenkins WM. A primate genesis model of focal dystonia and repetitive strain injury. I. Learning-induced dedifferentiation of the representation of the hand in the primary somatosensory cortex in adult monkeys. Neurology 47: 508-520, 1996.
4. Davis KD, Kiss ZH, Tasker RR, and Dostrovsky JO. Thalamic stimulation-evoked sensations in chronic pain patients and in nonpain (movement disorder) patients. J Neurophysiol 75: 1026-1037, 1996.
5. Davis KD, Lozano RM, Manduch M, Tasker RR, Kiss ZH, and Dostrovsky JO. Thalamic relay site for cold perception in humans. J Neurophysiol 81: 1970-1973, 1999.
6. Dostrovsky JO, Wells FEB, and Tasker RR. Pain evoked by stimulation in human thalamus. In: International Symposium on Processing Nociceptive Information, edited by Sjigenaga Y. Amsterdam: Elsevier. 1991, p. 115-120.
7. Dykes RW, Sur M, Merzenich MM, Kaas JH, and Nelson RJ. Regional segregation of neurons responding to quickly adapting, slowly adapting, deep and Pacinian receptors within thalamic ventroposterior lateral and ventroposterior inferior nuclei in the squirrel monkey (Saimiri sciureus). Neuroscience 6: 1687-1692, 1981.
8. Friedman DP and Jones EG. Thalamic input to areas 3a and 2 in monkeys. J Neurophysiol 45: 59-85, 1981.
9. Gillingham FJ. Bilateral stereotactic lesions in the management of parkinsonism. J Neurosurg 24: 449-453, 1966.
10. Hirai T and Jones EG. A new parcellation of the human thalamus on the basis of histochemical staining. Brain Res Rev 14: 1-34, 1989.
11. Johansson RS, Trulsson M, Olsson KA, and Westberg KG. Mechanoreceptor activity from the human face and oral mucosa. Exp Brain Res 72: 204-208, 1988.
12. Johnson KO, Yoshioka T, and Vega-Bermudez F. Tactile functions of mechanoreceptive afferents innervating the hand. J Clin Neurophysiol 17: 539-558, 2000.
13. Jones EG. The Thalamus. New York: Plenum, 1985.
14. Jones EG and Friedman DP. Projection pattern of functional components of thalamic ventrobasal complex on monkey somatosensory cortex. J Neurophysiol 48: 521-544, 1982.
15. Jones EG, Friedman DP, and Hendry SH. Thalamic basis of place- and modality-specific columns in monkey somatosensory cortex: a correlative anatomical and physiological study. J Neurophysiol 48: 545-568, 1982.
16. Kaas JH, Nelson RJ, Sur M, Dykes RW, and Merzenich MM. The somatotopic organization of the ventroposterior thalamus of the squirrel monkey. Saimiri sciureus. J Comp Neurol 226: 111-140, 1984.
17. Lenz FA and Byl NN. Reorganization in the cutaneous core of the human thalamic principal somatic sensory nucleus (ventral caudal) in patients with dystonia. J Neurophysiol 82: 3204-3212, 1999.
18. Lenz FA, Dostrovsky JO, Tasker RR, Yamashiro K, Kwan HC, and Murphy JT. Single-unit analysis of the human ventral thalamic nuclear group: somatosensory responses. J Neurophysiol 59: 299-316, 1988.
19. Lenz FA, Gracely RH, Baker FH, Richardson RT, and Dougherty PM. Reorganization of sensory modalities evoked by microstimulation in region of the thalamic principal sensory nucleus in patients with pain due to nervous system injury. J Comp Neurol 399: 125-138, 1998.
20. Lenz FA, Gracely RH, Hope EJ, Baker FH, Rowland LH, Dougherty PM, and Richardson RT. The sensation of angina can be evoked by stimulation of the human thalamus. Pain 59: 119-125, 1994a.
21. Lenz FA, Gracely RH, Rowland LH, Dougherty PM, and Lee JI. Sensations evoked by stimulation with bursts of different numbers of stimuli and frequencies in the region of the human thalamic principal somatosensory nucleus. Soc Neurosci Abstr 26: 2105, 2000.
22. Lenz FA, Kwan HC, Dostrovsky JO, and Tasker RR. Characteristics of the bursting pattern of action potentials that occurs in the thalamus of patients with central pain. Brain Res 496: 357-360, 1989.
23. Lenz FA, Kwan HC, Dostrovsky JO, Tasker RR, Murphy JT, and Lenz YE. Single unit analysis of the human ventral thalamic nuclear group. Activity correlated with movement. Brain 113: 1795-1821, 1990.
24. Lenz FA, Kwan HC, Martin R, Tasker R, Richardson RT, and Dostrovsky JO. Characteristics of somatotopic organization and spontaneous neuronal activity in the region of the thalamic principal sensory nucleus in patients with spinal cord transection. J Neurophysiol 72: 1570-1587, 1994b.
25. Lenz FA, Kwan HC, Martin RL, Tasker RR, Dostrovsky JO, and Lenz YE. Single unit analysis of the human ventral thalamic nuclear group. Tremor-related activity in functionally identified cells. Brain 117: 531-543, 1994c.
26. Lenz FA, Normand SL, Kwan HC, Andrews D, Rowland LH, Jones MW, Seike M, Lin YC, Tasker RR, and Dostrovsky JO. Statistical prediction of the optimal site for thalamotomy in parkinsonian tremor. Mov Disord 10: 318-328, 1995.
27. Lenz FA, Seike M, Richardson RT, Lin YC, Baker FH, Khoja I, Jaeger CJ, and Gracely RH. Thermal and pain sensations evoked by microstimulation in the area of human ventrocaudal nucleus. J Neurophysiol 70: 200-212, 1993.
28. Libet B, Alberts WW, Wright EW Jr, and Feinstein B. Responses of human somatosensory cortex to stimuli below threshold for conscious sensation. Science 158: 1597-1600, 1967.
29. Libet B, Pearl DK, Morledge DE, Gleason CA, Hosobuchi Y, and Barbaro NM. Control of the transition from sensory detection to sensory awareness in man by the duration of a thalamic stimulus. The cerebral "time-on" factor. Brain 114: 1731-1757, 1991.
30. Mandir AS, Rowland LH, Dougherty PM, and Lenz FA. Microelectrode recording and stimulation techniques during stereotactic procedures in the thalamus and pallidum. Adv Neurol 74: 159-165, 1997.
31. McCloskey DI, Cross MJ, Honner R, and Potter EK. Sensory effects of pulling or vibrating exposed tendons in man. Brain 106: 21-37, 1983.
32. Mountcastle VB. Central nervous mechanisms in mechanoreceptive sensibility. In: Handbook of Physiology. The Nervous System. Sensory Processes, edited by Brookhart JM, Mountcastle VB, Smith ID, and Geiger SR. Bethesda, MD: Am. Physiol. Soc., 1984, sect, 1, vol. III, p. 789-878.
33. Nordin M and Hagbarth KE. Mechanoreceptive units in the human infraorbital nerve. Acta Physiol Scand 135: 149-161, 1989.
34. Ochoa J and Torebjork E. Sensations evoked by intraneural microstimulation of single mechanoreceptor units innervating the human hand. J Physiol 342: 633-654, 1983.
35. Ohara S and Lenz FA. Medial lateral extent of thermal and pain sensations evoked by microstimulation in somatic sensory nuclei of human thalamus. J Neurophysiol 2003.
36. Ohye C, Shibazaki T, Hirai T, Wada H, Hirato M, and Kawashima Y. Further physiological observations on the ventralis intermedius neurons in the human thalamus. J Neurophysiol 61: 488-500, 1989.
37. Penfield W and Jasper H. Epilepsy and the Functional Anatomy of the Human Brain. Boston, MA: Little Brown, 1954.
38. Poggio GF and Mountcastle VB. The functional properties of ventrobasal thalamic neurons studied in unanesthetized monkeys. J Neurophysiol 26: 775-806, 1963.
39. Ranck JB Jr. Which elements are excited in electrical stimulation of mammalian central nervous system: a review. Brain Res 98: 417-440, 1975.
40. Romo R, Hernandez A, Zainos A, Brody CD, and Lemus L. Sensing without touching: psychophysical performance based on cortical microstimulation. Neuron 26: 273-278, 2000.
41. Romo R, Hernandez A, Zainos A, and Salinas E. Somatosensory discrimination based on cortical microstimulation. Nature 392: 387-390, 1998.
42. Snedecor GW and Cochran WG. Statistical Methods. Ames. IA: Iowa State University Press, 1967.
43. Somjen GG. Neurophysiology Studied in Man. Amsterdam: Excerpta Medica, 1972.
44. Sur M, Wall JT, and Kaas JH. Modular segregation of functional cell classes within the postcentral somatosensory cortex of monkeys. Science 212: 1059-1061, 1981.
45. Tasker RR and Organ LW. Mapping the somatosensory and auditory pathways in the upper midbrain and thalamus of man. In: Neurophysiology Studied in Man, edited by Somjen GG. Amsterdam: Excerpta Med, 1972, p. 169-187.
46. Tasker RR, Organ LW, and Hawrylyshyn PA. Sensory organization of the human thalamus. Appl Neurophysiol 39: 139-153, 1976.
47. Torebjork HE, Schady W, and Ochoa J. Sensory correlates of somatic afferent fibre activation. Hum Neurobiol 3: 15-20, 1984.
48. Vallbo AB. Sensations evoked from the glabrous skin of the human hand by electrical stimulation of unitary mechanosensitive afferents. Brain Res 215: 359-363, 1981.
49. Vallbo AB, Olsson KA, Westberg KG, and Clark FJ. Microstimulation of single tactile afferents from the human hand. Sensory attributes related to unit type and properties of receptive fields. Brain 107: 727-749, 1984.
50. Wall PD and McMahon SB. Microneuronography and its relation to perceived sensation. A critical review. Pain 21: 209-229, 1985.
51. Warren S, Kelahan AM, and Pubols BH Jr. The somatosensory thalamus of the raccoon: properties of single neurons responsive to light mechanical stimulation of the forepaw. J Neurosci 6: 308-317, 1986.
52. Willis WD and Coggeshall RE. Sensory Mechanisms of the Spinal Cord. New York: Plenum, 1991.
53. Woolsey CN, Erickson TC, and Gilson WE. Localization in somatic sensory and motor areas of human cerebral cortex as determined by direct recording of evoked potentials and electrical stimulation. J Neurosurg 51: 476-506, 1979.
54. Zhang HQ, Murray GM, Coleman GT, Turman AB, Zhang SP, and Rowe MJ. Functional characteristics of the parallel SI- and SII-projecting neurons of the thalamic ventral posterior nucleus in the marmoset. J Neurophysiol 85: 1805-1822, 2001.
55. Zirh TA, Lenz FA, Reich SG, and Dougherty PM. Patterns of bursting occurring in thalamic cells during parkinsonian tremor. Neuroscience 83: 107-121, 1998.