Phase 2 clinical study of 123I-N-(2-diethylaminoethyl)-2-iodobenzamide in the diagnostic of primary and metastatic ocular melanoma;Étude clinique en phase 2 de la BZA2 (123IN-(2-dié thylaminoéthyl)-2-iodobenzamide) dans le diagnostic du mélanome malin oculaire et de ses métastases

Journal Francais d'Ophtalmologie

Volumn 27, Issue 1, 2004, Pages 34-39

  Sillaire Houtmann, I ^a   Bonafous, J ^b,c   Veyre, A ^b,c   Mestas, D ^c   D'Incan, M ^d   Moins, N ^b   Kemeny, J L ^a   Chossat, F ^e   Bacin, F ^a  

^a SERVICE DE RHUMATOLOGIE   (France)

^b INSERM   (France)

^c CENTRE JEAN PERRIN   (France)

^d HÔTEL DIEU   (France)

^e CIS Bio International   (France)

Author keywords

BZA2; Metastases; Ocular melanoma; Scintigraphy

Indexed keywords

BENZAMIDE DERIVATIVE; CONTRAST MEDIUM; IODINE 123; N (2 DIETHYLAMINOETHYL) 2 IODOBENZAMIDE I 123; UNCLASSIFIED DRUG; DIAGNOSTIC AGENT; N (2 (DIETHYLAMINO)ETHYL) 4 IODOBENZAMIDE; N-(2-(DIETHYLAMINO)ETHYL)-4-IODOBENZAMIDE; RADIOACTIVE IODINE; RADIOPHARMACEUTICAL AGENT;

ANGIOGRAPHY; APUDOMA; ARTICLE; BONE METASTASIS; CLINICAL ARTICLE; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; CONTRAST ENHANCEMENT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ECHOOCULOGRAPHY; ENDOCRINE TUMOR; EYE CANCER; FEMALE; HUMAN; IMAGE QUALITY; INTERMETHOD COMPARISON; MALE; MELANOMA; METASTASIS; OPHTHALMOSCOPY; PHASE 2 CLINICAL TRIAL; PIGMENTATION; SCINTISCANNING; SENSITIVITY AND SPECIFICITY; SIDE EFFECT; CHOROID TUMOR; CILIARY BODY; CONJUNCTIVA TUMOR; DIFFERENTIAL DIAGNOSIS; ECHOGRAPHY; EYE TUMOR; LIVER TUMOR; PREDICTION AND FORECASTING; SKIN TUMOR; UVEA TUMOR;

BENZAMIDES; CHOROID NEOPLASMS; CILIARY BODY; CONJUNCTIVAL NEOPLASMS; DIAGNOSIS, DIFFERENTIAL; EYE NEOPLASMS; FEMALE; HUMANS; IODINE RADIOISOTOPES; LIVER NEOPLASMS; MALE; MELANOMA; OPHTHALMOSCOPY; PREDICTIVE VALUE OF TESTS; RADIOPHARMACEUTICALS; SENSITIVITY AND SPECIFICITY; SKIN NEOPLASMS; TOMOGRAPHY, X-RAY COMPUTED; UVEAL NEOPLASMS;

EID: 0842348965     PISSN: 01815512     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0181-5512(04)96089-5     Document Type: Article

References (10)

1. Leyvraz S, Spataro V, Bauer J et al. Treatment of ocular melanoma metastatic to the liver by hepatic arterial chemotherapy. J Clin Oncol, 1997;15:2589-95.
2. Bacin F, Michelot J, Bonafous J et al. Clinical study of [1231]N-(2-diethylaminoethyl)-4-iodobenzamide in the diagnosis of primary and metastatic ocular melanoma. Acta Ophtalmol Scand, 1998; 76:56-61.
3. Michelot JM, Moreau MF, Veyre AJ et al. Phase II scintigraphic clinical trial of malignant melanoma and metastases with Iodine-123-N-(2-diethylaminoethyl 4-iodobenzamide). J Nucl Med, 1993;34: 1260-6.
4. Labarre P, Papon J, Moreau MF et al. Evaluation in mice of some iodinated melanoma imaging agents using cryosectioning and multi-wire proportional counting. Eur J Nucl Med, 1999;26:494-8.
5. Moreau MF, Michelot J, Papon J et al. Synthesis, radiolabeling and preliminary evaluation in mice of some (N-diethylaminoethyl)-4-iodobenzamide derivated as melanoma imaging agents. Nucl Med Biol, 1995;22:737-47.
6. Chehade F, De Labriolle-Vaylet C, Michelot J et al. Distribution of I-BZA(N-2-diethylaminoethyl-4-iodobenzamide) in grafted melanoma and normal skin: a study by secondary ion mass spectroscopy. Cell Mol Biol, 2001;47:529-34.
7. Larisch R, Schulte KW, Vosberg H et al. Differential accumulation of iodine-123-iodobenzamide in melanotic and amelanotic melanoma metastases in vivo. J Nucl Med, 1998;39:996-1001.
8. Salopek TG, Scott JR, Joshua AV et al. Radioiodinated N-[3-(4-morpholino)propyl]-N-methyl-2-hydroxy-5-iodo-3-methylbenzylamine (ERC9): a new potential melanoma imaging agent. Eur J Nucl Med, 2001;28:408-17.
9. Rinne D, Baum RP, Hor G et al. Primary staging and follow-up of high risk melanoma patients with whole-body 18F-fluorodeoxyglucose positron emission tomography: results of prospective study of 100 patients. Cancer, 1998;82:1664-71.
10. Dietlein M, Krug B, Groth W et al. Positron emission tomography using 18F-fluorodeoxyglucose in advanced stages of malignant melanoma: a comparison of ultrasonographic and radiological methods of diagnosis. Nucl Med Commun, 1999; 20:255-61.