Airway structure, function and development in health and disease

Paediatric Anaesthesia

Volumn 14, Issue 1, 2004, Pages 3-14

  Shaffer, Thomas H ^a,b   Wolfson, Marla R ^a   Panitch, Howard B ^c  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NEMOURS ALFRED I DUPONT HOSPITAL FOR CHILDREN   (United States)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Airway physiology; Bronchopulmonary dysplasia; Immature airway; Measurement; Mechanical ventilation; Pulmonary function

Indexed keywords

ATROPINE; BRONCHODILATING AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; CHOLINERGIC RECEPTOR STIMULATING AGENT; ISOETARINE; ORCIPRENALINE; SALBUTAMOL;

AIRWAY; AIRWAY PRESSURE; AIRWAY RESISTANCE; ARTIFICIAL VENTILATION; BRONCHOSCOPY; CARTILAGE; CHILD; CLINICAL EXAMINATION; CLINICAL TRIAL; CONFERENCE PAPER; DEVELOPMENT; DRUG RESPONSE; ENDOSCOPY; FORCED EXPIRATORY FLOW; HUMAN; IATROGENIC DISEASE; IMAGING; LUNG COMPLIANCE; LUNG RESISTANCE; MEASUREMENT; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RADIODIAGNOSIS; RESPIRATORY EPITHELIUM; RESPIRATORY FUNCTION; RESPIRATORY SYSTEM; RESPIRATORY TRACT INJURY; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE RELAXATION; TRACHEA MUSCLE; TRACHEOBRONCHIAL TREE;

ANIMALS; CARTILAGE; HUMANS; MUSCLE, SMOOTH; RESPIRATION, ARTIFICIAL; RESPIRATORY FUNCTION TESTS; RESPIRATORY MUCOSA; RESPIRATORY PHYSIOLOGY; RESPIRATORY SYSTEM; RESPIRATORY TRACT DISEASES;

EID: 0842330320     PISSN: 11555645     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9592.2003.01207.x     Document Type: Conference Paper

References (94)

1. Northway WA Jr, Rosan RC, Porter DY. Pulmonary disease following respiratory therapy of hyaline membrane disease. Bronchopulmonary dysplasia. N Engl J Med 1967; 276: 357-368.
2. O'Brodovich HM, Mellins RB. Bronchopulmonary dysplasia (state of the art). Ann Rev Respir Dis 1985; 132: 684-709.
3. Watts JL, Ariagno RL, Brady JP. Chronic pulmonary disease in neonates after artificial ventilation: distribution of ventilation and pulmonary interstitial emphysema. Pediatrics 1977; 60: 273-281.
4. Stocks J, Godfrey S. The role of artificial ventilation, oxygen, and CPAP in the pathogenesis of lung damage in neonates: assessment by serial measurements of lung function. Pediatrics 1976; 57: 352-362.
5. Stocks J, Godfrey S, Reynolds EOR. Airway resistance in infants after various treatments for hyaline membrane disease: special emphasis on prolonged high levels of inspired oxygen. Pediatrics 1978; 61: 178-183.
6. Burnard ED, Grattan-Smith P, Picton-Warlow CG et al. Pulmonary insufficiency in prematurity. Aust Pædiatric J 1965; 1: 12-38.
7. Croteau JR, Cook CD. Volume-pressure and length-tension measurements in human tracheal and bronchial segments. J Appl Physiol 1961; 16: 170-172.
8. Bhutani VK, Rubenstein SD, Shaffer TH. Pressure-volume relationships of tracheas in fetal newborn and adult rabbits. Respir Physiol 1981; 43: 221-231.
9. Shaffer TH, Bhutani VK, Wolfson MR et al. In vivo mechanical properties of the developing airway. Pediatr Res 1989; 25: 143-146.
10. Bhutani VK, Koslo RJ, Shaffer TH. The effect of tracheal smooth muscle tone on neonatal airway collapsibility. Pediatr Res 1986; 20: 492-495.
11. Koslo RJ, Bhutani VK, Shaffer TH. The role of tracheal smooth muscle contraction on neonatal tracheal mechanics. Pediatr Res 1986; 2: 1216-1220.
12. Penn RB, Wolfson MR, Shaffer TH. Effect of tracheal smooth muscle tone on collapsibility of immature airways. J Appl Physiol 1988; 65: 863-869.
13. Coburn RF, Thorton D, Arts R. Effect of trachealis muscle contraction on tracheal resistance to airflow. J Appl Physiol 1972; 16: 170-172.
14. Knudson RJ, Knudson DE. Effect of muscle constriction on flow-limiting collapse of isolated canine trachea. J Appl Physiol 1975; 38: 125-131.
15. Fisher JT. Airway smooth muscle contraction at birth: in vivo versus in vitro comparisons to the adult. Can J Physiol Pharmacol 1992; 70: 590-596.
16. Panitch HB, Deoras KS, Wolfson MR et al. Maturational changes in airway smooth muscle structure-function relationships. Pediatr Res 1992; 31: 151-156.
17. Rodriguez RJ, Dreshaj IA, Kumar G et al. Maturation of the cholinergic response of tracheal smooth muscle in the piglet. Pediatr Pulmonol 1994; 18: 28-33.
18. Haxhiu-Poskurica B, Ernsberger P, Haxhiu MA et al. Development of cholinergic innervation and muscarinic receptor subtypes in piglet trachea. Am J Physiol 1993; 264: L606.
19. Sparrow MP, Mitchell HW. Contraction of smooth muscle of pig airway tissues from before birth to maturity. J Appl Physiol 1990; 68: 468-477.
20. Murphy TM, Mitchell RW, Blake JS et al. Expression of airway contractile properties and acetylcholinesterase activity in swine. J Appl Physiol 1989; 67: 174-180.
21. Panitch HB, Allen JL, Ryan JP et al. A comparison of preterm and adult airway smooth muscle mechanics. J Appl Physiol 1989; 66: 1760-1765.
22. Booth RJ, Sparrow MP, Mitchell HW. Early maturation of force production in pig tracheal smooth muscle during fetal development. Am J Respir Cell Mol Biol 1992; 7: 590-597.
23. Kawamoto S, Adelstein RS. Characterization of myosin heavy chains in cultured aorta smooth muscle. J Biol Chem 1987; 262: 7282-7288.
24. Masaki T, Takano-Ohmuro H, Suzuki R et al. Changes in the smooth muscle myosin isoforms during development of chicken gizzard. Mol Biol Muscle Dev 1986; 29: 323-336.
25. Cliff WJ. The aortic tunica media in growing rats studied with the electron microscope. Lab Invest 1967; 17: 599-615.
26. Wolinsky H. Long term effects of hypertension on the rat aorta wall and their relation to concurrent aging changes. Circ Res 1972; 30: 301-309.
27. Driska SP, Laudadio RE, Wolfson MR et al. A method for isolating adult and neonatal airway smooth muscle cells and measuring shortening velocity. J Appl Physiol 1999; 86: 427-435.
28. Cuss FM, Barnes PJ. Epithelial mediators. Am Rev Resp Dis 1987; 136: S32-S35.
29. Aizawa H, Miyazaki N, Shigematsu N et al. A possible role of airway epithelium in modulating hyper-responsiveness. Br J Pharmacol 1988; 93: 139-145.
30. Barnes PJ, Cuss FM, Palmer JB. The effect of airway epithelium on smooth muscle contractility in bovine trachea. Br J Pharmacol 1985; 86: 685-691.
31. Flavahan NA, Aarhus LL, Rimele TJ et al. Respiratory epithelium inhibits bronchial smooth muscle tone. J Appl Physiol 1985; 58: 834-838.
32. Stuart-Smith K, VanHoutte PM. Airway epithelium modulates the responsiveness of porcine bronchial smooth muscle. J Appl Physiol 1988; 65: 721-727.
33. Laitinen LA, Heino M, Laitinen A et al. Damage of the airway epithelium and bronchial reactivity in patients with asthma. Am Rev Respir Dis 1985; 131: 599-606.
34. Panitch HB, Wolfson MR, Shaffer TH. Epithelial modulation of preterm airway smooth muscle contraction. J Appl Physiol 1993; 74: 1437-1443.
35. Gunst SJ, Lai-Fook SJ. Effect of inflation on trachealis muscle tone in canine tracheal segments in vitro. J Appl Physiol 1983; 54: 906-913.
36. Olsen CR, Stevens AE, McIlroy MB. Rigidity of tracheas and bronchi during muscular constriction. J Appl Physiol 1967; 23: 27-34.
37. Gauthier SP, Wolfson MR, Deoras KS et al. Structure-function of airway generations 0 to 4 in the preterm lamb. Pediatr Res 1992; 31: 157-162.
38. Moreno RH, McCormack GS, Mullen JBM et al. Effect of intravenous papain on tracheal pressure-volume curves in rabbits. J Appl Physiol 1986; 60: 247-252.
39. McCormack GS, Moreno RH, Hogg JC et al. Lung mechanics in papain-treated rabbits. J Appl Physiol 1986; 60: 242-246.
40. Penn RB, Wolfson MR, Shaffer TH. Developmental differences in tracheal cartilage mechanics. Pediatr Res 1989; 26: 429-433.
41. Deoras KS, Wolfson MR, Bhutani VK et al. Structural changes in the tracheas of preterm lambs induced by ventilation. Pediatr Res 1989; 26: 434-437.
42. Bhutani VK, Rubenstein D, Shaffer TH. Pressure-induced deformation in immature airways. Pediatr Res 1981; 15: 829-832.
43. Bhutani VK, Ritchie WG, Shaffer TH. Acquired tracheomegaly in very preterm neonates. Am J Dis Child 1986; 140: 449-452.
44. Bhutani VK, Shaffer TH. Time-dependent tracheal deformation in fetal, neonatal, and adult rabbits. Pediatr Res 1982; 16: 830-833.
45. Penn RB, Wolfson MR, Shaffer TH. Effect of ventilation on mechanical properties and pressure-flow relationships of immature airways. Pediatr Res 1988; 23: 519-524.
46. Wolfson MR, Bhutani VK, Shaffer TH et al. Mechanics and energetics of breathing helium in infants with bronchopulmonary dysplasia. J Pediatr 1984; 104: 752-757.
47. Mirmanesh SJ, Abbasi S, Bhutani VK. Alpha-adrenergic bronchoprovocation in neonates with bronchopulmonary dysplasia. J Pediatr 1992; 121: 622-625.
48. Reynolds EOR, Roberton NRC, Wigglesworth JS. Hyaline membrane disease, respiratory distress, and surfactant deficiency. Pediatrics 1968; 42: 758-768.
49. Ackerman NB Jr, Coalson JJ, Kuehl TJ et al. Pulmonary interstitial emphysema in the premature baboon with hyaline membrane disease. Crit Care Med 1984; 12: 512-516.
50. Bhutani VK, Shaffer TH, Abbasi S et al. Effect of high-frequency jet ventilation on preterm and rabbit tracheal mechanics. Pediatr Pulmonol 1986; 2: 327-331.
51. Buckley CJ. The role of bronchial musculature. Lancet 1989; 2: 836-837.
52. Bryan MH, Hardie MJ, Reilly BJ et al. Pulmonary function studies during the first year of life in infants recovering from the respiratory distress syndrome. Pediatrics 1973; 52: 169-178.
53. Gerhardt T, Hehre D, Feller R et al. Serial determination of pulmonary function in infants with chronic lung disease. J Pediatr 1987; 110: 448-456.
54. Morray JP, Fox WW, Kettrick RG et al. Improvement in lung mechanics as a function of age in the infant with severe bronchopulmonary dysplasia. Pediatr Res 1982; 16: 290-294.
55. Tepper RS, Pagtakhan RD, Taussig LM. Noninvasive determination of total respiratory system compliance in infants by the weighted-spirometer method. Am Rev Resp Dis 1984; 130: 461-466.
56. Dreizzen E, Migdal M, Praud JP et al. Passive compliance of total respiratory system in preterm newborn infants with respiratory distress syndrome. J Pediatr 1988; 112: 778-781.
57. Bhutani VK, Abbasi S. Relative likelihood of bronchopulmonary dysplasia based on pulmonary mechanics measured in preterm neonates during the first week of life. J Pediatr 1992; 120: 605-613.
58. Kao LC, Durand DJ, Phillips BL et al. Oral theophylline and diuretics improve pulmonary mechanics in infants with bronchopulmonary dysplasia. J Pediatr 1987; 111: 439-444.
59. Kao LC, Durand DJ, Nickerson BG. Effects of inhaled metaproterenol and atropine on the pulmonary mechanics of infants with bronchopulmonary dysplasia. Pediatr Pulmonol 1989; 6: 74-80.
60. Wilkie RA, Bryan MH. Effect of bronchodilators on airway resistance in ventilator-dependent neonates with chronic lung disease. J Pediatr 1987; 111: 278-282.
61. Arad I, Bar-Yishay E, Eyal F et al. Lung function in infancy and childhood following neonatal intensive care. Pediatr Pulmonol 1987; 3: 29-33.
62. Tepper RS, Morgan WJ, Cota K et al. Expiratory flow limitation in infants with bronchopulmonary dysplasia. J Pediatr 1986; 109: 1040-1046.
63. Panitch HB, Allen JL, Alpert BE et al. Effects of CPAP on lung mechanics in infants with acquired tracheobronchomalacia. Am J Resp Crit Care Med 1994; 150: 1341-1346.
64. Motoyama EK, Fort MD, Klesh KW et al. Early onset of airway reactivity in premature infants with bronchopulmonary dysplasia. Am Rev Respir Dis 1987; 136: 50-57.
65. Mallory GB Jr, Chaney H, Mutich RL et al. Longitudinal changes in lung function during the first 3 years of premature infants with moderate to severe bronchopulmonary dysplasia. Pediatr Pulmonol 1991; 11: 8-14.
66. Panitch HB, Keklikian EN, Motley RA et al. Effect of altering smooth muscle tone on maximal expiratory flows in patients with tracheomalacia. Pediatr Pulmonol 1990; 9: 170-176.
67. Denjean A, Guimaraes H, Migdal M et al. Dose-related bronchodilator response to aerosolized salbutamol (albuterol) in ventilator-dependent premature infants. J Pediatr 1992; 120: 974-979.
68. Cabal LA, Larrazabal C, Ramanathan R et al. Effects of metaproterenol on pulmonary mechanics, oxygenation, and ventilation in infants with chronic lung disease. J Pediatr 1987; 110: 116-119.
69. Gomez-Del Rio M, Gerhardt T, Hehre D et al. Effect of a beta-agonist nebulization on lung function in neonates with increased pulmonary resistance. Pediatr Pulmonol 1986; 2: 287-291.
70. Kao LC, Warburtion D, Platzker AC et al. Effect of isoproterenol inhalation on airway resistance in chronic bronchopulmonary dysplasia. Pediatrics 1984; 73: 509-514.
71. Sosulski R, Abbasi S, Bhutani VK et al. Physiologic effects of terbutaline on pulmonary function of infants with bronchopulmonary dysplasia. Pediatr Pulmonol 1986; 2: 269-273.
72. Sotomayor JL, Godinez RI, Borden S et al. Large-airway collapse due to acquired tracheobronchomalacia in infancy. Am J Dis Child 1986; 140: 367-371.
73. McCubbin M, Frey EE, Wagener JS et al. Large airway collapse in bronchopulmonary dysplasia. J Pediatr 1989; 114: 304-307.
74. Murata K, Itoh H, Todo G. Centrilobar lesions of the lung: demonstration by high resolution CT and pathologic correlation. Radiology 1986; 161: 641-645.
75. Stern RG, Wolfson MR, McGuckin JF et al. High resolution computed tomographic bronchiolography using perfluoroctylbromide (PFOB): an experimental model. J Thorac Imaging 1993; 8: 300-304.
76. Wolfson MR, Stern RG, Kechner N et al. Utility of a perfluorochemical liquid for pulmonary diagnostic imaging. Artif Cells Blood Substit Immobil Biotechnol 1994; 22: 1409-1420.
77. Gross GW, Greenspan JS, Fox WW et al. Use of liquid ventilation with perflubron during extracorporeal membrane oxygenation: chest radiographic appearances. Radiology 1995; 194: 717-720.
78. Miller TF, Greenspan JS, Fox WW et al. Combined ECMO and partial liquid ventilation (PLV) in human neonates: LiquiVent perfluorochemical (PFC) elimination. Pediatr Res 1996; 39: 231A.
79. Fan LL, Flynn JW, Pathak DR et al. Predictive value of stridor in detecting laryngeal injury in extubated neonates. Crit Care Med 1982; 10: 453-455.
80. Sherman JM, Lowitt S, Stephenson C et al. Factors influencing acquired subglottic stenosis in infants. J Pediatr 1986; 109: 322-327.
81. Downing GJ, Kilbride HW. Evaluation of airway complications in high-risk preterm infants: application of flexible fiberoptic airway endoscopy. Pediatrics 1995; 95: 567-572.
82. Sherman JM, Nelson H. Decreased incidence of subglottic stenosis using an "appropriate-sized" endotracheal tube in neonates. Pediatr Pulmonol 1989; 6: 183-185.
83. Miller RW, Woo P, Kellman RK et al. Tracheobronchial abnormalities in infants with bronchopulmonary dysplasia. J Pediatr 1987; 111: 779-782.
84. Greenholz SK, Hall RJ, Lilly JR et al. Surgical implications of bronchopulmonary dysplasia. J Pediatr Surg 1987; 22: 1132-1136.
85. Duncan S, Eid N. Tracheomalacia and bronchopulmonary dysplasia. Ann Otol Rhinol Laryngol 1991; 100: 856-858.
86. Nagaraj HS, Shott R, Fellows R et al. Recurrent lobar atelectasis due to acquired bronchial stenosis in neonates. J Pediatr Surg 1980; 15: 411-415.
87. Grylack LJ, Anderson KD. Diagnosis and treatment of traumatic granuloma in tracheobronchial tree of newborn with history of chronic intubation. J Pediatr Surg 1984; 19: 200-201.
88. Miller KE, Edwards DK, Hilton S et al. Acquired lobar emphysema in premature infants with bronchopulmonary dysplasia: an iatrogenic disease? Radiology 1981; 138: 589-592.
89. Hauft SM, Perlman JM, Siegel MJ et al. Tracheal stenosis in the sick premature infant. Am J Dis Child 1988; 142: 206-209.
90. Moylan FMB, Shannon DC. Preferential distribution of lobar emphysema and atelectasis in bronchopulmonary dysplasia. Pediatrics 1979; 63: 130-134.
91. Mair EA, Parsons DS. Pediatric tracheobronchomalacia and major airway collapse. Ann Otol Rhinol Laryngol 1992; 101: 300-309.
92. Couvreur J, Grimfield A, Tournier G. La dyskinesia tracheale (tracheomalacie) chez l'enfant. Reflexions a propos de 127 cas reconnus par endoscopie. Annales de Pediatrics (Paris) 1980; 27: 561-570.
93. Panitch HB, Talmaciu I, Heckman J et al. Quantitative bronchoscopic assessment of airway collapsibility. Pediatr Res 1998; 43: 832-839.
94. Panitch HB, Talmaciu I, Wolfson MR et al. In vivo quantitation of airway stiffness. Am J Resp Crit Care Med 1998; 157: A470.