Alterations in QT dispersion in medicated schizophrenia patients following electroconvulsive therapy

European Neuropsychopharmacology

Volumn 14, Issue 2, 2004, Pages 121-125

  Nahshoni, Eitan ^a,d   Manor, Nira ^b,d   Bar, Faina ^b,d   Stryjer, Rafael ^b,d   Zalsman, Gil ^a,d   Weizman, Abaraham ^a,c,d  

^a GEHA MENTAL HEALTH CENTER   (Israel)

^b BEER YAAKOV MENTAL HEALTH CENTER   (Israel)

^c RABIN MEDICAL CENTER   (Israel)

^d TEL AVIV UNIVERSITY   (Israel)

Author keywords

ECG; Electroconvulsive therapy; Heart; QT dispersion; QT interval; Schizophrenia

Indexed keywords

AMANTADINE; BIPERIDEN; FLUPHENAZINE; FLUPHENAZINE DECANOATE; HALOPERIDOL; LEVOMEPROMAZINE; NEUROLEPTIC AGENT; OLANZAPINE; PERPHENAZINE; PROCYCLIDINE; PROMETHAZINE; RISPERIDONE; ZUCLOPENTHIXOL;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTROCONVULSIVE THERAPY; FEMALE; HUMAN; MAINTENANCE THERAPY; MALE; PRIORITY JOURNAL; QT DISPERSION; QT INTERVAL; RATING SCALE; SCHIZOPHRENIA; TREATMENT OUTCOME;

EID: 0842328610     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-977X(03)00098-1     Document Type: Article

References (32)

1. Agelink M.W., Malessa R., Kamcili E., Zeit T., Lemmer W., Bertling R., Klieser E. Cardiovascular autonomic reactivity in schizophrenics under neuroleptic treatment: a potential predictor of short-term outcome? Neuropsychobiology. 38:1998;19-24.
2. Barr C.S., Naas A., Freeman M., Struthers A.D. QT dispersion and sudden unexpected death in chronic heart failure. Lancet. 343:1994;327-329.
3. Bazett H.C. An analysis of the time relations of electrocardiograms. Heart. 7:1920;353-370.
4. Davidowski T.A., Wolf S. The QT interval during reflex cardiovascular adaptation. Circulation. 69:1984;22-25.
5. Dawson M.E., Nuechterlein K.H., Schell A.M., Gitlin M., Ventura J. Autonomic abnormalities in schizophrenia: state or trait indicators? Arch. Gen. Psychiatry. 51:1994;813-824.
6. Day C.P., McComb J.M., Campbell R.W.F. QT dispersion: an indication of arrhythmia risk in patients with long QT intervals. Br. Heart J. 63:1990;342-344.
7. First M.B., Spitzer R.L., Gibbon M., Williams J.B.W. Structured Clinical Interview for Axis DSM-IV Disorders. Patient Edition:1996;Biometrics Research Department, NY State Psychiatric Institute, New York. (SCID-I/P 2.0).
8. Fuenmayor A.J., el Fakih Y., Moreno J., Fuenmayor A.M. Effects of electroconvulsive therapy on cardiac function in patients without heart disease. Cardiology. 88:1997;254-257.
9. Gaines G.Y. 3rd, Rees D.I. Anesthetic considerations for electroconvulsive therapy. South. Med. J. 85:1992;469-482.
10. Glassman A.H., Bigger J.T. Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death. Am. J. Psychiatry. 158:2001;1774-1782.
11. Guler N., Bilge M., Eryonucu B., Kutanis R., Erkoc R. The effect of electroconvulsive therapy on QT dispersion. Acta Cardiol. 53:1998;355-358.
12. Hartigan-Go K., Batemen N., Nyberg G., Martensson E., Thomas S.H.L. Concentration-related pharmacodynamic effect of thioridazine and its metabolites in humans. Clin. Pharmacol. Ther. 60:1996;543-553.
13. Higham P.D., Campbell R.W. QT dispersion. Br. Heart J. 71:1994;508-510.
14. Ishida S., Nakagawa M., Fujino T., Yonemochi H., Saikawa T., Ito M. Circadian variation of QT interval dispersion: correlation with heart rate variability. J. Electrocardiol. 30:1997;205-210.
15. Kitayama H., Kiuchi K., Nejima J., Katoh T., Takano T., Hayakawa H. Long-term treatment with antipsychotic drugs in conventional doses prolonged QTc dispersion, but did not increase ventricular tachyarrhythmias in patients with schizophrenia in the absence of cardiac disease. Eur. J. Clin. Pharmacol. 55:1999;259-262.
16. Malaspina D., Bruder G., Dalack G.W., Storer S., Van Kammen M., Amador X., Glassman A., Gorman J. Diminished cardiac vagal tone in schizophrenia: associations to brain laterality and age of onset. Biol. Psychiatry. 41:1997;612-617.
17. Manttari M., Oikarinen L., Manninen V., Viitasalo M. QT dispersion as a risk factor for sudden cardiac death and fatal myocardial infarction in a coronary risk population. Heart. 78:1997;268-272.
18. Nahshoni E., Aizenberg D., Sigler M., Zalsman G., Strasberg B., Imbar S., Weizman A. Heart rate variability in elderly patients before and after electroconvulsive therapy. Am. J. Geriatr. Psychiatry. 9:2001;255-260.
19. Nahshoni, E., Gur, S., Marom, Z., Levine-Pore, J., Weizman, A., Hermesh, H., 2003. QT dispersion in patients with social phobia. J. Affect. Disord. (in press).
20. Nakagawa M., Takahashi N., Iwao T., Yonemochi H., Ooie T., Hara M., Saikawa T., Ito M. Evaluation of autonomic influence on QT dispersion using head-up tilt test in healthy subjects. Pacing Clin. Electrophysiol. 22:1999;1158-1163.
21. Nielsen B.M., Mehlsen J., Behnke K. Altered balance in the autonomic nervous system in schizophrenic patients. Clin. Physiol. 8:1988;193-199.
22. Ray W.A., Meredith S., Thapa P.B., Meador K.G., Hall K., Murray K.T. Antipsychotics and the risk of sudden cardiac death. Arch. Gen. Psychiatry. 58:2001;1161-1167.
23. Roukema G., Singh J.P., Meijs M., Carvalho C., Hart G. Effects of exercise-induced ischemia on QT interval dispersion. Am. Heart J. 135:1998;88-92.
24. Rumi D.O., Solimene M.C., Takada J.Y., Grupi C.J., Giorgi D.M., Rigonatti S.P., Luz P.L., Ramires J.A. Electrocardiographic and blood pressure alterations during electroconvulsive therapy in young adults. Arq. Bras. Cardiol. 79:2002;155-160.
25. Sackeim H., Decina P., Prohovnik I., Malitz S. Seizure threshold in electroconvulsive therapy: effect of sex, age, electrode placement, and the number of treatments. Arch. Gen. Psychiatry. 44:1987;355-360.
26. Schweitzer P. The values and limitations of the QT interval in clinical practice. Am. Heart J. 124:1992;1121-1124.
27. Statters D.J., Malik M., Ward D.E., Camm A.J. QT dispersion: problems of methodology and clinical significance. J. Cardiovasc. Electrophysiol. 5:1994;672-685.
28. Toichi M., Kubota Y., Murai T., Kamio Y., Sakihama M., Toriuchi T., Inakuma T., Sengoku A., Miyoshi K. The influence of psychotic states on the autonomic nervous system in schizophrenia. Int. J. Psychophysiol. 31:1999;147-154.
29. van de Loo A., Arendts W., Hohloser S.H. Variability of QT dispersion measurements in the surface electrocardiogram in patients with acute myocardial infarction and in normal subjects. Am. J. Cardiol. 74:1994;1113-1118.
30. Warner J.P., Barnes T.R.E., Henry J.A. Electrocardiographic changes in patients receiving neuroleptic medication. Acta Psychiatr. Scand. 93:1996;311-313.
31. Zahn T.P., Carpenter W.T. Jr., McGlashan T.H. Autonomic nervous system activity in acute schizophrenia: I. Method and comparison with normal controls. Arch. Gen. Psychiatry. 38:1981;251-258.
32. Zarate C.A., Patel J. Sudden cardiac death and antipsychotic drugs. Arch. Gen. Psychiatry. 58:2001;1168-1171.