HER2/neu and Ki-67 as Prognostic Indicators in Mucoepidermoid Carcinoma of Salivary Glands

Journal of Otolaryngology

Volumn 32, Issue 5, 2003, Pages 328-331

  Nguyen, Lily H P ^a   Black, Martin J ^a,b   Hier, Michael ^a   Chauvin, Peter ^a   Rochon, Louise ^a  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

HER2 neu; Immunohistochemistry; Ki 67; Mucoepidermoid carcinoma; Salivary glands

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; KI 67 ANTIGEN; ONCOPROTEIN; TUMOR MARKER;

ADENOSQUAMOUS CARCINOMA; ADULT; ARTICLE; CANCER GRADING; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; OUTCOMES RESEARCH; PRIORITY JOURNAL; PROGNOSIS; RETROSPECTIVE STUDY; SALIVARY GLAND CARCINOMA; STAINING;

EID: 0842327456     PISSN: 03816605     EISSN: None     Source Type: Journal    
DOI: 10.2310/7070.2003.11438     Document Type: Article

References (19)

1. Spiro RH. Salivary neoplasms: overview of a 35-year experience with 2, 807 patients. Head Neck Surg 1986; 8:177-184.
2. Stewart FW, Foote FW, Becker WF. Mucoepidermoid tumors of salivary glands. Ann Surg 1945; 122:820-844.
3. Masson P, Berger L. Epitheliome a double metaplasie de la parotide. Bull Cancer 1924; 13:366.
4. Schilling F. Beitrag zur Kenntnis der Parotidgeschwulstele. Beitr Pathol Anat 1921; 68:139-160.
5. Thackray AC, Sobin LH. Histological typing of salivary gland tumors. In: World Health Organization international histological classification of tumours, 1st ed. Geneva: WHO, 1972.
6. Seifert G, Sobin LH. Histological classification of salivary gland tumours. In: World Health Organization international histological classification of tumours. Berlin: Springer-Verlag, 1991.
7. Batsakis JG, Luna MA. Histopathologic grading of salivary gland neoplasms: I. Mucoepidermoid carcinomas. Ann Otol Rhinol Laryngol 1990; 99(10 Pt 1):835-838.
8. Foote FW Jr, Fazell EL. Tumors of major salivary glands. Cancer 1953; 6:1065-1133.
9. Auclair PL, Goode RK, Ellis GL. Mucoepidermoid carcinoma of intraoral salivary glands: evaluation and application of grading criteria in 143 cases. Cancer 1992; 69:2021-2030.
10. Ussmuller J, Donath K, Hartwein J. Site and epidemiology of mucoepidermoid carcinoma-analysis of 327 cases. Laryngorhinootologie 1994; 73:478-481.
11. Hicks MJ, El-Naggar AK, Byers RM, et al. Prognostic factors in mucoepidermoid carcinoma of major salivary glands: a clinicopathologic and flow cytometric study. Eur J Cancer B Oral Oncol 1994; 30B:329-334.
12. Batsakis JG. Staging of salivary gland neoplasms: role of histopathologic and molecular factors. Am J Surg 1994; 168:386-390.
13. Allred CD, Harvey JM, Berardo M, et al. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod Pathol 1998; 11:155-168.
14. Press MF, Pike MC, Hung G, et al. Amplification and overexpression of HER-2/neu in carcinomas of the salivary gland: correlation with poor prognosis. Cancer Res 1994; 54:5675-5682.
15. Kernohan NM, Blessing K, King G, et al. Expression of c-erbB-2 oncoprotein in salivary gland tumors: an immunohistochemical study. J Pathol 1991; 163:77-80.
16. Sugano S, Mukai K, Tsuda H, et al. Immunohistochemical study of c-erb oncoprotein overexpression in human major salivary gland carcinoma: an indicator of aggressiveness. Laryngoscope 1992; 102:923-927.
17. Gerdes J. Ki-67 and other proliferation markers useful for immunohistological diagnostic and prognostic evaluations in human malignancies. Semin Cancer Biol 1990; 1:199-206.
18. Giannoni C, el-Naggar AK, Ordonez NG, et al. c-erbB-2/neu oncogene and Ki-67 analysis in the assessment of palatal salivary gland neoplasms. Otolaryngol Head Neck Surg 1995; 112:391-398.
19. Skalova A, Lehtonen H, von Boguslawsky K, et al. Prognostic significance of cell proliferation in mucoepidermoid carcinoma of the salivary gland: clinicopathological study using MIB 1 antibody in paraffin sections. Hum Pathol 1994; 25:929-935.