Mice lacking the UbCKmit isoform creatine kinase reveal slower spatial learning acquisition, diminished exploration and habituation, and reduced acoustic startle reflex responses

Molecular and Cellular Biochemistry

Volumn 256-257, Issue 1-2, 2004, Pages 305-318

  Streijger, Femke ^a   Jost, Carolina R ^a,c   Oerlemans, Frank ^a   Ellenbroek, Bart A ^b   Cools, Alexander R ^b   Wieringa, Bé ^a   Van der Zee, Catharina E E ^a  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Behavioral phenotyping; Brain energy metabolism; Creatine kinase deficient mice; Ubiquitous mitochondrial creatine kinase

Indexed keywords

CREATINE KINASE BB; ISOENZYME;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUDITORY SYSTEM; AUDITORY THRESHOLD; BRAIN CELL; BRAIN CORTEX; BRAIN METABOLISM; BRAIN MITOCHONDRION; BRAIN STEM; CELL NUCLEUS; CEREBELLUM; CONTROLLED STUDY; CYTOSOL; ENERGY METABOLISM; ENERGY TRANSFER; ENZYME DEFICIENCY; EXPLORATORY BEHAVIOR; FEMALE; HABITUATION; HIPPOCAMPUS; LEARNING; MALE; MAZE TEST; MESENCEPHALON; MOUSE; NERVE CELL NETWORK; NONHUMAN; OPEN FIELD TEST; PREPULSE INHIBITION; RHOMBENCEPHALON; SENSORIMOTOR FUNCTION; SIGNAL TRANSDUCTION; STARTLE REFLEX; SYNAPTIC TRANSMISSION; TASK PERFORMANCE;

ANIMALIA;

EID: 0842323745     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/b:mcbi.0000009877.90129.e3     Document Type: Article

References (38)

1. Wallimann T, Wyss M, Brdiczka D, Nicolay K, Eppenberger HM: Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: The 'phosphocreatine circuit' for cellular energy homeostasis. Biochem J 281: 21-40, 1992
2. Jost CR, Van der Zee CEEM, In 't Zandt HJA, Oerlemans F, Verheij M, Streijger F, Fransen J, Heerschap A, Cools AR, Wieringa B: Creatine kinase B-driven energy transfer in the brain is important for habituation and spatial learning behaviour, mossy fiber field size and determination of seizure susceptibility. Eur J Neurosci 15: 1692-1706, 2002
3. Wyss M, Kaddurah-Daouk R: Creatine and creatine metabolism. Physiol Rev 80: 1107-1213, 2000
4. Barinaga M: What makes brain neurons run? Science 276: 196-198, 1997
5. Tsacopoulos M, Magistretti PJ: Metabolic coupling between glia and neurons. J Neurosci 16: 877-885, 1996
6. Deitmer JW: Glial strategy for metabolic shuttling and neuronal function. BioEssays 22: 747-752, 2000
7. Chih C-P, Lipton P, Roberts EL Jr: Do active cerebral neurons really use lactate rather than glucose? Trends Neurosci 24: 573-578, 2001
8. Dienel DA, Hertz L: Glucose and lactate metabolism during brain activation. J Neurosci Res 66: 824-838, 2001
9. Sauter A, Rudin M: Determination of creatine kinase kinetic parameters in rat brain by NMR magnetization transfer. Correlation with brain function. J Biol Chem 268: 13166-13171, 1993
10. Bessman SP, Carpenter CL: The creatine-creatine phosphate energy shuttle. Annu Rev Biochem 54: 831-862, 1985
11. O'Gorman E, Beutner G, Wallimann T, Brdiczka D: Differential effects of creatine depletion on the regulation of enzyme activities and on creatine-stimulated mitochondrial respiration in skeletal muscle, heart, and brain. Biochim Biophys Acta 1276: 161-170, 1996
12. Schlattner U: Adenylate kinase isoforms in higher plants. Recent Res Devel in Phytochem 1: 439-465, 1997
13. Tsuji M, Allred E, Jensen F, Holtzman D: Phosphocreatine and ATP regulation in the hypoxic developing rat brain. Brain Res Dev Brain Res 85: 192-200, 1995
14. Holtzman D, Togliatti A, Khait I, Jensen F: Creatine increases survival and suppresses seizures in the hypoxic immature rat. Pediatr Res 44: 410-414, 1998
15. Matthews RT, Yang L, Jenkins BG, Ferrante RJ, Rosen BR, Kaddurah-Daouk R, Beal MF: Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease. J Neurosci 18: 156-163, 1998
16. Matthews RT, Ferrante RJ, Klivenyi P, Yang L, Klein AM, Mueller G, Kaddurah-Daouk R, Beal MF: Creatine and cyclocreatine attenuate MPTP neurotoxicity. Exp Neurol 157: 142-149, 1999
17. Klivenyi P, Ferrante RJ, Matthews RT, Bogdanov MB, Klein AM, Andreassen OA, Mueller G, Wermer M, Kaddurah-Daouk R, Beal MF: Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis. Nat Med 5: 347-350, 1999
18. Ferrante RJ, Andreassen OA, Jenkins BG, Dedeoglu A, Kuemmerle S, Kubilus JK, Kaddurah-Daouk R, Hersch SM, Beal MF: Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease. J Neurosci 20: 4389-4397, 2000
19. Stockler S, Isbrandt D, Hanefeld F, Schmidt B, von Figura K: Guanidinoacetate methyltransferase deficiency: the first inborn error of creatine metabolism in man. Am J Hum Genet 58: 914-922, 1996
20. Van Deursen J, Heerschap A, Oerlemans F, Ruitenbeek W, Jap PH, Ter Laak H, Wieringa B: Skeletal muscle of mice deficient in muscle creatine kinase lack burst activity. Cell 74: 621-631, 1993
21. 2+ responses in muscles with combined mitochondrial and cytosolic creatine kinase deficiencies. Cell 89: 93-103, 1997
22. In 't Zandt HJA, Klomp DWJ, Oerlemans F, Wieringa B, Hilbers CW, Heerschap A: Proton MR spectroscopy of wildtype and creatine deficient mouse skeletal muscle: Dipole-dipole coupling effects and postmortem changes. Magn Res Med 43: 517-524, 2000
23. De Groof AJC, Oerlemans F, Jost CR, Wieringa, B: Changes in glycolytic network and mitochondrial design in creatine kinase deficient muscle. Muscle Nerve 24: 1188-1196, 2001
24. De Groof AJC: Cellular remodeling in creatine kinase-deficient muscles: Adaptive changes and regulatory mechanisms. ISBN 90-9015729-8 Thesis book, University of Nijmegen, The Netherlands, 2002
25. Steeghs K, Oerlemans F, Wieringa B: Mice deficient in ubiquitous mitochondrial creatine kinase are viable and fertile. Biochim Biophys Acta 1230: 130-138, 1995
26. Friedman DL, Perryman MB: Compartmentation of multiple forms of creatine kinase in the distal nephron of the rat kidney. J Biol Chem 266: 22404-22410, 1991
27. McIlwain KL, Merriweather MY, Yuva-Paylor LA, Paylor R: The use of behavioral test batteries: Effects of training history. Physiol Behav 73: 705-717, 2001
28. Sakic B, Szechtman H, Talangbayan H, Denburg SD, Carbotte RM, Denburg JA: Disturbed emotionality in autoimmune MRL-lpr mice. Physiol Behav 56: 609-617, 1994
29. Tchernichovski O, Golani I: A phase plane representation of rat exploratory behavior. J Neurosci Meth 62: 21-27, 1995
30. 31P MR-spectroscopy and -imaging reveal changes in metabolite levels and morphology of creatine kinase (CK)-deficient mouse brain. ISBN 90-64642054: Thesis book, Chapter 7, University of Nijmegen, The Netherlands, 2000
31. Crusio WE, van Abeelen JH: Zinc-induced peripheral anosmia and behavioral responses to novelty in mice: A quantitative-genetic analysis. Behav Neural Biol 48: 63-82, 1987
32. Gerlai RT: Genotype x environment interaction: An old problem in a new field. Trends Neurosci 23: 450, 2000
33. Swerdlow NR, Geyer MA, Braff DL: Neural circuit regulation of prepulse inhibition of startle in the rat: Current knowledge and future challenges. Psychopharmacol 156: 194-215, 2001
34. Ellenbroek BA, Budde S, Cools AR: Prepulse inhibition and latent inhibition: The role of dopamine in the medial prefrontal cortex. Neuroscience 75: 535-542, 1996
35. Paylor R, Crawley JN: Inbred strain differences in prepulse inhibition of the mouse startle response. Psychopharmacol 132: 169-180, 1997
36. Koch M, Kungel M, Herbert H: Cholinergic neurons in the pedunculo-pontine tegmental nucleus are involved in the mediation of prepulse inhibition of the acoustic startle response in the rat. Exp Brain Res 97: 71-82, 1993
37. Shulman RG, Hyder F, Rothman DL: Cerebral energetics and the glycogen shunt: Neurochemical basis of functional imaging. Proc Natl Acad Sci USA 98: 6417-6422, 2001
38. Fields RD, Stevens-Graham B: New insights into neuron-glia communication. Science 298: 556-562, 2002