Effect of High-Frequency Stimulation of the Subthalamic Nucleus on Subthalamic Neurons: An Intracellular Study

Stereotactic and Functional Neurosurgery

Volumn 80, Issue 1-4, 2003, Pages 32-36

  Lee, Kendall H ^a   David, W Roberts ^a   Kimb, Uhnoh ^b  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b IOWA STATE UNIVERSITY   (United States)

Author keywords

Deep brain stimulation; Electrophysiology; High frequency stimulation; Subthalamic nucleus

Indexed keywords

ANIMAL MODEL; ANIMAL TISSUE; BRAIN DEPTH STIMULATION; BRAIN ELECTROPHYSIOLOGY; BRAIN NERVE CELL; BRAIN SLICE; CONFERENCE PAPER; CONTROLLED STUDY; ELECTRODE; ELECTROSTIMULATION; EXCITATORY POSTSYNAPTIC POTENTIAL; FEMALE; FREQUENCY MODULATION; IN VITRO STUDY; MALE; NERVE POTENTIAL; NONHUMAN; POSTSYNAPTIC INHIBITION; RAT; SUBTHALAMIC NUCLEUS;

ACTION POTENTIALS; ANIMALS; ELECTRIC STIMULATION THERAPY; EXCITATORY POSTSYNAPTIC POTENTIALS; FEMALE; MALE; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; SUBTHALAMIC NUCLEUS;

EID: 0842320979     PISSN: 10116125     EISSN: None     Source Type: Journal    
DOI: 10.1159/000075157     Document Type: Conference Paper

References (3)

1. Deep-Brain Stimulation for Parkinson's Disease Study Group: Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson's disease. N Engl J Med 2001;345:956-963.
2. Beurrier C, Bioulac B, Audin J, Hammond C: High-frequency stimulation produces a transient blockade of voltage-gated currents in subthalamic neurons. J Neurophysiol 2001;85:1351-1356.
3. Magarinos-Ascone C, Pazo JH, Macadar O, Buno W: High-frequency stimulation of the subthalamic nucleus silences subthalamic neurons: A possible cellular mechanism in Parkinson's disease. Neuroscience 2002;115:1109-1117.